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Ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits

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Ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits

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dc.contributor.author Serna-García, Marta es_ES
dc.contributor.author Peiró Barber, Rosa Mª es_ES
dc.contributor.author Serna, Eva es_ES
dc.contributor.author Santacreu Jerez, María Antonia es_ES
dc.date.accessioned 2021-06-01T03:32:18Z
dc.date.available 2021-06-01T03:32:18Z
dc.date.issued 2020-10 es_ES
dc.identifier.uri http://hdl.handle.net/10251/167008
dc.description.abstract [EN] Transcriptomic analysis showed nineteen potential biomarkers in ovarian tissue from females belonged to a rabbit line selected for ovulation rate for 10 generations and the control line. These females differed not only in ovulation rate but also in prenatal survival since similar litter size were observed. Litter size is an essential trait in rabbit meat production but with low heritability. A selection experiment for ovulation rate has been performed for 10 generations to improve litter size in rabbits. The selected line increased two ova more than the control line but nevertheless a negative correlation was observed with prenatal survival. A transcriptomic study was performed, using microarrays, in ovarian tissue from females belonging to the selected line and the control line. Our results showed 1357 differential expressed genes and nineteen potential biomarkers associated with prenatal mortality, which could explain differences between litter size in rabbits. Cell death was the most relevant process. es_ES
dc.description.sponsorship This research was supported by MEC (AGL2014-55921-C2-1-P) and Generalitat Valenciana (Prometeo 2009/125). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Animals es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Ovulation rate es_ES
dc.subject Litter size es_ES
dc.subject Transcriptomic analysis es_ES
dc.subject Rabbit es_ES
dc.subject Ovarian tissue es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.subject.classification GENETICA es_ES
dc.title Ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/ani10101924 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2014-55921-C2-1-P/ES/ESTUDIO GENOMICO Y METABOLOMICO DE VARIAS LINEAS DE SELECCION DIVERGENTE EN CONEJO: EL CONEJO COMO MODELO EXPERIMENTAL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F125/ES/Efecto de la crioconservación de embriones sobre el desarrollo y el re-establecimiento de poblaciones/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Serna-García, M.; Peiró Barber, RM.; Serna, E.; Santacreu Jerez, MA. (2020). Ovarian transcriptomic analysis reveals differential expression genes associated with cell death process after selection for ovulation rate in rabbits. Animals. 10(10):1-11. https://doi.org/10.3390/ani10101924 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/ani10101924 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 11 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 10 es_ES
dc.identifier.eissn 2076-2615 es_ES
dc.identifier.pmid 33092110 es_ES
dc.identifier.pmcid PMC7593938 es_ES
dc.relation.pasarela S\433497 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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