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Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies

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Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies

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Vayá Pérez, I.; Andreu Ros, MI.; Lence, E.; González-Bello, C.; Cuquerella Alabort, MC.; Navarrete-Miguel, M.; Roca-Sanjuán, D.... (2020). Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies. Chemistry - A European Journal. 26(68):15922-15930. https://doi.org/10.1002/chem.202001336

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Title: Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies
Author: Vayá Pérez, Ignacio Andreu Ros, María Inmaculada Lence, Emilio González-Bello, Concepción Cuquerella Alabort, Maria Consuelo Navarrete-Miguel, Miriam Roca-Sanjuán, Daniel Miranda Alonso, Miguel Ángel
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Abstract:
[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...[+]
Subjects: Anticancer drugs , Femtosecond transient absorption , Fluorescence , Lapatinib , Molecular dynamics simulations
Copyrigths: Reserva de todos los derechos
Source:
Chemistry - A European Journal. (issn: 0947-6539 )
DOI: 10.1002/chem.202001336
Publisher:
John Wiley & Sons
Publisher version: https://doi.org/10.1002/chem.202001336
Project ID:
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87054-C2-2-P/ES/FOTOFISICA DE SISTEMAS ORGANICOS DE TRANSFERENCIA DE CARGA INNOVADORES/
ISCIII/RD16/0006/0004
...[+]
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87054-C2-2-P/ES/FOTOFISICA DE SISTEMAS ORGANICOS DE TRANSFERENCIA DE CARGA INNOVADORES/
info:eu-repo/grantAgreement/MINECO//SAF2016-75638-R/ES/DESARROLLO DE NUEVOS FARMACOS PARA EL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS MULTIRESISTENTES: APROXIMACIONES QUE INCIDEN SOBRE VIABILIDAD, RESISTENCIA Y VIRULENCIA/
info:eu-repo/grantAgreement/MINECO//MDM-2015-0538/ES/INSTITUTO DE CIENCIA MOLECULAR/
info:eu-repo/grantAgreement/MINECO//RYC-2015-19234/ES/RYC-2015-19234/
info:eu-repo/grantAgreement/Xunta de Galicia//ED431B 2018%2F04/
info:eu-repo/grantAgreement/ISCIII//CP1116%2F00052/
info:eu-repo/grantAgreement/Xunta de Galicia//ED431G 2019%2F03/
info:eu-repo/grantAgreement/MINECO//PI16%2F01877/ES/Estrategia integrada de fotodiagnóstico combinando evaluación clínica, ensayos biológicos y estudios mecanísticos/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F075/ES/Reacciones fotoquímicas de biomoléculas/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-89416-R/ES/FUNCIONALIZACION DE NANOPARTICULAS DE ORO CON MARCADORES BIOLOGICOS Y SENSIBILIZADORES DE OXIGENO SINGLETE PARA SU USO EN BIOMEDICINA/
ISCIII/RD16/0006/0004
MINISTERIO DE ECONOMIA Y EMPRESA/RYC-2015-17737
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Description: This is the peer reviewed version of the following article: I. Vayá, I. Andreu, E. Lence, C. González-Bello, M. Consuelo Cuquerella, M. Navarrete-Miguel, D. Roca-Sanjuán, M. A. Miranda, Chem. Eur. J. 2020, 26, 15922, which has been published in final form at https://doi.org/10.1002/chem.202001336. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Thanks:
Financial support from the Spanish Government (RYC-2015-17737, CTQ2017-89416-R, ISCIII grants RD16/0006/0004, PI16/01877 and CPII16/00052, SAF2016-75638-R, RYC-2015-19234, CTQ2017-87054-C2-2-P, and MDM-2015-0538), Conselleria ...[+]
Type: Artículo

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