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Production of chiral alcohols from racemic mixtures by integrated heterogeneous chemoenzymatic catalysis in fixed bed continuous operation

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Production of chiral alcohols from racemic mixtures by integrated heterogeneous chemoenzymatic catalysis in fixed bed continuous operation

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dc.contributor.author Carceller-Carceller, Jose Miguel es_ES
dc.contributor.author Mifsud, Maria es_ES
dc.contributor.author Climent Olmedo, María José es_ES
dc.contributor.author Iborra Chornet, Sara es_ES
dc.contributor.author Corma Canós, Avelino es_ES
dc.date.accessioned 2021-07-01T03:33:03Z
dc.date.available 2021-07-01T03:33:03Z
dc.date.issued 2020-05-07 es_ES
dc.identifier.issn 1463-9262 es_ES
dc.identifier.uri http://hdl.handle.net/10251/168620
dc.description.abstract [EN] Valuable chiral alcs. have been obtained from racemic mixts. with an integrated heterogeneous chemoenzymic catalyst in a two consecutive fixed catalytic bed continuous reactor system. In the first bed the racemic mixt. of alcs. is oxidized to the prochiral ketone with a Zr-Beta zeolite and using acetone as the hydrogen acceptor. In the second catalytic bed the prochiral ketone is stereoselectively reduced with an alc. dehydrogenase (ADH) immobilized on a two dimensional (2D) zeolite. In this process, the alc. (isopropanol) formed by the redn. of acetone in the first step reduces the cofactor in the second step, and the full reaction cycle is in this way internally closed with 100% atom economy. A conversion of about 95% with ~100% selectivity to either the (R) or the (S) alc. has been obtained for a variety of racemic mixts. of alcs es_ES
dc.description.sponsorship The research leading to these results has received funding from the Spanish Ministry of Science, Innovation and Universities through "Severo Ochoa" Excellence Programme (SEV-2016-0683) and the PGC2018-097277-B-100(MCIU/AEI/FEDER, UE) project. J. M. C. thanks to Universitat Politecnica de Valencia for a predoctoral fellowship. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Green Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Production of chiral alcohols from racemic mixtures by integrated heterogeneous chemoenzymatic catalysis in fixed bed continuous operation es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c9gc04127c es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-097277-B-I00/ES/MEJORA DEL CONCEPTO DE BIORREFINERIA MEDIANTE IMPLEMENTACION DE NUEVOS PROCESOS CATALITICOS CON CATALIZADORES SOLIDOS DE METALES NO NOBLES PARA LA PRODUCCION DE BIOCOMPUESTOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2016-0683/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Carceller-Carceller, JM.; Mifsud, M.; Climent Olmedo, MJ.; Iborra Chornet, S.; Corma Canós, A. (2020). Production of chiral alcohols from racemic mixtures by integrated heterogeneous chemoenzymatic catalysis in fixed bed continuous operation. Green Chemistry. 22(9):2767-2777. https://doi.org/10.1039/c9gc04127c es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c9gc04127c es_ES
dc.description.upvformatpinicio 2767 es_ES
dc.description.upvformatpfin 2777 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 22 es_ES
dc.description.issue 9 es_ES
dc.relation.pasarela S\433083 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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