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Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell

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Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell

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dc.contributor.author Pascual-Ahuir Giner, María Desamparados es_ES
dc.contributor.author Fita-Torró, Josep es_ES
dc.contributor.author Proft, Markus Hans es_ES
dc.date.accessioned 2021-07-17T03:34:42Z
dc.date.available 2021-07-17T03:34:42Z
dc.date.issued 2020-11 es_ES
dc.identifier.uri http://hdl.handle.net/10251/169418
dc.description.abstract [EN] The regulation of gene expression is a fundamental process enabling cells to respond to internal and external stimuli or to execute developmental programs. Changes in gene expression are highly dynamic and depend on many intrinsic and extrinsic factors. In this review, we highlight the dynamic nature of transient gene expression changes to better understand cell physiology and development in general. We will start by comparing recent in vivo procedures to capture gene expression in real time. Intrinsic factors modulating gene expression dynamics will then be discussed, focusing on chromatin modifications. Furthermore, we will dissect how cell physiology or age impacts on dynamic gene regulation and especially discuss molecular insights into acquired transcriptional memory. Finally, this review will give an update on the mechanisms of heterogeneous gene expression among genetically identical individual cells. We will mainly focus on state-of-the-art developments in the yeast model but also cover higher eukaryotic systems. es_ES
dc.description.sponsorship This work was funded by Ministerio de Ciencia, Innovacion y Universidades, grant number BFU2016-75792-R. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof International Journal of Molecular Sciences es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Gene expression es_ES
dc.subject Transcriptional activation es_ES
dc.subject Transcriptional memory es_ES
dc.subject Single-cell variability es_ES
dc.subject Reporter assays es_ES
dc.subject Stress adaptation es_ES
dc.subject Transcriptional dynamics es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/ijms21218278 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2016-75792-R/ES/ADAPTACION COORDINADA A ESTRES MEDIANTE LA MODULACION DE LA HOMEOSTASIS MITOCONDRIAL Y LA ACTIVACION SELECTIVA DEL TRANSPORTE MULTI-DROGA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Pascual-Ahuir Giner, MD.; Fita-Torró, J.; Proft, MH. (2020). Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell. International Journal of Molecular Sciences. 21(21):1-19. https://doi.org/10.3390/ijms21218278 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/ijms21218278 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 19 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 21 es_ES
dc.identifier.eissn 1422-0067 es_ES
dc.identifier.pmid 33167354 es_ES
dc.identifier.pmcid PMC7663833 es_ES
dc.relation.pasarela S\424208 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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