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Beamforming for large-area scan and improved SNR in array-based photoacoustic microscopy

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Beamforming for large-area scan and improved SNR in array-based photoacoustic microscopy

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dc.contributor.author Cebrecos, Alejandro es_ES
dc.contributor.author García-Garrigós, J. J. es_ES
dc.contributor.author Descals, A. es_ES
dc.contributor.author Jimenez, Noe es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author Camarena Femenia, Francisco es_ES
dc.date.accessioned 2021-03-23T04:31:30Z
dc.date.available 2021-03-23T04:31:30Z
dc.date.issued 2021 es_ES
dc.identifier.issn 0041-624X es_ES
dc.identifier.uri http://hdl.handle.net/10251/164058
dc.description.abstract [EN] Beamforming enhances the performance of array-based photoacoustic microscopy (PAM) systems for large-area scan. In this study, we quantify the imaging performance of a large field-of-view optical-resolution photoacoustic-microscopy system using an phased-array detector. The system combines a low-cost pulsed-laser diode with a 128-element linear ultrasound probe. Signal-to-noise ratio (SNR) and generalized contrast-to-noise ratio (gCNR) are quantified using the phased-array detector and applying three beamforming strategies: a no-beamforming method equivalent to a single-element flat transducer, a fixed focus beamforming method that mimics a single-element focused transducer, and a dynamic focus beamforming using a delay-and-sum (DAS) algorithm. The imaging capabilities of the system are demonstrated generating high-resolution images of tissue-mimicking phantoms containing sub-millimetre ink tubes and an ex vivo rabbit¿s ear. The results show that dynamic focus DAS beamforming increases and homogenizes SNR along 1-cm2 images, reaching values up to 15 dB compared to an unfocused detector and up to 30 dB compared to out-of-focus regions of the fixed focus configuration. Moreover, the obtained values of gCNR using the DAS beamformer indicate an excellent target visibility, both on phantoms and ex vivo. This strategy makes it possible to scan larger surfaces compared to standard configurations using single-element detectors, paving the way for advanced array-based PAM systems. es_ES
dc.description.sponsorship This research has been supported by the Spanish Ministry of Science, Innovation and Universities through grant "Juan de la Cierva - Incorporación" (IJC2018-037897-I), and program "Proyectos I+D+i 2019, Spain" (PID2019-111436RB-C22), by Programa Operativo Empleo Juvenil, Spain 2014-2020 (MIN19-VAL-I3M-004), and by the Agència Valenciana de la Innovació, Spain through grant INNCON00/2020/009. Action co-financed by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014-2020 (IDIFEDER/2018/022). A.C. received financial support from Generalitat Valenciana, Spain and Universitat Politècnica de València, Spain through the grants APOSTD/2018/229 and program PAID-10-19, respectively. A.D. received support from Generalitat Valenciana, Spain through grant GJIDI/2018/A/249. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Ultrasonics es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Photoacoustic imaging es_ES
dc.subject OR-PAM es_ES
dc.subject Array-based es_ES
dc.subject DAS beamforming es_ES
dc.subject Large-area scan es_ES
dc.subject Pulsed laser diode es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Beamforming for large-area scan and improved SNR in array-based photoacoustic microscopy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ultras.2020.106317 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AVI//INNCON%2F2020%2F009/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2018%2F229/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ESF//MIN19-VAL-I3M-004/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//AICO%2F2016%2F108/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2018%2FA%2F022/ES/EQUIPOS PARA TECNICAS MIXTAS ELECTROMAGNETICAS-ULTRASONICAS PARA IMAGEN MEDICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GJIDI%2F2018%2FA%2F249/ES/AYUDA GARANTIA JUVENIL GVA-TECNOLOGIA ULTRASONICA PARA APLICACIONES MEDICAS E INDUSTRIALES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AVI//INNCON00%2F18%2F9/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-10-19/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//IJC2018-037897-I/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111436RB-C22/ES/NEW TECHNIQUES FOR MULTIMODAL MOLECULAR ELASTOGRAPHIC IMAGING/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Cebrecos, A.; García-Garrigós, JJ.; Descals, A.; Jimenez, N.; Benlloch Baviera, JM.; Camarena Femenia, F. (2021). Beamforming for large-area scan and improved SNR in array-based photoacoustic microscopy. Ultrasonics. 111:1-8. https://doi.org/10.1016/j.ultras.2020.106317 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.ultras.2020.106317 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 111 es_ES
dc.identifier.pmid 33310407 es_ES
dc.relation.pasarela S\426604 es_ES
dc.contributor.funder European Social Fund es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Agència Valenciana de la Innovació es_ES
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