Mostrar el registro sencillo del ítem
dc.contributor.author | Oliver-Gil, Sandra | es_ES |
dc.contributor.author | Moliner, L. | es_ES |
dc.contributor.author | Ilisie, V. | es_ES |
dc.contributor.author | Benlloch Baviera, Jose María | es_ES |
dc.contributor.author | Rodríguez-Álvarez, M.J. | es_ES |
dc.date.accessioned | 2021-06-29T03:31:32Z | |
dc.date.available | 2021-06-29T03:31:32Z | |
dc.date.issued | 2020-03 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/168486 | |
dc.description.abstract | [EN] The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries. | es_ES |
dc.description.sponsorship | This project has been co-financed by the Spanish Government Grants TEC2016-79884-C2 and RTC-2016-5186-1, by the European Union through the European Regional Development Fund (ERDF) and by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (Grant Agreement No. 695536). The work of V.I. was supported by the Generalitat Valenciana APOSTD/2019/086 fellowship. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | Sensors | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Positron Emission Tomography (PET) | es_ES |
dc.subject | PET imaging | es_ES |
dc.subject | Dedicated cardiac system | es_ES |
dc.subject.classification | MATEMATICA APLICADA | es_ES |
dc.title | Simulation Study for Designing a Dedicated Cardiac TOF-PET System | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/s20051311 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/695536/EU/Innovative PET scanner for dynamic imaging/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//APOSTD%2F2019%2F086/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2016-79884-C2-2-R/ES/DESARROLLO DEL SOFTWARE PARA SISTEMA DE DIAGNOSTICO POR IMAGEN MOLECULAR PARA CORAZON EN CONDICIONES DE STRESS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RTC-2016-5186-1/ES/Control objetivo del deterioro cognitivo mediante análisis de imagen de amiloide/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada | es_ES |
dc.description.bibliographicCitation | Oliver-Gil, S.; Moliner, L.; Ilisie, V.; Benlloch Baviera, JM.; Rodríguez-Álvarez, M. (2020). Simulation Study for Designing a Dedicated Cardiac TOF-PET System. Sensors. 20(5):1-16. https://doi.org/10.3390/s20051311 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/s20051311 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 16 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 20 | es_ES |
dc.description.issue | 5 | es_ES |
dc.identifier.eissn | 1424-8220 | es_ES |
dc.identifier.pmid | 32121227 | es_ES |
dc.identifier.pmcid | PMC7085583 | es_ES |
dc.relation.pasarela | S\404525 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
dc.description.references | Gaemperli, O., & Kaufmann, P. A. (2011). PET and PET/CT in cardiovascular disease. Annals of the New York Academy of Sciences, 1228(1), 109-136. doi:10.1111/j.1749-6632.2011.06030.x | es_ES |
dc.description.references | Thackeray, J. T., & Bengel, F. M. (2018). Molecular Imaging of Myocardial Inflammation With Positron Emission Tomography Post-Ischemia. JACC: Cardiovascular Imaging, 11(9), 1340-1355. doi:10.1016/j.jcmg.2018.05.026 | es_ES |
dc.description.references | Li, Z., Gupte, A. A., Zhang, A., & Hamilton, D. J. (2017). Pet Imaging and its Application in Cardiovascular Diseases. Methodist DeBakey Cardiovascular Journal, 13(1), 29. doi:10.14797/mdcj-13-1-29 | es_ES |
dc.description.references | Juárez-Orozco, L. E., Tio, R. A., Alexanderson, E., Dweck, M., Vliegenthart, R., El Moumni, M., … Slart, R. H. J. A. (2017). Quantitative myocardial perfusion evaluation with positron emission tomography and the risk of cardiovascular events in patients with coronary artery disease: a systematic review of prognostic studies. European Heart Journal - Cardiovascular Imaging, 19(10), 1179-1187. doi:10.1093/ehjci/jex331 | es_ES |
dc.description.references | Schelbert, H. R. (2009). Quantification of Myocardial Blood Flow: What is the Clinical Role? Cardiology Clinics, 27(2), 277-289. doi:10.1016/j.ccl.2008.12.009 | es_ES |
