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The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination

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The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination

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dc.contributor.author LOZANO JUSTE, JORGE es_ES
dc.contributor.author Masi, Marco es_ES
dc.contributor.author Cimmino, Alessio es_ES
dc.contributor.author Clement, Suzette es_ES
dc.contributor.author FERNÁNDEZ LÓPEZ, MARIA ANGELES es_ES
dc.contributor.author Antoni, Regina es_ES
dc.contributor.author Meyer, Susan es_ES
dc.contributor.author Rodríguez Egea, Pedro Luís es_ES
dc.contributor.author Evidente, Antonio es_ES
dc.date.accessioned 2021-01-27T04:33:14Z
dc.date.available 2021-01-27T04:33:14Z
dc.date.issued 2019-10-01 es_ES
dc.identifier.issn 0022-0957 es_ES
dc.identifier.uri http://hdl.handle.net/10251/160007
dc.description.abstract [EN] Pyrenophoric acid (P-Acid), P-Acid B, and P-Acid C are three phytotoxic sesquiterpenoids produced by the ascomycete seed pathogen Pyrenophora semeniperda, a fungus proposed as a mycoherbicide for biocontrol of cheatgrass, an extremely invasive weed. When tested in cheatgrass bioassays, these metabolites were able to delay seed germination, with P-Acid B being the most active compound. Here, we have investigated the cross-kingdom activity of P-Acid B and its mode of action, and found that it activates the abscisic acid (ABA) signaling pathway in order to inhibit seedling establishment. P-Acid B inhibits seedling establishment in wild-type Arabidopsis thaliana, while several mutants affected in the early perception as well as in downstream ABA signaling components were insensitive to the fungal compound. However, in spite of structural similarities between ABA and P-Acid B, the latter is not able to activate the PYR/PYL family of ABA receptors. Instead, we have found that P-Acid B uses the ABA biosynthesis pathway at the level of alcohol dehydrogenase ABA2 to reduce seedling establishment. We propose that the fungus P. semeniperda manipulates plant ABA biosynthesis as a strategy to reduce seed germination, increasing its ability to cause seed mortality and thereby increase its fitness through higher reproductive success. es_ES
dc.description.sponsorship This research was funded in part by Grant JFSP-11-S-206 to SM from the Joint Fire Sciences Program of the US Departments of Agriculture and Interior and, in part, to MM, by Programme STAR 2017 financially supported by UniNA and Compagnia di San Paolo. JL-J is funded by a Marie-Sklodowska Curie Reintegration Grant H2020-MSCA-707477. Work in the PLR lab is supported by RTC-2017-6019-2 and BIO201782503-R grants from Ministerio de Ciencia, Innovacion y Universidades. MAF is a recipient of a FPU fellowship from MECD. AE is associated to the Istituto di Chimica Biomolecolare del CNR, Pozzuoli, Italy. We would like to thank Ebe Merilo (University of Tartu) for sharing nced3,5 and aba3-1 mutant seeds. es_ES
dc.language Inglés es_ES
dc.publisher Oxford University Press es_ES
dc.relation.ispartof Journal of Experimental Botany es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject ABA2 es_ES
dc.subject ABA biosynthesis es_ES
dc.subject Abscisic acid es_ES
dc.subject Cross-kingdom activity es_ES
dc.subject Pyrenophora semeniperda es_ES
dc.subject Pyrenophoric acid es_ES
dc.subject Pyrenophoric acid B es_ES
dc.subject Pyrenophoric acid C es_ES
dc.subject PYR/PYL es_ES
dc.subject Seed germination es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/jxb/erz306 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/707477/EU/Drought discovery to improve drought tolerance in crops/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-82503-R/ES/REGULACION DE LA SEÑALIZACION DEL ABA Y TOLERANCIA A SEQUIA MEDIANTE E3 UBIQUITIN LIGASAS QUE REGULAN EL RECAMBIO DE RECEPTORES Y FOSFATASAS 2C/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//RTC-2017-6019-2/ES/Descubrimiento de agroquímicos para mejorar la resistencia a la sequía de plantas de cosecha/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/USDA//JFSP-11-S-206/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Lozano Juste, J.; Masi, M.; Cimmino, A.; Clement, S.; Fernández López, MA.; Antoni, R.; Meyer, S.... (2019). The fungal sesquiterpenoid pyrenophoric acid B uses the plant ABA biosynthetic pathway to inhibit seed germination. Journal of Experimental Botany. 70(19):5487-5494. https://doi.org/10.1093/jxb/erz306 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1093/jxb/erz306 es_ES
dc.description.upvformatpinicio 5487 es_ES
dc.description.upvformatpfin 5494 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 70 es_ES
dc.description.issue 19 es_ES
dc.identifier.pmid 31257433 es_ES
dc.identifier.pmcid PMC6793445 es_ES
dc.relation.pasarela S\403512 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Compagnia di San Paolo es_ES
dc.contributor.funder U.S. Department of Agriculture es_ES
dc.contributor.funder U.S. Department of the Interior es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
dc.contributor.funder Università degli Studi di Napoli Federico II es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
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