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Pathogenesis of Intradermal Staphylococcal Infections Rabbit Experimental Approach to Natural Staphylococcus aureus Skin Infections

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Pathogenesis of Intradermal Staphylococcal Infections Rabbit Experimental Approach to Natural Staphylococcus aureus Skin Infections

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Muñoz-Silvestre, A.; Penadés, M.; Selva, L.; Pérez-Fuentes, S.; Moreno Grua, E.; García-Quirós, A.; Pascual Amorós, JJ.... (2020). Pathogenesis of Intradermal Staphylococcal Infections Rabbit Experimental Approach to Natural Staphylococcus aureus Skin Infections. The American Journal of Pathology. 190(6):1188-1210. https://doi.org/10.1016/j.ajpath.2020.01.019

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Title: Pathogenesis of Intradermal Staphylococcal Infections Rabbit Experimental Approach to Natural Staphylococcus aureus Skin Infections
Author: Muñoz-Silvestre, A. Penadés, Mariola Selva, L. Pérez-Fuentes, S. Moreno Grua, E. García-Quirós, Ana Pascual Amorós, Juan José Arnau-Bonachera, Alberto Barragán, A. CORPA, JUAN MANUEL Viana, David
UPV Unit: Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal
Issued date:
[EN] Despite the enormous efforts made to achieve effective tools that fight against Staphylococcus aureus, the results have not been successful. This failure may be due to the absence of truly representative experimental ...[+]
Subjects: Phenol-Soluble modulins , Virulence determinants , Toxin , Expression , Animals , Models , Immune , Gene
Copyrigths: Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
The American Journal of Pathology. (issn: 0002-9440 )
DOI: 10.1016/j.ajpath.2020.01.019
Publisher version: https://doi.org/10.1016/j.ajpath.2020.01.019
Project ID:
Supported by the Spanish Ministry of Economy and Competitiveness (MINECO) grant AGL2014-53405-C2-2-P, the Universidad CEU Cardenal Herrera, and European Union Development Fund (FEDER) Programme PO FEDER 2007-2013. A.M.-S., ...[+]
Type: Artículo


Kobayashi, S. D., Malachowa, N., & DeLeo, F. R. (2015). Pathogenesis of Staphylococcus aureus Abscesses. The American Journal of Pathology, 185(6), 1518-1527. doi:10.1016/j.ajpath.2014.11.030

Lowy, F. D. (2011). HowStaphylococcus aureusAdapts to Its Host. New England Journal of Medicine, 364(21), 1987-1990. doi:10.1056/nejmp1100251

Peschel, A., & Otto, M. (2013). Phenol-soluble modulins and staphylococcal infection. Nature Reviews Microbiology, 11(10), 667-673. doi:10.1038/nrmicro3110 [+]
Kobayashi, S. D., Malachowa, N., & DeLeo, F. R. (2015). Pathogenesis of Staphylococcus aureus Abscesses. The American Journal of Pathology, 185(6), 1518-1527. doi:10.1016/j.ajpath.2014.11.030

Lowy, F. D. (2011). HowStaphylococcus aureusAdapts to Its Host. New England Journal of Medicine, 364(21), 1987-1990. doi:10.1056/nejmp1100251

Peschel, A., & Otto, M. (2013). Phenol-soluble modulins and staphylococcal infection. Nature Reviews Microbiology, 11(10), 667-673. doi:10.1038/nrmicro3110

Von Eiff, C., Becker, K., Machka, K., Stammer, H., & Peters, G. (2001). Nasal Carriage as a Source ofStaphylococcus aureusBacteremia. New England Journal of Medicine, 344(1), 11-16. doi:10.1056/nejm200101043440102

Saïd-Salim, B., Dunman, P. M., McAleese, F. M., Macapagal, D., Murphy, E., McNamara, P. J., … Kreiswirth, B. N. (2003). Global Regulation of Staphylococcus aureus Genes by Rot. Journal of Bacteriology, 185(2), 610-619. doi:10.1128/jb.185.2.610-619.2003

Gao, J., & Stewart, G. C. (2004). Regulatory Elements of the Staphylococcus aureus Protein A (Spa) Promoter. Journal of Bacteriology, 186(12), 3738-3748. doi:10.1128/jb.186.12.3738-3748.2004

Fridkin, S. K., Hageman, J. C., Morrison, M., Sanza, L. T., Como-Sabetti, K., Jernigan, J. A., … Farley, M. M. (2005). Methicillin-ResistantStaphylococcus aureusDisease in Three Communities. New England Journal of Medicine, 352(14), 1436-1444. doi:10.1056/nejmoa043252

