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Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Application

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Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Application

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dc.contributor.author Uscategui, Yomaira L. es_ES
dc.contributor.author Diaz, Luis E. es_ES
dc.contributor.author Gómez-Tejedor, José-Antonio es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Vilariño, Guillermo es_ES
dc.contributor.author Serrano, María-Antonia es_ES
dc.contributor.author Valero, Manuel F. es_ES
dc.date.accessioned 2021-01-12T04:31:40Z
dc.date.available 2021-01-12T04:31:40Z
dc.date.issued 2019-01-10 es_ES
dc.identifier.issn 1420-3049 es_ES
dc.identifier.uri http://hdl.handle.net/10251/158675
dc.description.abstract [EN] Polyurethanes are widely used in the development of medical devices due to their biocompatibility, degradability, non-toxicity and chemical versatility. Polyurethanes were obtained from polyols derived from castor oil, and isophorone diisocyanate, with the incorporation of polycaprolactone-diol (15% w/w) and chitosan (3% w/w). The objective of this research was to evaluate the effect of the type of polyol and the incorporation of polycaprolactone-diol and chitosan on the mechanical and biological properties of the polyurethanes to identify the optimal ones for applications such as wound dressings or tissue engineering. Polyurethanes were characterized by stress-strain, contact angle by sessile drop method, thermogravimetric analysis, differential scanning calorimetry, water uptake and in vitro degradation by enzymatic processes. In vitro biological properties were evaluated by a 24 h cytotoxicity test using the colorimetric assay MTT and the LIVE/DEAD kit with cell line L-929 (mouse embryonic fibroblasts). In vitro evaluation of the possible inflammatory effect of polyurethane-based materials was evaluated by means of the expression of anti-inflammatory and proinflammatory cytokines expressed in a cellular model such as THP-1 cells by means of the MILLIPLEX® MAP kit. The modification of polyols derived from castor oil increases the mechanical properties of interest for a wide range of applications. The polyurethanes evaluated did not generate a cytotoxic effect on the evaluated cell line. The assessed polyurethanes are suggested as possible candidate biomaterials for wound dressings due to their improved mechanical properties and biocompatibility. es_ES
dc.description.sponsorship This research was funded by the UNIVERSIDAD DE LA SABANA, grant number ING-202-2018 and by COLCIENCIAS under scholarship grant 617-2-2014. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. J.A.G.-T. and A.V.-LL. acknowledge the support of the Spanish Ministry of Economy and Competitiveness (MINECO) through project DPI2015-65401-C3-2-R (including FEDER financial support). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Molecules es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Castor oil es_ES
dc.subject Biomedical devices es_ES
dc.subject Polyurethanes es_ES
dc.subject Polycaprolactone-diol es_ES
dc.subject Chitosan es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Application es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/molecules24020237 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Universidad de La Sabana//ING-202-2018/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/COLCIENCIAS//617-2-2014/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//DPI2015-65401-C3-2-R/ES/SOPORTES POLIMERICOS MULTIFUNCIONALES PARA CO-CULTIVO CELULAR INDIRECTO Y ESTIMULACION QUIMICA DESTINADOS A MIMETIZAR TEJIDO RENAL IN VITRO/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Uscategui, YL.; Diaz, LE.; Gómez-Tejedor, J.; Vallés Lluch, A.; Vilariño, G.; Serrano, M.; Valero, MF. (2019). Candidate Polyurethanes Based on Castor Oil (Ricinus communis), with Polycaprolactone Diol and Chitosan Additions, for Use in Biomedical Application. Molecules. 24(2):1-30. https://doi.org/10.3390/molecules24020237 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/molecules24020237 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 30 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 30634633 es_ES
dc.identifier.pmcid PMC6359294 es_ES
dc.relation.pasarela S\375368 es_ES
dc.contributor.funder Universidad de La Sabana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Departamento Administrativo de Ciencia, Tecnología e Innovación, Colombia es_ES
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