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Photoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates

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Photoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates

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dc.contributor.author Francés-Monerris, Antonio es_ES
dc.contributor.author Lineros-Rosa, Mauricio es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Lhiaubet, Virginie Lyria es_ES
dc.contributor.author Monari, Antonio es_ES
dc.date.accessioned 2021-04-21T03:31:44Z
dc.date.available 2021-04-21T03:31:44Z
dc.date.issued 2020-04-25 es_ES
dc.identifier.issn 1359-7345 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165411
dc.description.abstract [EN] The propensity of 5-formyluracil and 5-formylcytosine, i.e. oxidative lesions and epigenetic intermediates, in acting as intrinsic DNA photosensitizers is unraveled by using a combination of molecular modeling, simulation and spectroscopy. Exploration of potential energy surfaces and non-adiabatic dynamics confirm a higher intersystem crossing rate for 5-formyluracil, whereas the kinetic models evidence different equilibria in the excited states for both compounds. es_ES
dc.description.sponsorship Support from the Universite de Lorraine, CNRS and Spanish Government (PGC2018-096684-B-I00) is kindly acknowledged. A. F.-M. is grateful to Generalitat Valenciana (CTQ2017-87054-C2-2-P) and the European Social Fund for a postdoctoral contract (APOSTD/2019/149), M. L.-R. acknowledges the Universitat Politecnica de Valencia for the FPI grant. Calculations have been performed on the local LPCT computer center and on the Explor regional center in the framework of the project "Dancing under the light''. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Chemical Communications es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Photoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/d0cc01132k es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87054-C2-2-P/ES/FOTOFISICA DE SISTEMAS ORGANICOS DE TRANSFERENCIA DE CARGA INNOVADORES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-096684-B-I00/ES/REPARACION DEL ADN POR PROCESOS MULTIFOTONICOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2019%2F149/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Francés-Monerris, A.; Lineros-Rosa, M.; Miranda Alonso, MÁ.; Lhiaubet, VL.; Monari, A. (2020). Photoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates. Chemical Communications. 56(32):4404-4407. https://doi.org/10.1039/d0cc01132k es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/d0cc01132k es_ES
dc.description.upvformatpinicio 4404 es_ES
dc.description.upvformatpfin 4407 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 56 es_ES
dc.description.issue 32 es_ES
dc.identifier.pmid 32239074 es_ES
dc.relation.pasarela S\425469 es_ES
dc.contributor.funder European Social Fund es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Université de Lorraine es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Centre National de la Recherche Scientifique, Francia es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
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