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Citrus exocortis viroid causes ribosomal stress in tomato plants

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Citrus exocortis viroid causes ribosomal stress in tomato plants

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dc.contributor.author Cottilli, Patrick es_ES
dc.contributor.author Belda-Palazón, Borja es_ES
dc.contributor.author Adkar-Purushothama, Charith Raj es_ES
dc.contributor.author Perreault, Jean-Pierre es_ES
dc.contributor.author Schleiff, Enrico es_ES
dc.contributor.author Rodrigo Bravo, Ismael es_ES
dc.contributor.author Ferrando Monleón, Alejandro Ramón es_ES
dc.contributor.author Lisón, Purificación es_ES
dc.date.accessioned 2021-01-26T04:32:20Z
dc.date.available 2021-01-26T04:32:20Z
dc.date.issued 2019-09-19 es_ES
dc.identifier.issn 0305-1048 es_ES
dc.identifier.uri http://hdl.handle.net/10251/159849
dc.description.abstract [EN] Viroids are naked RNAs that do not code for any known protein and yet are able to infect plants causing severe diseases. Because of their RNA nature, many studies have focused on the involvement of viroids in RNA-mediated gene silencing as being their pathogenesis mechanism. Here, the alterations caused by the Citrus exocortis viroid (CEVd) on the tomato translation machinery were studied as a new aspect of viroid pathogenesis. The presence of viroids in the ribosomal fractions of infected tomato plants was detected. More precisely, CEVd and its derived viroid small RNAs were found to co-sediment with tomato ribosomes in vivo, and to provoke changes in the global polysome profiles, particularly in the 40S ribosomal subunit accumulation. Additionally, the viroid caused alterations in ribosome biogenesis in the infected tomato plants, affecting the 18S rRNA maturation process. A higher expression level of the ribosomal stress mediator NAC082 was also detected in the CEVd-infected tomato leaves. Both the alterations in the rRNA processing and the induction of NAC082 correlate with the degree of viroid symptomatology. Taken together, these results suggest that CEVd is responsible for defective ribosome biogenesis in tomato, thereby interfering with the translation machinery and, therefore, causing ribosomal stress. es_ES
dc.description.sponsorship Spanish Ministry of Science, Innovation and Universities [BIO2009-11818, BIO2015-70483-R to A.F.]; Spanish Ministry of Science, Innovation and Universities [BFU2009-11958]; Generalitat Valenciana (Valencia, Spain) [AICO/2017/048]; Natural Sciences and Engineering Research Council of Canada [155219-17 to J.-P.P.]; The RNA group is supported by a grant from the Universite de Sherbrooke; J.-P.P. holds the Research Chair of the Universite de Sherbrooke in RNA Structure and Genomics, and is a member of the Centre de Recherche du CHUS; B.B.-P. was a recipient of a VALi+d postdoctoral contract of the Generalitat Valenciana [APOSTD/2017/039]; Schleiff group is funded through the Deutsche Forschungsgemeinschaft [SFB 902]. Funding for open access charge: Spanish Ministry of Science, Innovation and Universities. es_ES
dc.language Inglés es_ES
dc.publisher Oxford University Press es_ES
dc.relation.ispartof Nucleic Acids Research es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Citrus exocortis viroid causes ribosomal stress in tomato plants es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/nar/gkz679 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BIO2009-11818/ES/Hipusinacion Del Factor Eif5A Y Muerte Celular Inducida Por Estres En Plantas/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSERC//155219-17/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BIO2015-70483-R/ES/PAPEL DE LA ESPERMIDINA Y DE LA BIOSINTESIS DE PROTEINAS EN LA TOLERANCIA DEL POLEN A LAS ALTAS TEMPERATURAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2017%2F039/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/DFG//SFB 902/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BFU2009-11958/ES/Señalizacion Y Respuesta Defensiva De Las Plantas Frente A Patogenos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//AICO%2F2017%2F048/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Cottilli, P.; Belda-Palazón, B.; Adkar-Purushothama, CR.; Perreault, J.; Schleiff, E.; Rodrigo Bravo, I.; Ferrando Monleón, AR.... (2019). Citrus exocortis viroid causes ribosomal stress in tomato plants. Nucleic Acids Research. 47(16):8649-8661. https://doi.org/10.1093/nar/gkz679 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1093/nar/gkz679 es_ES
dc.description.upvformatpinicio 8649 es_ES
dc.description.upvformatpfin 8661 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 47 es_ES
dc.description.issue 16 es_ES
dc.identifier.pmid 31392997 es_ES
dc.identifier.pmcid PMC6895259 es_ES
dc.relation.pasarela S\392474 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Deutsche Forschungsgemeinschaft es_ES
dc.contributor.funder Natural Sciences and Engineering Research Council of Canada es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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