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dc.contributor.author | Beltran-Osuna, Angela A. | es_ES |
dc.contributor.author | Gómez Ribelles, José Luís | es_ES |
dc.contributor.author | Perilla, Jairo E. | es_ES |
dc.date.accessioned | 2021-04-28T03:31:54Z | |
dc.date.available | 2021-04-28T03:31:54Z | |
dc.date.issued | 2020-04-07 | es_ES |
dc.identifier.issn | 0021-8979 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/165719 | |
dc.description.abstract | [EN] Zwitterionic brush grafting is considered a serious strategy for surface modification on mesoporous silica nanoparticles (MSN) and a prominent alternative to polyethylene glycol films for antifouling applications. In this study, the solution behavior of poly(sulfobetaine methacrylate) (pSBMA) polymer brushes grafted on MSN (95 +/- 15nm particle diameter, 2.8nm pore size) was evaluated. The layers increased their hydrodynamic diameter (d(H)) with increasing temperature, indicating a conformational change from a surface-collapsed state to a fully solvated brush. This development was marked by a transition temperature, related to the molecular weight and the theoretical length of the polymer chains. Variation of d(H) with pH values was studied and a zwitterionic range of 5-9 was established where the electric charges in the molecule were balanced. Zeta potential (ZP) values for all pSBMA-MSN products were also measured. A decreasing trend of ZP with pH and an isoelectric point around 5.5-6.5 was obtained for all dispersions. Furthermore, the influence of temperature was analyzed on ZP and a directly proportional correlation was found, with increasing rates of 0.50-0.87%/degrees C. Finally, ZP variation with electrolyte concentration was determined and a range of 40-60mM of NaCl concentration was established to reach an almost zero-charge point for all nanoparticles. It was demonstrated that the solution response of pSBMA-MSN can be modulated by temperature, pH, and ionic concentration of the media. These behaviors could be used as controlled release mechanisms for the application of pSBMA-MSN as carriers in biomedicine and nanophamaceutical fields in the future. Published under license by AIP Publishing. | es_ES |
dc.description.sponsorship | Jose L. Gomez Ribelles acknowledges support of the Ministerio de Economia y Competitividad, MINECO (Research No. MAT2016-76039-C4-1-R). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions, and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work was also supported by Ministerio de Ciencia, Tecnologia e Innovacion (MINCIENCIAS), Convocatoria 567 Doctorados Nacionales, and Universidad Nacional de Colombia (Grant No. DIB 201010021438). The authors acknowledge the effort of Ramon Martinez Manez, Scientific Director of the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and Head of the Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) at Universitat Politecnica de Valencia, where all measurements were performed | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Institute of Physics | es_ES |
dc.relation.ispartof | Journal of Applied Physics | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Temperature and ph responsive behaviour of antifouling zwitterionic mesoporous silica nanoparticles. | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1063/1.5140707 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UNAL//DIB 201010021438/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Beltran-Osuna, AA.; Gómez Ribelles, JL.; Perilla, JE. (2020). Temperature and ph responsive behaviour of antifouling zwitterionic mesoporous silica nanoparticles. Journal of Applied Physics. 127(13):135106-1-135106-11. https://doi.org/10.1063/1.5140707 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1063/1.5140707 | es_ES |
dc.description.upvformatpinicio | 135106-1 | es_ES |
dc.description.upvformatpfin | 135106-11 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 127 | es_ES |
dc.description.issue | 13 | es_ES |
dc.relation.pasarela | S\433275 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Universidad Nacional de Colombia | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
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dc.subject.ods | 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades | es_ES |