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Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate

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Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate

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dc.contributor.author Añón, Elena es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author Amorós del Toro, Pedro es_ES
dc.contributor.author El Haskouri, Jamal es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Parra Álvarez, Margarita es_ES
dc.contributor.author Gil Grau, Salvador es_ES
dc.contributor.author Gaviña, Pablo es_ES
dc.contributor.author Terencio Silvestre, María Carmen es_ES
dc.contributor.author Alfonso-Navarro, María es_ES
dc.date.accessioned 2021-01-14T04:32:55Z
dc.date.available 2021-01-14T04:32:55Z
dc.date.issued 2020-03-31 es_ES
dc.identifier.uri http://hdl.handle.net/10251/158947
dc.description This is the peer reviewed version of the following article: E. Añón, A. M. Costero, P. Amorós, J. El Haskouri, R. Martínez-Mánez, M. Parra, S. Gil, P. Gaviña, M. C. Terencio, M. Alfonso, ChemistrySelect 2020, 5, 3618., which has been published in final form at https://doi.org/10.1002/slct.202000417. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.description.abstract [EN] Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. Here we present the synthesis and characterization of mesoporous gated nanoparticles (two sets) for the controlled release of alendronate. The first set of nanoparticles (S1) were loaded with sulforhodamine B and capped with a peptide that could be selectively hydrolyzed by cathepsin K enzyme (overexpressed in osteoclasts). The second set (S2) was functionalized with aminopropyl moieties, loaded with nitrobenzofurazan labelled alendronate and capped with the same peptide. Both nanoparticles were internalized by RAW 264.7 macrophages (which could differentiate in osteoclasts) and were able to release its entrapped cargo in the presence of cathepsin K added in the macrophage lysates. Using S2 nanoparticles 4.2% of the total alendronate amount in contact with the cells is liberated inside them and could produce its therapeutic effect. es_ES
dc.description.sponsorship We thank the Spanish Government (RTI2018-100910-B-C41, RTI2018-100910-B-C42 (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (PROMETEU/2018/024) for support. SCSIE (Universitat de Valencia) is gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS "NANBIOSIS" at the Universitat of Valencia. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation MICINN/RTI2018-100910-B-C42 es_ES
dc.relation GENERALITAT VALENCIANA/PROMETEO/2018/024 es_ES
dc.relation info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.relation.ispartof ChemistrySelect es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Alendronate es_ES
dc.subject Enzymes es_ES
dc.subject Cathepsin K es_ES
dc.subject Nanoparticles es_ES
dc.subject Osteoporosis es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/slct.202000417 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Añón, E.; Costero, AM.; Amorós Del Toro, P.; El Haskouri, J.; Martínez-Máñez, R.; Parra Álvarez, M.; Gil Grau, S.... (2020). Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate. ChemistrySelect. 5(12):3618-3625. https://doi.org/10.1002/slct.202000417 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/slct.202000417 es_ES
dc.description.upvformatpinicio 3618 es_ES
dc.description.upvformatpfin 3625 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 12 es_ES
dc.identifier.eissn 2365-6549 es_ES
dc.relation.pasarela S\418264 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES


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