DeLeo, F. R., Otto, M., Kreiswirth, B. N., & Chambers, H. F. (2010). Community-associated meticillin-resistant Staphylococcus aureus. The Lancet, 375(9725), 1557-1568. doi:10.1016/s0140-6736(09)61999-1

Talan, D. A., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., Limbago, B., … Albrecht, V. (2011). Comparison of Staphylococcus aureus From Skin and Soft-Tissue Infections in US Emergency Department Patients, 2004 and 2008. Clinical Infectious Diseases, 53(2), 144-149. doi:10.1093/cid/cir308

Bae, I.-G., Tonthat, G. T., Stryjewski, M. E., Rude, T. H., Reilly, L. F., Barriere, S. L., … Fowler, V. G. (2009). Presence of Genes Encoding the Panton-Valentine Leukocidin Exotoxin Is Not the Primary Determinant of Outcome in Patients with Complicated Skin and Skin Structure Infections Due to Methicillin-Resistant Staphylococcus aureus  : Results of a Multinational Trial. Journal of Clinical Microbiology, 47(12), 3952-3957. doi:10.1128/jcm.01643-09

Kennedy, A. D., Wardenburg, J. B., Gardner, D. J., Long, D., Whitney, A. R., Braughton, K. R., … DeLeo, F. R. (2010). Targeting of Alpha‐Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model. The Journal of Infectious Diseases, 202(7), 1050-1058. doi:10.1086/656043

Viana, D., Selva, L., Segura, P., Penadés, J. R., & Corpa, J. M. (2007). Genotypic characterization of Staphylococcus aureus strains isolated from rabbit lesions. Veterinary Microbiology, 121(3-4), 288-298. doi:10.1016/j.vetmic.2006.12.003

Viana, D., Comos, M., McAdam, P. R., Ward, M. J., Selva, L., Guinane, C. M., … Penadés, J. R. (2015). A single natural nucleotide mutation alters bacterial pathogen host tropism. Nature Genetics, 47(4), 361-366. doi:10.1038/ng.3219

Jung, E. C., & Maibach, H. I. (2014). Animal models for percutaneous absorption. Journal of Applied Toxicology, 35(1), 1-10. doi:10.1002/jat.3004

Malachowa, N., Kobayashi, S. D., Porter, A. R., Braughton, K. R., Scott, D. P., Gardner, D. J., … DeLeo, F. R. (2016). Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection. PLOS ONE, 11(6), e0158293. doi:10.1371/journal.pone.0158293

Le, V. T. M., Tkaczyk, C., Chau, S., Rao, R. L., Dip, E. C., Pereira-Franchi, E. P., … Diep, B. A. (2016). Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections. Antimicrobial Agents and Chemotherapy, 60(10), 5640-5648. doi:10.1128/aac.00710-16

Otto, M. (2014). Staphylococcus aureus toxins. Current Opinion in Microbiology, 17, 32-37. doi:10.1016/j.mib.2013.11.004

Collins, L. V., Kristian, S. A., Weidenmaier, C., Faigle, M., van Kessel, K. P. M., van Strijp, J. A. G., … Peschel, A. (2002). Staphylococcus aureusStrains Lackingd‐Alanine Modifications of Teichoic Acids Are Highly Susceptible to Human Neutrophil Killing and Are Virulence Attenuated in Mice. The Journal of Infectious Diseases, 186(2), 214-219. doi:10.1086/341454

Novick, R. P. (1991). [27] Genetic systems in Staphylococci. Bacterial Genetic Systems, 587-636. doi:10.1016/0076-6879(91)04029-n

Lindsay, J. A., Ruzin, A., Ross, H. F., Kurepina, N., & Novick, R. P. (1998). The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands inStaphylococcus aureus. Molecular Microbiology, 29(2), 527-543. doi:10.1046/j.1365-2958.1998.00947.x

Arnaud, M., Chastanet, A., & Débarbouillé, M. (2004). New Vector for Efficient Allelic Replacement in Naturally Nontransformable, Low-GC-Content, Gram-Positive Bacteria. Applied and Environmental Microbiology, 70(11), 6887-6891. doi:10.1128/aem.70.11.6887-6891.2004

Úbeda, C., Maiques, E., Knecht, E., Lasa, Í., Novick, R. P., & Penadés, J. R. (2005). Antibiotic-induced SOS response promotes horizontal dissemination of pathogenicity island-encoded virulence factors in staphylococci. Molecular Microbiology, 56(3), 836-844. doi:10.1111/j.1365-2958.2005.04584.x

