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Axonal extension from dorsal root ganglia on fibrillar and highly aligned poly(lactic acid)-polypyrrole substrates obtained by two different techniques: Electrospun nanofibres and extruded microfibres

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Axonal extension from dorsal root ganglia on fibrillar and highly aligned poly(lactic acid)-polypyrrole substrates obtained by two different techniques: Electrospun nanofibres and extruded microfibres

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dc.contributor.author Gisbert-Roca, Fernando es_ES
dc.contributor.author Más Estellés, Jorge es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.date.accessioned 2021-04-27T03:33:06Z
dc.date.available 2021-04-27T03:33:06Z
dc.date.issued 2020-11-15 es_ES
dc.identifier.issn 0141-8130 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165608
dc.description.abstract [EN] The biological behaviour of Schwann cells (SCs) and dorsal root ganglia (DRG) on fibrillar, highly aligned and electroconductive substrates obtained by two different techniques is studied. Mats formed by nanometer-sized fibres of poly(lactic acid) (PLA) are obtained by the electrospinning technique, while bundles formed by micrometer-sized extruded PLA fibres are obtained by grouping microfibres together. Both types of substrates are coated with the electrically conductive polymer polypyrrole (PPy) and their morphological, physical and electrical characterization is carried out. SCs on micrometer-sized substrates show a higher motility and cell-cell interaction, while a higher cell-material interaction with a lower cell motility is observed for nanometer-sized substrates. This higher motility and cell-cell interaction of SCs on the micrometer-sized substrates entails a higher axonal growth from DRG, since the migration of SCs from the DRG body is accelerated and, therefore, the SCs tapestry needed for the axonal growth is formed earlier on the substrate. A higher length and area of the axons is observed for these micrometer-sized substrates, as well as a higher level of axonal sprouting when compared with the nanometer-sized ones. These substrates offer the possibility of being electrically stimulated in different tissue engineering applications of the nervous system. es_ES
dc.description.sponsorship The authors acknowledge financing from the Spanish Government's State Research Agency (AEI) through projects DPI2015-72863-EXP and RTI2018-095872-B-C22/ERDF. FGR acknowledges scholarship FPU16/01833 of the Spanish Ministry of Universities. We thank the Electron Microscopy Service at the UPV, where the FESEM images were obtained es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation AGENCIA ESTATAL DE INVESTIGACION/DPI2015-72863-EXP es_ES
dc.relation MECYD/FPU16/01833 es_ES
dc.relation info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095872-B-C22/ES/NUEVO DISPOSITIVO BIOACTIVO PARA LA REGENERACION DE LESIONES DE LA MEDULA ESPINAL./ es_ES
dc.relation.ispartof International Journal of Biological Macromolecules es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Poly(lactic acid) es_ES
dc.subject Polypyrrole es_ES
dc.subject Aligned substrates es_ES
dc.subject Biological behaviour es_ES
dc.subject Schwann cells es_ES
dc.subject Dorsal root ganglia es_ES
dc.subject.classification TERMODINAMICA APLICADA (UPV) es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Axonal extension from dorsal root ganglia on fibrillar and highly aligned poly(lactic acid)-polypyrrole substrates obtained by two different techniques: Electrospun nanofibres and extruded microfibres es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ijbiomac.2020.09.181 es_ES
dc.rights.accessRights Embargado es_ES
dc.date.embargoEndDate 2021-11-15 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Gisbert-Roca, F.; Más Estellés, J.; Monleón Pradas, M.; Martínez-Ramos, C. (2020). Axonal extension from dorsal root ganglia on fibrillar and highly aligned poly(lactic acid)-polypyrrole substrates obtained by two different techniques: Electrospun nanofibres and extruded microfibres. International Journal of Biological Macromolecules. 163:1959-1969. https://doi.org/10.1016/j.ijbiomac.2020.09.181 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.ijbiomac.2020.09.181 es_ES
dc.description.upvformatpinicio 1959 es_ES
dc.description.upvformatpfin 1969 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 163 es_ES
dc.identifier.pmid 32979445 es_ES
dc.relation.pasarela S\418652 es_ES
dc.contributor.funder Ministerio de Educación es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES


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