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Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery

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Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery

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dc.contributor.author Poyatos-Racionero, Elisa es_ES
dc.contributor.author González-Álvarez, Isabel es_ES
dc.contributor.author González-Álvarez, Marta es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Bernardos Bau, Andrea es_ES
dc.contributor.author Aznar, Elena es_ES
dc.date.accessioned 2021-02-25T04:49:24Z
dc.date.available 2021-02-25T04:49:24Z
dc.date.issued 2020-07 es_ES
dc.identifier.uri http://hdl.handle.net/10251/162365
dc.description.abstract [EN] In recent decades, the versatility of mesoporous silica particles and their relevance to develop controlled release systems have been demonstrated. Within them, gated materials able to modulate payload delivery represent great advantages. However, the role played by the porous matrix in this kind of systems is scarce. In this work, different mesoporous silica materials (MCM-41, MCM-48, SBA-15 and UVM-7) are functionalized with oleic acid as a molecular gate. All systems are fully characterized and their ability to confine the entrapped cargo and release it in the presence of bile salts is validated with release assays and in vitro digestion experiments. The cargo release profile of each synthesized support is studied, paying attention to the inorganic scaffold. Obtained release profiles fit to Korsmeyer-Peppas model, which explains the differences among the studied supports. Based on the results, UVM-7 material was the most appropriate system for duodenal delivery and was tested in an in vivo model of the Wistar rat. Payload confinement and its complete release after gastric emptying is achieved, establishing the possible use of mesoporous silica particles as protection and direct release agents into the duodenum and, hence, demonstrating that these systems could serve as an alternative to the administration methods employed until now. es_ES
dc.description.sponsorship This research was funded by the Spanish Government (projects RTI2018-100910-B-C41 and RTI2018-101599-B-C22-AR (MCUI/FEDER, EU)) and the Generalitat Valenciana (project PROMETEO/2018/024 and ACIF/2016/023 grant). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Nanomaterials es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Mesoporous silica es_ES
dc.subject Oleic acid es_ES
dc.subject Molecular gate es_ES
dc.subject MCM-41 es_ES
dc.subject MCM-48 es_ES
dc.subject SBA-15 es_ES
dc.subject UVM-7 es_ES
dc.subject Controlled release es_ES
dc.subject Kinetic modelling es_ES
dc.subject Gastrointestinal delivery es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/nano10071290 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACIF%2F2016%2F023/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C22/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Poyatos-Racionero, E.; González-Álvarez, I.; González-Álvarez, M.; Martínez-Máñez, R.; Marcos Martínez, MD.; Bernardos Bau, A.; Aznar, E. (2020). Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery. Nanomaterials. 10(7):1-18. https://doi.org/10.3390/nano10071290 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/nano10071290 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 18 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 7 es_ES
dc.identifier.eissn 2079-4991 es_ES
dc.identifier.pmid 32630076 es_ES
dc.identifier.pmcid PMC7407901 es_ES
dc.relation.pasarela S\414861 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
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