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Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of E-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier

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Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of E-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier

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dc.contributor.author Guzel Kaya, Gulcihan es_ES
dc.contributor.author Medaglia, Serena es_ES
dc.contributor.author Candela-Noguera, Vicente es_ES
dc.contributor.author Tormo-Mas, María Ángeles es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Deveci, Huseyin es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2021-02-25T04:49:08Z
dc.date.available 2021-02-25T04:49:08Z
dc.date.issued 2020-11 es_ES
dc.identifier.uri http://hdl.handle.net/10251/162358
dc.description.abstract [EN] In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this study, enhancement of linezolid spectrum, normally active against Gram-positive bacteria, was aimed for Gram-negative bacteria growth inhibition. For this purpose, a silica xerogel prepared from a low-cost precursor is used as a drug carrier owing to the advantages of its mesoporous structure, suitable pore and particle size and ultralow density. The silica xerogel is loaded with linezolid and capped with epsilon-poly-l-lysine. The developed nano-formulation shows a marked antibacterial activity against to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. In comparison to free linezolid and epsilon-poly-l-lysine, the material demonstrates a synergistic effect on killing for the three tested bacteria. The results show that silica xerogels can be used as a potential drug carrier and activity enhancer. This strategy could provide the improvement of antibacterial activity spectrum of antibacterial agents like linezolid and could represent a powerful alternative to overcome antibiotic resistance in a near future. es_ES
dc.description.sponsorship We thank the Spanish Government (projects RTI2018-100910-B-C41, RTI2018-101599-B-C22-AR and SAF2017-82251-R (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (project PROMETEO/2018/024) for support. G.G.K. would like to thank Academic Staff Training Program (2016-OYP-071) and TUBITAK for 2214-A International Research Fellowship Program for PhD Students. S.M. thanks Generalitat Valenciana for her Santiago Grisolia fellowship. V.C.-N. thanks Spanish Ministerio de Educacion for his FPU grant (FPU15/02753). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Pharmaceutics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Antibacterial activity es_ES
dc.subject Linezolid es_ES
dc.subject Mesoporous material es_ES
dc.subject Silica xerogel es_ES
dc.subject E-poly-l-lysine es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of E-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/pharmaceutics12111126 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82251-R/ES/NUEVAS ESTRATEGIAS DE PREVENCION Y DIAGNOSTICO DE LAS INFECCIONES RELACIONADAS CON DISPOSITIVOS BIOMEDICOS CAUSADOS POR STAPHYLOCOCCUS SPP/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/TUBITAK//2214-A/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Hacettepe Üniversitesi//2016-OYP-071/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//FPU15%2F02753/ES/FPU15%2F02753/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C22/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Guzel Kaya, G.; Medaglia, S.; Candela-Noguera, V.; Tormo-Mas, MÁ.; Marcos Martínez, MD.; Aznar, E.; Deveci, H.... (2020). Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of E-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier. Pharmaceutics. 12(11):1-14. https://doi.org/10.3390/pharmaceutics12111126 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/pharmaceutics12111126 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 14 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 11 es_ES
dc.identifier.eissn 1999-4923 es_ES
dc.identifier.pmid 33233423 es_ES
dc.identifier.pmcid PMC7700326 es_ES
dc.relation.pasarela S\422276 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Hacettepe Üniversitesi es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Scientific and Technological Research Council of Turkey es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
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