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dc.contributor.author | De Santis, Silvia | es_ES |
dc.contributor.author | Moratal, David | es_ES |
dc.contributor.author | Canals, Santiago | es_ES |
dc.date.accessioned | 2021-02-13T04:31:51Z | |
dc.date.available | 2021-02-13T04:31:51Z | |
dc.date.issued | 2019-04-01 | es_ES |
dc.identifier.issn | 0306-4522 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/161202 | |
dc.description.abstract | [EN] The gut-brain axis communicates the brain with the gut microbiota, a bidirectional conduit that has received increasing attention in recent years thanks to its emerging role in brain development and function. Alterations in microbiota composition have been associated to neurological and psychiatric disorders, and several studies suggest that the immune system plays a fundamental role in the gut-brain interaction. Recent advances in brain imaging and in microbiome sequencing have generated a large amount of information, yet the data from both these sources need to be combined efficiently to extract biological meaning, and any diagnostic and/or prognostic benefit from these tools. In addition, the causal nature of the gut-brain interaction remains to be fully established, and preclinical findings translated to humans. In this "Perspective" article, we discuss recent efforts to combine data on the gut microbiota with the features that can be obtained from the conversion of brain images into mineable data. The subsequent analysis of these data for diagnostic and prognostic purposes is an approach we call radiomicrobiomics and it holds tremendous potential to enhance our understanding of this fascinating connection. | es_ES |
dc.description.sponsorship | These studies were supported in part by the Spanish Ministerio de Economia y Competitividad (MINECO) and FEDER funds under grants BFU2015-64380-C2-1-R (S.C.) and BFU2015-64380-C2-2-R (D.M.). This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 668863. S. C. acknowledges financial support from the Spanish State Research Agency, through the "Severo Ochoa" Programme for Centres of Excellence in R&D (ref. SEV-2013-0317). D.M. acknowledges financial support from the Conselleria d'Educacio, Investigacio, Cultura i Esport, Generalitat Valenciana (grant AEST/2017/013). S.D.S was supported by a NARSAD Young Investigator Grant (Grant #: 25104). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Neuroscience | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Advanced MRI | es_ES |
dc.subject | Microbiota | es_ES |
dc.subject | Machine learning | es_ES |
dc.subject | Big data | es_ES |
dc.subject | Gut-brain axis | es_ES |
dc.subject | Radiomicrobiomics | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.neuroscience.2017.11.055 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/668863/EU/Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BFU2015-64380-C2-1-R/ES/TRATAR LA ENFERMEDAD RESINTONIZANDO LA DINAMICA DE LAS REDES CEREBRALES/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//SEV-2013-0317/ES/-/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/BBRF//25104/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BFU2015-64380-C2-2-R/ES/ANALISIS DE TEXTURAS EN IMAGEN CEREBRAL MULTIMODAL POR RESONANCIA MAGNETICA PARA UNA DETECCION TEMPRANA DE ALTERACIONES EN LA RED Y BIOMARCADORES DE ENFERMEDAD/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//AEST%2F2017%2F013/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica | es_ES |
dc.description.bibliographicCitation | De Santis, S.; Moratal, D.; Canals, S. (2019). Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis. Neuroscience. 403:145-149. https://doi.org/10.1016/j.neuroscience.2017.11.055 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.neuroscience.2017.11.055 | es_ES |
dc.description.upvformatpinicio | 145 | es_ES |
dc.description.upvformatpfin | 149 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 403 | es_ES |
dc.identifier.pmid | 29237568 | es_ES |
dc.relation.pasarela | S\405766 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Brain and Behavior Research Foundation | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
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dc.subject.ods | 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades | es_ES |