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Maternal Transmission Ratio Distortion in two Iberian pig varieties

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Maternal Transmission Ratio Distortion in two Iberian pig varieties

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dc.contributor.author Vazquez-Gomez, Marta es_ES
dc.contributor.author Martín de Hijas-Villalba, Melani es_ES
dc.contributor.author Varona, Luis es_ES
dc.contributor.author Ibáñez-Escriche, Noelia es_ES
dc.contributor.author Rosas, Juan Pablo es_ES
dc.contributor.author Negro, Sara es_ES
dc.contributor.author Noguera, Jose Luis es_ES
dc.contributor.author Casellas, Joaquim es_ES
dc.date.accessioned 2021-07-08T03:31:35Z
dc.date.available 2021-07-08T03:31:35Z
dc.date.issued 2020-09 es_ES
dc.identifier.uri http://hdl.handle.net/10251/168946
dc.description.abstract [EN] Transmission ratio distortion (TRD) is defined as the allele transmission deviation from the heterozygous parent to the offspring from the expected Mendelian genotypic frequencies. Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. Genotypes from a total of 247 families (dam and offspring) of Entrepelado (n = 129) and Retinto (n = 118) Iberian varieties were analyzed. The offspring were sired by both ungenotyped purebred Retinto and Entrepelado Iberian boars, regardless of the dam variety used. After quality control, 16,246 single-nucleotide polymorphisms (SNPs) in the Entrepelado variety and 9744 SNPs in the Retinto variety were analyzed. Maternal TRD was evaluated by a likelihood ratio test under SNP-by-SNP, adapting a previous model solved by Bayesian inference. Results provided 68 maternal TRD loci (TRDLs) in the Entrepelado variety and 24 in the Retinto variety (q < 0.05), with mostly negative TRD values, increasing the transmission of the minor allele. In addition, both varieties shared ten common TRDLs. No strong evidence of biological effects was found in genes with TRDLs. However, some biological processes could be affected by TRDLs, such as embryogenesis at different levels and lipid metabolism. These findings could provide useful insight into the genetic mechanisms to improve the swine industry, particularly in traditional breeds. es_ES
dc.description.sponsorship The Spanish Government funded this research, grants number CGL2016-80155-R, and IDI-20170304 es_ES
dc.language Inglés es_ES
dc.publisher MDPI es_ES
dc.relation.ispartof Genes es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Sus scrofa es_ES
dc.subject Genome scan es_ES
dc.subject Maximum likelihood es_ES
dc.subject Segregation distortion es_ES
dc.subject Ungenotyped parents es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Maternal Transmission Ratio Distortion in two Iberian pig varieties es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/genes11091050 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CGL2016-80155-R/ES/ANALISIS ¿OMICO¿ DE CARACTERES REPRODUCTIVOS EN UN CRUCE DIAELICO ENTRE TRES ESTIRPES DE CERDO IBERICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MCIU//IDI-20170304/ES/Mejora de la eficiencia productiva y de la calidad de la carne en el programa piramidal de mejora genética de ibérico 'Castúa/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Vazquez-Gomez, M.; Martín De Hijas-Villalba, M.; Varona, L.; Ibáñez-Escriche, N.; Rosas, JP.; Negro, S.; Noguera, JL.... (2020). Maternal Transmission Ratio Distortion in two Iberian pig varieties. Genes. 11(9):1-18. https://doi.org/10.3390/genes11091050 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/genes11091050 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 18 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 9 es_ES
dc.identifier.eissn 2073-4425 es_ES
dc.identifier.pmid 32899475 es_ES
dc.identifier.pmcid PMC7563664 es_ES
dc.relation.pasarela S\418105 es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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