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dc.contributor.author | Dal Bello, Riccardo | es_ES |
dc.contributor.author | Martins, Paulo Magalhaes | es_ES |
dc.contributor.author | Brons, Stephan | es_ES |
dc.contributor.author | Hermann, German | es_ES |
dc.contributor.author | Kihm, Thomas | es_ES |
dc.contributor.author | Seimetz, Michael | es_ES |
dc.contributor.author | Seco, Joao | es_ES |
dc.date.accessioned | 2021-03-01T08:07:56Z | |
dc.date.available | 2021-03-01T08:07:56Z | |
dc.date.issued | 2020-05-07 | es_ES |
dc.identifier.issn | 0031-9155 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/162557 | |
dc.description.abstract | [EN] The physical range uncertainty limits the exploitation of the full potential of charged particle therapy. In this work, we face this issue aiming to measure the absolute Bragg peak position in the target. We investigate p, He-4, C-12 and O-16 beams accelerated at the Heidelberg Ion-Beam Therapy Center. The residual range of the primary C-12 ions is correlated to the energy spectrum of the prompt gamma radiation. The prompt gamma spectroscopy method was demonstrated for proton beams accelerated by cyclotrons and is developed here for the first time for heavier ions accelerated by a synchrotron. We develop a detector system that includes (i) a spectroscopic unit based on cerium(III) bromide and bismuth germanium oxide scintillating crystals, (ii) a beam trigger based on an array of scintillating fibers and (iii) a data acquisition system based on a FlashADC. We test the system in two different scenarios. In the first series of experiments, we detect and identify 19 independent spectral lines over a wide gamma energy spectrum in the presence of the four ion species for different targets, including a water target with a titanium insert. In the second series of experiments, we introduce a collimator aiming to relate the spectral information to the range of the primary particles. We perform extensive measurements for a C-12 beam and demonstrate submillimetric precision for the measurement of its Bragg peak position in the experimental setup. The features of the energy and time spectra for gamma radiation induced by p, He-4 and O-16 are investigated upstream and downstream from the Bragg peak position. We conclude the analysis by extrapolating the required future developments, which would be needed to achieve range verification with a 2 mm accuracy during a single fraction delivery of D=2 Gy<i physical dose. | es_ES |
dc.description.sponsorship | The author R.D.B. is supported by the International Max Planck Research School for Quantum Dynamics in Physics, Chemistry and Biology, Heidelberg, Germany. P.M.M. is supported by a research fellowship for postdoctoral researchers from the Alexander von Humboldt Foundation, Bonn, Germany. The authors thank the Radiation Protection Department of the DKFZ, in particular Mechthild Kammer, for the support with calibration sources. The authors also thank the staff of the Department of Medical Physics in Radiation Oncology of the DKFZ, in particular Gernot Echner, Armin Runz and Peter Haring for the support with the experimental setup. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | IOP Publishing | es_ES |
dc.relation.ispartof | Physics in Medicine and Biology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Prompt gamma | es_ES |
dc.subject | Range verification | es_ES |
dc.subject | Proton therapy | es_ES |
dc.subject | Ion-beam therapy | es_ES |
dc.subject | Charged particle therapy | es_ES |
dc.subject | Radiotherapy | es_ES |
dc.subject | Heidelberg | es_ES |
dc.subject | Ion- Beam Therapy Center | es_ES |
dc.title | Prompt gamma spectroscopy for absolute range verification of 12C ions at synchroton-based facilities | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1088/1361-6560/ab7973 | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular | es_ES |
dc.description.bibliographicCitation | Dal Bello, R.; Martins, PM.; Brons, S.; Hermann, G.; Kihm, T.; Seimetz, M.; Seco, J. (2020). Prompt gamma spectroscopy for absolute range verification of 12C ions at synchroton-based facilities. Physics in Medicine and Biology. 65(9):1-23. https://doi.org/10.1088/1361-6560/ab7973 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1088/1361-6560/ab7973 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 23 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 65 | es_ES |
dc.description.issue | 9 | es_ES |
dc.relation.pasarela | S\412896 | es_ES |
dc.contributor.funder | Max Planck Society | es_ES |
dc.contributor.funder | Alexander von Humboldt Foundation | es_ES |
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