- -

Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Show full item record

González-Gualda, E.; Pàez-Rives, M.; Lozano-Torres, B.; Macias, D.; Wilson Iii, JR.; González-López, C.; Ou, H.... (2020). Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. Aging Cell. 19(4):1-19. https://doi.org/10.1111/acel.13142

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/162597

Files in this item

Item Metadata

Title: Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
Author: González-Gualda, Estela Pàez-Rives, Marta Lozano-Torres, Beatriz Macias, David Wilson III, Joseph R. González-López, Cristina Ou, Hui-Ling MIrón-Barroso, Sofía Zhang, Zhenguang Lérida-Viso, Araceli Blandez, Juan F. Bernardos Bau, Andrea Sancenón Galarza, Félix Rovira, Miguel Fruk, Ljiljana Martins, Carla P. Serrano, Manuel Doherty, Gary J. Martínez-Máñez, Ramón Muñoz-Espín, Daniel
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Abstract:
[EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...[+]
Subjects: Cellular senescence , Chemotherapy-induced senescence , Lung cancer , Navitoclax (ABT-263) , Prodrug , Senolytics , Thrombocytopenia
Copyrigths: Reconocimiento (by)
Source:
Aging Cell. (issn: 1474-9718 )
DOI: 10.1111/acel.13142
Publisher:
Blackwell Publishing
Publisher version: https://doi.org/10.1111/acel.13142
Project ID:
Royal Society/RG160806
...[+]
Royal Society/RG160806
MRC/MR/R000530/1
CRUK/C62187/A26989
CRUK/C62187/A29760
CRUK/RG86786
MINISTERIO DE ECONOMIA Y EMPRESA/IJCI-2014-21534
MECYD/FPU15/02707
GENERALITAT VALENCIANA/PROMETEO/2018/024
AEI/RTI2018-100910-B-C41-AR
[-]
Thanks:
Royal Society, Grant/Award Number: RG160806; Medical Research Council, Grant/Award Number: MR/R000530/1; Cancer Research UK, Grant/Award Number: C62187/A26989 and C62187/A29760; CRUK Cambridge Centre Early Detection ...[+]
Type: Artículo

This item appears in the following Collection(s)

Show full item record