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Fibrillatory conduction in a simulated two-dimensional model of human atrial tissue: effect of the interaction of two ectopic foci

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Fibrillatory conduction in a simulated two-dimensional model of human atrial tissue: effect of the interaction of two ectopic foci

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dc.contributor.author Tobón, Catalina es_ES
dc.contributor.author Saiz Rodríguez, Francisco Javier es_ES
dc.date.accessioned 2021-02-03T04:34:19Z
dc.date.available 2021-02-03T04:34:19Z
dc.date.issued 2019-07 es_ES
dc.identifier.issn 0740-6797 es_ES
dc.identifier.uri http://hdl.handle.net/10251/160614
dc.description.abstract [EN] Atrial fibrillation (AF) is the most common tachyarrhythmia. It has been demonstrated that extra-stimuli could act as triggers for AF. In many patients it is possible that multiple ectopic foci co-exist, and their interactions may generate complex conduction patterns. Our goal is to investigate the influence of the focus frequency, conduction velocity, and anisotropy on fibrillatory pattern generation during the interaction of multiple ectopic activities under electrical remodeling conditions. Our results support the broadly accepted theory that ectopic activity acting in remodeled tissue is an initiator of reentrant mechanisms. These reentrant circuits can generate fibrillatory activity when interacting with other rapid ectopic foci and under the following conditions: high ectopic focus frequency, slow conduction velocity, and anisotropic tissue. Analyses of electrogram polymorphism allow determination of which zones of tissue permit one to know in which zone of tissue unstable activity exists. Our results give useful insights into the electrophysiological parameters that determine the initiation and maintenance of fibrillatory conduction by two ectopic foci interaction in a simulated two-dimensional sheet of human atrial cells, under chronic AF conditions. es_ES
dc.description.sponsorship This work was partially supported by the Direccion General de Politica Cientifica de la Generalitat Valenciana (PROMETEU 2016/088) and the University of Medellin es_ES
dc.language Inglés es_ES
dc.publisher SAGE Publications es_ES
dc.relation.ispartof Transactions of the Society for Computer Simulation es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Two-dimensional atrial model es_ES
dc.subject Fibrillatory conduction es_ES
dc.subject Ectopic activity es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Fibrillatory conduction in a simulated two-dimensional model of human atrial tissue: effect of the interaction of two ectopic foci es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1177/0037549718782401 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2016%2F088/ES/MODELOS COMPUTACIONALES PERSONALIZADOS MULTI-ESCALA PARA LA OPTIMIZACION DEL DIAGNOSTICO Y TRATAMIENTO DE ARRITMIAS CARDIACAS (PERSONALISED DIGITAL HEART)/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Tobón, C.; Saiz Rodríguez, FJ. (2019). Fibrillatory conduction in a simulated two-dimensional model of human atrial tissue: effect of the interaction of two ectopic foci. Transactions of the Society for Computer Simulation. 95(7):577-591. https://doi.org/10.1177/0037549718782401 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1177/0037549718782401 es_ES
dc.description.upvformatpinicio 577 es_ES
dc.description.upvformatpfin 591 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 95 es_ES
dc.description.issue 7 es_ES
dc.relation.pasarela S\386403 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
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