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Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke.

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Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke.

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dc.contributor.author Sanchez-Rojas, Leyre es_ES
dc.contributor.author Gómez-Pinedo, Ulises es_ES
dc.contributor.author Benito-Martin, María Soledad es_ES
dc.contributor.author León-Espinosa, Gonzalo es_ES
dc.contributor.author Rascón-Ramirez, Fernando es_ES
dc.contributor.author Lendinez, Cristina es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.contributor.author Matías-Guiu, Jorge es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Barcia, Juan A. es_ES
dc.date.accessioned 2021-01-09T04:31:58Z
dc.date.available 2021-01-09T04:31:58Z
dc.date.issued 2019-07 es_ES
dc.identifier.issn 1552-4973 es_ES
dc.identifier.uri http://hdl.handle.net/10251/158499
dc.description.abstract [EN] Endogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) biomaterials (BM) could provide a suitable environment to home not only new neurons, but also vessels, glia and neurofilaments. Further, the addition of exogenous cells, such as adipose stem cells (ASC) could increase this effect. Athymic mice were randomly assigned to a one of four group: stroke alone, stroke and implantation of BM, stroke and implantation of BM with ASC, and sham operated animals. Stroke model consisted of middle cerebral artery thrombosis with FeCl3. After 30 days, animals underwent magnetic resonance imaging (MRI) and were sacrificed. Proliferation and neurogenesis increased at the subventricular zone ipsilateral to the ventricle and neuroblasts, glial, and endothelial cells forming capillaries were seen inside the BM. Those effects increased when ASC were added, while there was less inflammatory reaction. Three-dimensional scaffolds made of HA are able to home newly formed neurons, glia, and endothelial cells permitting the growth neurofilaments inside them. The addition of ASC increase these effects and decrease the inflammatory reaction to the implant. es_ES
dc.description.sponsorship Contract grant sponsor: CIBER BBN Contract grant sponsor: ERANET NEURON CALL; contract grant number: PRI-PIMNEU-2011-1372 Contract grant sponsor: Spanish Science & Innovation Ministery; contract grant number: MAT 2011-28791-C03-01, MAT 2011-28791-C03-02 an Contract grant sponsor: TERCEL; contract grant number: RD12/0019/0010 Contract grant sponsor: Spanish Ministry of Economy and Competitiveness through grants MAT2015-66666-C3, and DPI2015-72863-EXP es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation MINISTERIO DE ECONOMIA Y EMPRESA/MAT2011-28791-C03-02 es_ES
dc.relation.ispartof Journal of Biomedical Materials Research Part B Applied Biomaterials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biomaterials es_ES
dc.subject Hyaluronic acid es_ES
dc.subject Cell therapy es_ES
dc.subject Adipose stem cells es_ES
dc.subject Stroke es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbm.b.34252 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-66666-C3-2-R/ES/BIOHIBRIDOS PARA LA PROMOCION DEL CRECIMIENTO AXONAL Y LA REGENERACION EN LESION MEDULAR AGUDA Y CRONICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0019%2F0010/ES/Terapia Celular/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-01/ES/BIOHIBRIDOS DE CELULAS TRONCALES Y MATERIALES PARA AUMENTAR LA SUPERVIVENCIA, INTEGRACION Y REGENERACION AXONAL EN EL SISTEMA NERVIOSO CENTRAL.MODELOS ANIMALES DE EP, ELA E IC/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PRI-PIMNEU-2011-1372/ES/MATERIALES BIFUNCIONALES PARA LA REGENERACION NEURAL DE AREAS AFECTADAS POR ICTUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//DPI2015-72863-EXP/ES/NEUROCABLES MODULARES: MULTIPLICANDO CONEXIONES NEURALES/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Sanchez-Rojas, L.; Gómez-Pinedo, U.; Benito-Martin, MS.; León-Espinosa, G.; Rascón-Ramirez, F.; Lendinez, C.; Martínez-Ramos, C.... (2019). Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke. Journal of Biomedical Materials Research Part B Applied Biomaterials. 107(5):1598-1606. https://doi.org/10.1002/jbm.b.34252 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/jbm.b.34252 es_ES
dc.description.upvformatpinicio 1598 es_ES
dc.description.upvformatpfin 1606 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 107 es_ES
dc.description.issue 5 es_ES
dc.identifier.pmid 30307108 es_ES
dc.relation.pasarela S\399794 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
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