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dc.contributor.author | Domínguez-Rodríguez, Marcia | es_ES |
dc.contributor.author | Blandez, Juan F. | es_ES |
dc.contributor.author | Lozano-Torres, Beatriz | es_ES |
dc.contributor.author | De La Torre-Paredes, Cristina | es_ES |
dc.contributor.author | Licchelli, Maurizio | es_ES |
dc.contributor.author | Mangano, Carlo | es_ES |
dc.contributor.author | Amendola, Valeria | es_ES |
dc.contributor.author | Sancenón Galarza, Félix | es_ES |
dc.contributor.author | Martínez-Máñez, Ramón | es_ES |
dc.date.accessioned | 2021-03-23T04:31:36Z | |
dc.date.available | 2021-03-23T04:31:36Z | |
dc.date.issued | 2021-01-18 | es_ES |
dc.identifier.issn | 0947-6539 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/164060 | |
dc.description | This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | es_ES |
dc.description.abstract | [EN] Benzene is a highly toxic aromatic hydrocarbon. Inhaling benzene can cause dizziness, vertigo, headaches, aplasia, mutations and, in the most extreme cases, cancer. Trans,trans-muconic acid (t,t-MA) is one of the metabolization products of benzene. Although different analytical methods have been reported for the determination of t,t-MA, these are often expensive, require trained personnel, are not suitable for on-site measurements, and use hazardous organic solvents. For these reasons, the development of reliable, selective and sensitive methods for rapid and in situ detection of t,t-MA are of importance. Addressing this challenge, a nanodevice for the selective and sensitive quantification of t,t-MA in urine is reported. The nanodevice used is achieved using mesoporous silica nanoparticles loaded with a dye reporter and capped with a dicopper(II) azacryptand. Pore opening and payload release is induced rapidly (10 min) and selectively with t,t-MA in urine, using a simple fluorimeter without sample pretreatment. | es_ES |
dc.description.sponsorship | The authors thank the Spanish Government (RTI2018-100910-B-C41) and the Generalitat Valenciana (PROMETEO 2018/024) for support. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | Chemistry - A European Journal | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Benzene | es_ES |
dc.subject | Hybrid organic-inorganic materials | es_ES |
dc.subject | Mesoporous materials | es_ES |
dc.subject | Molecular recognition | es_ES |
dc.subject | Nanoprobe | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.title | A Nanoprobe Based on Gated Mesoporous Silica Nanoparticles for The Selective and Sensitive Detection of Benzene Metabolite t,t-Muconic Acid in Urine | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/chem.202004272 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Domínguez-Rodríguez, M.; Blandez, JF.; Lozano-Torres, B.; De La Torre-Paredes, C.; Licchelli, M.; Mangano, C.; Amendola, V.... (2021). A Nanoprobe Based on Gated Mesoporous Silica Nanoparticles for The Selective and Sensitive Detection of Benzene Metabolite t,t-Muconic Acid in Urine. Chemistry - A European Journal. 27(4):1306-1310. https://doi.org/10.1002/chem.202004272 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/chem.202004272 | es_ES |
dc.description.upvformatpinicio | 1306 | es_ES |
dc.description.upvformatpfin | 1310 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 27 | es_ES |
dc.description.issue | 4 | es_ES |
dc.relation.pasarela | S\427725 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
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