Li, M., Cheung, G. Y. C., Hu, J., Wang, D., Joo, H., DeLeo, F. R., & Otto, M. (2010). Comparative Analysis of Virulence and Toxin Expression of Global Community‐Associated Methicillin‐ResistantStaphylococcus aureusStrains. The Journal of Infectious Diseases, 202(12), 1866-1876. doi:10.1086/657419

Bunce, C., Wheeler, L., Reed, G., Musser, J., & Barg, N. (1992). Murine model of cutaneous infection with gram-positive cocci. Infection and Immunity, 60(7), 2636-2640. doi:10.1128/iai.60.7.2636-2640.1992

Voyich, J. M., Otto, M., Mathema, B., Braughton, K. R., Whitney, A. R., Welty, D., … DeLeo, F. R. (2006). Is Panton‐Valentine Leukocidin the Major Virulence Determinant in Community‐Associated Methicillin‐ResistantStaphylococcus aureusDisease? The Journal of Infectious Diseases, 194(12), 1761-1770. doi:10.1086/509506

Jeklova, E., Leva, L., & Faldyna, M. (2007). Lymphoid organ development in rabbits: Major lymphocyte subsets. Developmental & Comparative Immunology, 31(6), 632-644. doi:10.1016/j.dci.2006.10.002

Guerrero, I., Ferrian, S., Blas, E., Pascual, J. J., Cano, J. L., & Corpa, J. M. (2011). Evolution of the peripheral blood lymphocyte populations in multiparous rabbit does with two reproductive management rhythms. Veterinary Immunology and Immunopathology, 140(1-2), 75-81. doi:10.1016/j.vetimm.2010.11.017

Hulstaert, F., Hannet, I., Deneys, V., Munhyeshuli, V., Reichert, T., De Bruyere, M., & Strauss, K. (1994). Age-Related Changes in Human Blood Lymphocyte Subpopulations. Clinical Immunology and Immunopathology, 70(2), 152-158. doi:10.1006/clin.1994.1023

Armand-Lefevre, L., Ruimy, R., & Andremont, A. (2005). Clonal Comparison ofStaphylococcus aureusIsolates from Healthy Pig Farmers, Human Controls, and Pigs. Emerging Infectious Diseases, 11(5), 711-714. doi:10.3201/eid1105.040866

Graveland, H., Duim, B., van Duijkeren, E., Heederik, D., & Wagenaar, J. A. (2011). Livestock-associated methicillin-resistant Staphylococcus aureus in animals and humans. International Journal of Medical Microbiology, 301(8), 630-634. doi:10.1016/j.ijmm.2011.09.004

Aires-de-Sousa, M. (2017). Methicillin-resistant Staphylococcus aureus among animals: current overview. Clinical Microbiology and Infection, 23(6), 373-380. doi:10.1016/j.cmi.2016.11.002

Moreno-Grúa, E., Pérez-Fuentes, S., Muñoz-Silvestre, A., Viana, D., Fernández-Ros, A. B., Sanz-Tejero, C., … Selva, L. (2018). Characterization of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Isolates Obtained From Commercial Rabbitries Located in the Iberian Peninsula. Frontiers in Microbiology, 9. doi:10.3389/fmicb.2018.01812

Viana, D., Selva, L., Callanan, J. J., Guerrero, I., Ferrian, S., & Corpa, J. M. (2011). Strains of Staphylococcus aureus and pathology associated with chronic suppurative mastitis in rabbits. The Veterinary Journal, 190(3), 403-407. doi:10.1016/j.tvjl.2010.11.022

Cheng, A. G., DeDent, A. C., Schneewind, O., & Missiakas, D. (2011). A play in four acts: Staphylococcus aureus abscess formation. Trends in Microbiology, 19(5), 225-232. doi:10.1016/j.tim.2011.01.007

Chen, X., Du, Y., Lin, X., Qian, Y., Zhou, T., & Huang, Z. (2016). CD4 + CD25 + regulatory T cells in tumor immunity. International Immunopharmacology, 34, 244-249. doi:10.1016/j.intimp.2016.03.009

Bekeredjian-Ding, I. (2017). Deciphering the significance of the T-cell response to Staphylococcus aureus. Future Microbiology, 12(12), 1023-1026. doi:10.2217/fmb-2017-0138

Krishna, S., & Miller, L. S. (2011). Innate and adaptive immune responses against Staphylococcus aureus skin infections. Seminars in Immunopathology, 34(2), 261-280. doi:10.1007/s00281-011-0292-6