dc.description.references | Knuuti, J., Kajander, S., Mäki, M., & Ukkonen, H. (2009). Quantification of myocardial blood flow will reform the detection of CAD. Journal of Nuclear Cardiology, 16(4), 497-506. doi:10.1007/s12350-009-9101-1 | es_ES |
dc.description.references | Peng, H. (2015). Design study of a cardiac-dedicated PET system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 779, 39-46. doi:10.1016/j.nima.2015.01.042 | es_ES |
dc.description.references | Gonzalez, A. J., Sanchez, F., & Benlloch, J. M. (2018). Organ-Dedicated Molecular Imaging Systems. IEEE Transactions on Radiation and Plasma Medical Sciences, 2(5), 388-403. doi:10.1109/trpms.2018.2846745 | es_ES |
dc.description.references | Moliner, L., Rodríguez-Alvarez, M. J., Catret, J. V., González, A., Ilisie, V., & Benlloch, J. M. (2019). NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems. Scientific Reports, 9(1). doi:10.1038/s41598-019-51898-z | es_ES |
dc.description.references | Ahmed, A. M., Tashima, H., Yoshida, E., Nishikido, F., & Yamaya, T. (2017). Simulation study comparing the helmet-chin PET with a cylindrical PET of the same number of detectors. Physics in Medicine and Biology, 62(11), 4541-4550. doi:10.1088/1361-6560/aa685c | es_ES |
dc.description.references | Cho, Z.-H., Son, Y.-D., Kim, H.-K., Kwon, D.-H., Joo, Y.-H., Ra, J. B., … Kim, Y.-B. (2019). Development of Positron Emission Tomography With Wobbling and Zooming for High Sensitivity and High-Resolution Molecular Imaging. IEEE Transactions on Medical Imaging, 38(12), 2875-2882. doi:10.1109/tmi.2019.2916326 | es_ES |
dc.description.references | Surti, S., & Karp, J. S. (2008). Design considerations for a limited angle, dedicated breast, TOF PET scanner. Physics in Medicine and Biology, 53(11), 2911-2921. doi:10.1088/0031-9155/53/11/010 | es_ES |
dc.description.references | Surti, S., & Karp, J. S. (2016). Advances in time-of-flight PET. Physica Medica, 32(1), 12-22. doi:10.1016/j.ejmp.2015.12.007 | es_ES |
dc.description.references | Grant, A. M., Deller, T. W., Khalighi, M. M., Maramraju, S. H., Delso, G., & Levin, C. S. (2016). NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system. Medical Physics, 43(5), 2334-2343. doi:10.1118/1.4945416 | es_ES |
dc.description.references | Van Sluis, J., de Jong, J., Schaar, J., Noordzij, W., van Snick, P., Dierckx, R., … Boellaard, R. (2019). Performance Characteristics of the Digital Biograph Vision PET/CT System. Journal of Nuclear Medicine, 60(7), 1031-1036. doi:10.2967/jnumed.118.215418 | es_ES |
dc.description.references | Ito, M., Lee, M. S., & Lee, J. S. (2013). Continuous depth-of-interaction measurement in a single-layer pixelated crystal array using a single-ended readout. Physics in Medicine and Biology, 58(5), 1269-1282. doi:10.1088/0031-9155/58/5/1269 | es_ES |
dc.description.references | Bugalho, R., Di Francesco, A., Ferramacho, L., Leong, C., Niknejad, T., Oliveira, L., … Varela, J. (2018). Experimental results with TOFPET2 ASIC for time-of-flight applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 195-198. doi:10.1016/j.nima.2017.11.034 | es_ES |
dc.description.references | Gundacker, S., Auffray, E., Frisch, B., Jarron, P., Knapitsch, A., Meyer, T., … Lecoq, P. (2013). Time of flight positron emission tomography towards 100ps resolution with L(Y)SO: an experimental and theoretical analysis. Journal of Instrumentation, 8(07), P07014-P07014. doi:10.1088/1748-0221/8/07/p07014 | es_ES |
dc.description.references | A Code System for Monte Carlo Simulation of Electron and Photon Transporthttp://www.oecd-nea.org/lists/penelope.html | es_ES |
dc.description.references | Strydhorst, J., & Buvat, I. (2016). Redesign of the GATE PET coincidence sorter. Physics in Medicine and Biology, 61(18), N522-N531. doi:10.1088/0031-9155/61/18/n522 | es_ES |
