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Novel Genomic Regions Associated with Intramuscular Fatty Acid Composition in Rabbits

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Novel Genomic Regions Associated with Intramuscular Fatty Acid Composition in Rabbits

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dc.contributor.author Laghouaouta, Houda es_ES
dc.contributor.author Sosa-Madrid, Bolivar Samuel es_ES
dc.contributor.author Zubiri-Gaitán, Agostina es_ES
dc.contributor.author Hernández, Pilar es_ES
dc.contributor.author Blasco Mateu, Agustín es_ES
dc.date.accessioned 2021-04-22T03:31:40Z
dc.date.available 2021-04-22T03:31:40Z
dc.date.issued 2020-11 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165486
dc.description.abstract [EN] A divergent selection experiment on intramuscular fat (IMF) content was carried out during nine generations in rabbits. The IMF content was successfully improved through generations. Besides, selection for IMF content generated a correlated response on its composition. Association analyses were performed to understand the genetic background of IMF composition using two rabbit lines divergently selected for IMF content. Several genomic regions and genes were identified, revealing the polygenic nature of the intramuscular fatty acid composition in rabbits. Intramuscular fat (IMF) content and its composition affect the quality of meat. Selection for IMF generated a correlated response on its fatty acid composition. The increase of IMF content is associated with an increase of its saturated (SFA) and monounsaturated (MUFA) fatty acids, and consequently a decrease of polyunsaturated fatty acids (PUFA). We carried out a genome wide association study (GWAS) for IMF composition on two rabbit lines divergently selected for IMF content, using a Bayes B procedure. Association analyses were performed using 475 individuals and 90,235 Single Nucleotide Polymorphisms (SNPs). The main objectives were to identify genomic regions associated with the IMF composition and to generate a list of candidate genes. Genomic regions associated with the intramuscular fatty acid composition were spread across different rabbit chromosomes (OCU). An important region at 34.0-37.9 Mb on OCU1 was associated with C14:0, C16:0, SFA, and C18:2n6, explaining 3.5%, 11.2%, 11.3%, and 3.2% of the genomic variance, respectively. Another relevant genomic region was found to be associated at 46.0-48.9 Mb on OCU18, explaining up to 8% of the genomic variance of MUFA/SFA. The associated regions harbor several genes related to lipid metabolism, such as SCD, PLIN2, and ERLIN1. The main genomic regions associated with the fatty acids were not previously associated with IMF content in rabbits. Nonetheless, MTMR2 is the only gene that was associated with both the IMF content and composition in rabbits. Our study highlighted the polygenic nature of the fatty acids in rabbits and elucidated its genetic background. es_ES
dc.description.sponsorship The work was funded by project AGL2014-55921-C2-1-P and AGL2017-86083-C2-P1 from Plan Nacional de Investigacion Cientifica of Spain-Project I+D. B. Samuel Sosa-Madrid was supported by a FPI grant from Ministerio de Ciencia e Innovacion of Spain (BES-2015-074194). Houda Laghouaouta was supported by a scholarship from the Mediterranean Agronomic Institute of Zaragoza. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Animals es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Intramuscular fat es_ES
dc.subject Fatty acids es_ES
dc.subject Divergent selection es_ES
dc.subject Genome-wide association study es_ES
dc.subject Rabbits es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Novel Genomic Regions Associated with Intramuscular Fatty Acid Composition in Rabbits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/ani10112090 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2014-55921-C2-1-P/ES/ESTUDIO GENOMICO Y METABOLOMICO DE VARIAS LINEAS DE SELECCION DIVERGENTE EN CONEJO: EL CONEJO COMO MODELO EXPERIMENTAL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-074194/ES/BES-2015-074194/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-86083-C2-1-P/ES/ESTUDIO MULTIOMICO SOBRE SENSIBILIDAD AMBIENTAL, LONGEVIDAD Y DEPOSICION GRASA EN LINEAS SELECCIONADAS DE CONEJO/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Laghouaouta, H.; Sosa-Madrid, BS.; Zubiri-Gaitán, A.; Hernández, P.; Blasco Mateu, A. (2020). Novel Genomic Regions Associated with Intramuscular Fatty Acid Composition in Rabbits. Animals. 10(11):1-17. https://doi.org/10.3390/ani10112090 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/ani10112090 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 11 es_ES
dc.identifier.eissn 2076-2615 es_ES
dc.identifier.pmid 33187110 es_ES
dc.identifier.pmcid PMC7697864 es_ES
dc.relation.pasarela S\434537 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Instituto Agronómico Mediterráneo de Zaragoza es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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