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Genomic regions influencing intramuscular fat in divergently selected rabbit lines

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Genomic regions influencing intramuscular fat in divergently selected rabbit lines

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dc.contributor.author Sosa-Madrid, Bolivar Samuel es_ES
dc.contributor.author Hernández, Pilar es_ES
dc.contributor.author Blasco Mateu, Agustín es_ES
dc.contributor.author Haley, Chris S. es_ES
dc.contributor.author Fontanesi, Luca es_ES
dc.contributor.author Santacreu Jerez, María Antonia es_ES
dc.contributor.author Pena, Romi N. es_ES
dc.contributor.author Navarro, Pau es_ES
dc.contributor.author Ibáñez-Escriche, Noelia es_ES
dc.date.accessioned 2021-04-17T03:32:34Z
dc.date.available 2021-04-17T03:32:34Z
dc.date.issued 2020-02 es_ES
dc.identifier.issn 0268-9146 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165281
dc.description.abstract [EN] Intramuscular fat (IMF) is one of the main meat quality traits for breeding programs in livestock species. The main objective of this study was to identify genomic regions associated with IMF content comparing two rabbit populations divergently selected for this trait, and to generate a list of putative candidate genes. Animals were genotyped using the Affymetrix Axiom OrcunSNP Array (200k). After quality control, the data involved 477 animals and 93,540 single nucleotide polymorphisms (SNPs). Two methods were used in this research: single marker regressions with the data adjusted by genomic relatedness, and a Bayesian multi-marker regression. Associated genomic regions were located on the rabbit chromosomes (OCU) OCU1, OCU8 and OCU13. The highest value for the percentage of the genomic variance explained by a genomic region was found in two consecutive genomic windows on OCU8 (7.34%). Genes in the associated regions of OCU1 and OCU8 presented biological functions related to the control of adipose cell function, lipid binding, transportation and localization (APOLD1, PLBD1, PDE6H, GPRC5D, and GPRC5A) and lipid metabolic processes (MTMR2). The EWSR1 gene, underlying the OCU13 region, is linked to the development of brown adipocytes. The findings suggest that there is a large component of polygenic effect behind the differences in IMF content in these two lines, as the variance explained by most of the windows was low. The genomic regions of OCU1, OCU8 and OCU13 revealed novel candidate genes. Further studies would be needed to validate the associations and explore their possible application in selection programs. es_ES
dc.description.sponsorship The work was funded by project AGL2014-55921-C2-1-P from National Programme for Fostering Excellence in Scientific and Technical Research -Project I+D. BSS was supported by a FPI grant from the Ministry of Economy and Competitiveness of Spain+ (BES-2015-074194). NIB was supported with a "Ramon y Cajal" grant provided by Ministerio de Ciencia e Innovacion (RYC-2016-19764). CSH and PN were supported by the Medical Research Council (United kingdom, grants MC_PC_U127592696 and MC_PC_U127561128). CSH was supported by Biotechnology and Biological Sciences Research Council (United Kingdom, Grant/Award Number: BBS/E/D/30002276). es_ES
dc.language Inglés es_ES
dc.publisher Blackwell Publishing es_ES
dc.relation.ispartof Animal Genetics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Divergent selection es_ES
dc.subject Genome-wide association study es_ES
dc.subject Intramuscular fat es_ES
dc.subject Meat quality es_ES
dc.subject Rabbits es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Genomic regions influencing intramuscular fat in divergently selected rabbit lines es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/age.12873 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UKRI//BBS%2FE%2FD%2F30002276/GB/Complex phenotypes and genotype x environment interactions/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UKRI//MC_PC_U127592696/GB/The Genetics of Complex and Quantitative Traits/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UKRI//MC_PC_U127561128/GB/Quantitative trait locus (QTL) identification in a Croatian isolate/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2014-55921-C2-1-P/ES/ESTUDIO GENOMICO Y METABOLOMICO DE VARIAS LINEAS DE SELECCION DIVERGENTE EN CONEJO: EL CONEJO COMO MODELO EXPERIMENTAL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-074194/ES/BES-2015-074194/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RYC-2016-19764/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Sosa-Madrid, BS.; Hernández, P.; Blasco Mateu, A.; Haley, CS.; Fontanesi, L.; Santacreu Jerez, MA.; Pena, RN.... (2020). Genomic regions influencing intramuscular fat in divergently selected rabbit lines. Animal Genetics. 51:58-69. https://doi.org/10.1111/age.12873 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1111/age.12873 es_ES
dc.description.upvformatpinicio 58 es_ES
dc.description.upvformatpfin 69 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 51 es_ES
dc.identifier.pmid 31696970 es_ES
dc.identifier.pmcid PMC7004202 es_ES
dc.relation.pasarela S\393725 es_ES
dc.contributor.funder UK Research and Innovation es_ES
dc.contributor.funder Medical Research Council, Reino Unido es_ES
dc.contributor.funder Biotechnology and Biological Sciences Research Council, Reino Unido es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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