Liu, Q., Mazhar, M., & Miller, L. S. (2018). Immune and Inflammatory Reponses to Staphylococcus aureus Skin Infections. Current Dermatology Reports, 7(4), 338-349. doi:10.1007/s13671-018-0235-8

Miller, L. S., & Cho, J. S. (2011). Immunity against Staphylococcus aureus cutaneous infections. Nature Reviews Immunology, 11(8), 505-518. doi:10.1038/nri3010

Terada, M., Tsutsui, H., Imai, Y., Yasuda, K., Mizutani, H., Yamanishi, K., … Nakanishi, K. (2006). Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice. Proceedings of the National Academy of Sciences, 103(23), 8816-8821. doi:10.1073/pnas.0602900103

Syed, A. K., Reed, T. J., Clark, K. L., Boles, B. R., & Kahlenberg, J. M. (2015). Staphlyococcus aureus Phenol-Soluble Modulins Stimulate the Release of Proinflammatory Cytokines from Keratinocytes and Are Required for Induction of Skin Inflammation. Infection and Immunity, 83(9), 3428-3437. doi:10.1128/iai.00401-15

Laouini, D., Kawamoto, S., Yalcindag, A., Bryce, P., Mizoguchi, E., Oettgen, H., & Geha, R. S. (2003). Epicutaneous sensitization with superantigen induces allergic skin inflammation. Journal of Allergy and Clinical Immunology, 112(5), 981-987. doi:10.1016/j.jaci.2003.07.007

Holtfreter, S., Radcliff, F. J., Grumann, D., Read, H., Johnson, S., Monecke, S., … Wiles, S. (2013). Characterization of a Mouse-Adapted Staphylococcus aureus Strain. PLoS ONE, 8(9), e71142. doi:10.1371/journal.pone.0071142

Kobayashi, S. D., Malachowa, N., Whitney, A. R., Braughton, K. R., Gardner, D. J., Long, D., … DeLeo, F. R. (2011). Comparative Analysis of USA300 Virulence Determinants in a Rabbit Model of Skin and Soft Tissue Infection. The Journal of Infectious Diseases, 204(6), 937-941. doi:10.1093/infdis/jir441

Schmid-Hempel, P., & Frank, S. A. (2007). Pathogenesis, Virulence, and Infective Dose. PLoS Pathogens, 3(10), e147. doi:10.1371/journal.ppat.0030147

Inoshima, N., Wang, Y., & Bubeck Wardenburg, J. (2012). Genetic Requirement for ADAM10 in Severe Staphylococcus aureus Skin Infection. Journal of Investigative Dermatology, 132(5), 1513-1516. doi:10.1038/jid.2011.462

Tkaczyk, C., Hamilton, M. M., Datta, V., Yang, X. P., Hilliard, J. J., Stephens, G. L., … Sellman, B. R. (2013). Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model. PLoS ONE, 8(10), e75103. doi:10.1371/journal.pone.0075103

Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., … Otto, M. (2007). Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nature Medicine, 13(12), 1510-1514. doi:10.1038/nm1656

Recsei, P., Kreiswirth, B., O’Reilly, M., Schlievert, P., Gruss, A., & Novick, R. P. (1986). Regulation of exoprotein gene expression in Staphylococcus aureus by agr. Molecular and General Genetics MGG, 202(1), 58-61. doi:10.1007/bf00330517

Rainard, P., Gitton, C., Chaumeil, T., Fassier, T., Huau, C., Riou, M., … Martin, P. (2018). Host factors determine the evolution of infection with Staphylococcus aureus to gangrenous mastitis in goats. Veterinary Research, 49(1). doi:10.1186/s13567-018-0564-4

Salam, A. M., & Quave, C. L. (2018). Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In Vivo. mSphere, 3(1). doi:10.1128/msphere.00500-17

Cheng, A. G., Kim, H. K., Burts, M. L., Krausz, T., Schneewind, O., & Missiakas, D. M. (2009). Genetic requirements forStaphylococcus aureusabscess formation and persistence in host tissues. The FASEB Journal, 23(10), 3393-3404. doi:10.1096/fj.09-135467

Cheng, A. G., McAdow, M., Kim, H. K., Bae, T., Missiakas, D. M., & Schneewind, O. (2010). Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLoS Pathogens, 6(8), e1001036. doi:10.1371/journal.ppat.1001036

Kim, H. K., Missiakas, D., & Schneewind, O. (2014). Mouse models for infectious diseases caused by Staphylococcus aureus. Journal of Immunological Methods, 410, 88-99. doi:10.1016/j.jim.2014.04.007




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