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Health-related quality of life in patients with systemic lupus erythematosus: a Spanish study based on patient reports

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Health-related quality of life in patients with systemic lupus erythematosus: a Spanish study based on patient reports

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Nombre: Román;Fernández-L ...
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dc.contributor.author Román Ivorra, J. A. es_ES
dc.contributor.author Fernández-Llanio-Comella, N. es_ES
dc.contributor.author San-Martín-Álvarez, A. es_ES
dc.contributor.author Vela-Casasempere, P. es_ES
dc.contributor.author Saurí-Ferrer, I. es_ES
dc.contributor.author González-De Julián, Silvia es_ES
dc.contributor.author Vivas-Consuelo, David es_ES
dc.date.accessioned 2021-01-14T04:32:29Z
dc.date.available 2021-01-14T04:32:29Z
dc.date.issued 2019-07 es_ES
dc.identifier.issn 0770-3198 es_ES
dc.identifier.uri http://hdl.handle.net/10251/158940
dc.description.abstract [EN] Introduction and objectivesSystemic lupus erythematosus (SLE) is a disease that significantly affects the quality of life and welfare of patients. SLE patients can be classified into multimorbidity levels using Clinical Risk Groups (CRGs) to help to incorporate predictive models of health needs. The goal of this study was to correlate CRGs with health-related quality of life (HR-QoL) and costs in SLE patients.MethodsA questionnaire was administered to SLE patients in four hospital centers of the Valencian Community (Spain) between October 2015 and March 2016. The factors studied included HR-QoL (EQ-5D-5L and VAS), disease activity (SLAI/SELENA), damage (SLICC/ACR), and severity (IGK).ResultsThe patients (N=190, 92.06% female, age (mean SD) 47.23 +/- 13.43years) were sorted according to health status in nine CRGs. We found that most SLE patients (>70%) were in CRGs 5 and 6. The main HR-QoL issues in these patients were related to mobility, ability to perform usual activities, and pain/discomfort. The scores (mean +/- SD) for EQ-5D-5L and VAS were 0.74 +/- 0.25 and 65.67 +/- 23.52, respectively. We found that the age of the patients negatively affected their HR-QoL (r=-0.266). SLE direct costs per patient increased with each CRG group, representing 71.92% of the total costs, while indirect costs were highly variable. The average cost per patient with SLE amounted to Euro8432.85 (year 2014).Conclusions Patients' quality of life is related with age, disease activity, damage, and severity. Age was the parameter which most affects HR-QoL. Most costs of SLE are concentrated in two CRGs in which the HR-QoL deteriorates sharply. es_ES
dc.description.sponsorship The authors thank Francisco López de Saro (Trialance SCCL) for medical writing support. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Clinical Rheumatology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Health-related quality of life es_ES
dc.subject Patient costs es_ES
dc.subject Patient-reported outcomes es_ES
dc.subject Systemic lupus erythematosus es_ES
dc.subject.classification ECONOMIA APLICADA es_ES
dc.subject.classification ECONOMIA FINANCIERA Y CONTABILIDAD es_ES
dc.title Health-related quality of life in patients with systemic lupus erythematosus: a Spanish study based on patient reports es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10067-019-04485-6 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Economía y Ciencias Sociales - Departament d'Economia i Ciències Socials es_ES
dc.description.bibliographicCitation Román Ivorra, JA.; Fernández-Llanio-Comella, N.; San-Martín-Álvarez, A.; Vela-Casasempere, P.; Saurí-Ferrer, I.; González-De Julián, S.; Vivas-Consuelo, D. (2019). Health-related quality of life in patients with systemic lupus erythematosus: a Spanish study based on patient reports. Clinical Rheumatology. 38(7):1857-1864. https://doi.org/10.1007/s10067-019-04485-6 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s10067-019-04485-6 es_ES
dc.description.upvformatpinicio 1857 es_ES
dc.description.upvformatpfin 1864 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 38 es_ES
dc.description.issue 7 es_ES
dc.identifier.pmid 30820696 es_ES
dc.relation.pasarela S\379783 es_ES
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