dc.description.references | Baró, J., Sempau, J., Fernández-Varea, J. M., & Salvat, F. (1995). PENELOPE: An algorithm for Monte Carlo simulation of the penetration and energy loss of electrons and positrons in matter. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 100(1), 31-46. doi:10.1016/0168-583x(95)00349-5 | es_ES |
dc.description.references | Sempau, J., Acosta, E., Baro, J., Fernández-Varea, J. M., & Salvat, F. (1997). An algorithm for Monte Carlo simulation of coupled electron-photon transport. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 132(3), 377-390. doi:10.1016/s0168-583x(97)00414-x | es_ES |
dc.description.references | Sempau, J., Fernández-Varea, J. M., Acosta, E., & Salvat, F. (2003). Experimental benchmarks of the Monte Carlo code penelope. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 207(2), 107-123. doi:10.1016/s0168-583x(03)00453-1 | es_ES |
dc.description.references | Reader, A. J., Ally, S., Bakatselos, F., Manavaki, R., Walledge, R. J., Jeavons, A. P., … Zweit, J. (2002). One-pass list-mode EM algorithm for high-resolution 3-D PET image reconstruction into large arrays. IEEE Transactions on Nuclear Science, 49(3), 693-699. doi:10.1109/tns.2002.1039550 | es_ES |
dc.description.references | Spanoudaki, V. C., & Levin, C. S. (2010). Photo-Detectors for Time of Flight Positron Emission Tomography (ToF-PET). Sensors, 10(11), 10484-10505. doi:10.3390/s101110484 | es_ES |
dc.description.references | Siddon, R. L. (1985). Fast calculation of the exact radiological path for a three-dimensional CT array. Medical Physics, 12(2), 252-255. doi:10.1118/1.595715 | es_ES |
dc.description.references | Vandenberghe, S., Daube-Witherspoon, M. E., Lewitt, R. M., & Karp, J. S. (2006). Fast reconstruction of 3D time-of-flight PET data by axial rebinning and transverse mashing. Physics in Medicine and Biology, 51(6), 1603-1621. doi:10.1088/0031-9155/51/6/017 | es_ES |
dc.description.references | Performance Measurements of Positron Emission Tomographshttps://www.nema.org/Standards/ComplimentaryDocuments/Contents%20and%20Scope%20NEMA%20NU%202%202012.pdf | es_ES |
dc.description.references | Yu, W., & Zeng, L. (2014). A Novel Weighted Total Difference Based Image Reconstruction Algorithm for Few-View Computed Tomography. PLoS ONE, 9(10), e109345. doi:10.1371/journal.pone.0109345 | es_ES |
dc.description.references | Tashima, H., Yamaya, T., Yoshida, E., Kinouchi, S., Watanabe, M., & Tanaka, E. (2012). A single-ring OpenPET enabling PET imaging during radiotherapy. Physics in Medicine and Biology, 57(14), 4705-4718. doi:10.1088/0031-9155/57/14/4705 | es_ES |
dc.description.references | Yamaya, T., Inaniwa, T., Minohara, S., Yoshida, E., Inadama, N., Nishikido, F., … Murayama, H. (2008). A proposal of an open PET geometry. Physics in Medicine and Biology, 53(3), 757-773. doi:10.1088/0031-9155/53/3/015 | es_ES |
dc.description.references | Miyake, K. K., Matsumoto, K., Inoue, M., Nakamoto, Y., Kanao, S., Oishi, T., … Togashi, K. (2014). Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards. Journal of Nuclear Medicine, 55(7), 1198-1203. doi:10.2967/jnumed.113.131565 | es_ES |
dc.description.references | Yamamoto, S., Honda, M., Oohashi, T., Shimizu, K., & Senda, M. (2011). Development of a Brain PET System, PET-Hat: A Wearable PET System for Brain Research. IEEE Transactions on Nuclear Science, 58(3), 668-673. doi:10.1109/tns.2011.2105502 | es_ES |
dc.description.references | Garibaldi, F., Capuani, S., Colilli, S., Cosentino, L., Cusanno, F., Leo, R. D., … Tamma, C. (2013). TOPEM: A PET-TOF endorectal probe, compatible with MRI for diagnosis and follow up of prostate cancer. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 702, 13-15. doi:10.1016/j.nima.2012.09.020 | es_ES |
dc.description.references | González-Montoro, A., Sánchez, F., Martí, R., Hernández, L., Aguilar, A., Barberá, J., … González, A. J. (2018). Detector block performance based on a monolithic LYSO crystal using a novel signal multiplexing method. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 372-377. doi:10.1016/j.nima.2017.10.098 | es_ES |