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Temperature and ph responsive behaviour of antifouling zwitterionic mesoporous silica nanoparticles.

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Temperature and ph responsive behaviour of antifouling zwitterionic mesoporous silica nanoparticles.

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dc.contributor.author Beltran-Osuna, Angela A. es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Perilla, Jairo E. es_ES
dc.date.accessioned 2021-04-28T03:31:54Z
dc.date.available 2021-04-28T03:31:54Z
dc.date.issued 2020-04-07 es_ES
dc.identifier.issn 0021-8979 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165719
dc.description.abstract [EN] Zwitterionic brush grafting is considered a serious strategy for surface modification on mesoporous silica nanoparticles (MSN) and a prominent alternative to polyethylene glycol films for antifouling applications. In this study, the solution behavior of poly(sulfobetaine methacrylate) (pSBMA) polymer brushes grafted on MSN (95 +/- 15nm particle diameter, 2.8nm pore size) was evaluated. The layers increased their hydrodynamic diameter (d(H)) with increasing temperature, indicating a conformational change from a surface-collapsed state to a fully solvated brush. This development was marked by a transition temperature, related to the molecular weight and the theoretical length of the polymer chains. Variation of d(H) with pH values was studied and a zwitterionic range of 5-9 was established where the electric charges in the molecule were balanced. Zeta potential (ZP) values for all pSBMA-MSN products were also measured. A decreasing trend of ZP with pH and an isoelectric point around 5.5-6.5 was obtained for all dispersions. Furthermore, the influence of temperature was analyzed on ZP and a directly proportional correlation was found, with increasing rates of 0.50-0.87%/degrees C. Finally, ZP variation with electrolyte concentration was determined and a range of 40-60mM of NaCl concentration was established to reach an almost zero-charge point for all nanoparticles. It was demonstrated that the solution response of pSBMA-MSN can be modulated by temperature, pH, and ionic concentration of the media. These behaviors could be used as controlled release mechanisms for the application of pSBMA-MSN as carriers in biomedicine and nanophamaceutical fields in the future. Published under license by AIP Publishing. es_ES
dc.description.sponsorship Jose L. Gomez Ribelles acknowledges support of the Ministerio de Economia y Competitividad, MINECO (Research No. MAT2016-76039-C4-1-R). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions, and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work was also supported by Ministerio de Ciencia, Tecnologia e Innovacion (MINCIENCIAS), Convocatoria 567 Doctorados Nacionales, and Universidad Nacional de Colombia (Grant No. DIB 201010021438). The authors acknowledge the effort of Ramon Martinez Manez, Scientific Director of the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and Head of the Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) at Universitat Politecnica de Valencia, where all measurements were performed es_ES
dc.language Inglés es_ES
dc.publisher American Institute of Physics es_ES
dc.relation.ispartof Journal of Applied Physics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Temperature and ph responsive behaviour of antifouling zwitterionic mesoporous silica nanoparticles. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1063/1.5140707 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UNAL//DIB 201010021438/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Beltran-Osuna, AA.; Gómez Ribelles, JL.; Perilla, JE. (2020). Temperature and ph responsive behaviour of antifouling zwitterionic mesoporous silica nanoparticles. Journal of Applied Physics. 127(13):135106-1-135106-11. https://doi.org/10.1063/1.5140707 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1063/1.5140707 es_ES
dc.description.upvformatpinicio 135106-1 es_ES
dc.description.upvformatpfin 135106-11 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 127 es_ES
dc.description.issue 13 es_ES
dc.relation.pasarela S\433275 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Universidad Nacional de Colombia es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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dc.subject.ods 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades es_ES


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