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A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model

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A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model

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dc.contributor.author Viezzer, Christian es_ES
dc.contributor.author Mazzuca, Rafael es_ES
dc.contributor.author Machado, Denise Cantarelli es_ES
dc.contributor.author Forte, María Magdalena de Camargo es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2021-04-29T03:31:55Z
dc.date.available 2021-04-29T03:31:55Z
dc.date.issued 2020-03-01 es_ES
dc.identifier.issn 0144-8617 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165763
dc.description.abstract [EN] Foot ulcers, a common complication of diabetes, can cause physical incapacity and are derived from several factors, including poor wound healing. New therapeutic strategies are needed to minimize this complication for the sake of patients' health. We therefore developed a new chitosan- polyurethane hydrogel membrane (HPUC) and the WA results confirmed that HPUC present low cytotoxicity and improved wound healing when used with mononuclear bone marrow fraction cells in the diabetic rat model. The biodegradable hydrogels were produced in block copolymer networks with a combination of chitosan blocks and biodegradable polyurethane. The membranes were characterized by FTIR, C-13-NMR and thermogravimetry. Swelling and hydrolytic degradation were also evaluated. The non-solubility of the membranes in good solvents and the chemical characterization confirmed that the network structure was formed between the PU and the chitosan through urea/urethane bonds. The findings confirm that the HPUC have interesting properties that make them suitable for wound healing applications. es_ES
dc.description.sponsorship This work was funded by: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -doctoral fellowships to Viezzer, C (CAPES/PDSE-BEX: 1408/11-9) and the Spanish Ministry of Economy and Competitiveness (MINECO) through the MAT2016-76039-C4-1-R Project, including FEDER financial support. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Carbohydrate Polymers es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Chitosan es_ES
dc.subject Waterborne polyurethane es_ES
dc.subject Wound healing es_ES
dc.subject Stem cell therapy es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.carbpol.2019.115734 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CAPES//BEX 1408%2F11-9/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Viezzer, C.; Mazzuca, R.; Machado, DC.; Forte, MMDC.; Gómez Ribelles, JL. (2020). A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model. Carbohydrate Polymers. 231:1-10. https://doi.org/10.1016/j.carbpol.2019.115734 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.carbpol.2019.115734 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 231 es_ES
dc.identifier.pmid 31888801 es_ES
dc.relation.pasarela S\433255 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior, Brasil es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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dc.subject.ods 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades es_ES


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