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Reversed phase liquid chromatography for the enantioseparation of local anaesthetics in polysaccharide-based stationary phases. Application to biodegradability studies

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Reversed phase liquid chromatography for the enantioseparation of local anaesthetics in polysaccharide-based stationary phases. Application to biodegradability studies

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dc.contributor.author Perez-Baeza, Mireia es_ES
dc.contributor.author Escuder-Gilabert, Laura es_ES
dc.contributor.author Martín-Biosca, Yolanda es_ES
dc.contributor.author Sagrado Vives, Salvador es_ES
dc.contributor.author Medina-Hernández, María José es_ES
dc.date.accessioned 2021-07-21T03:31:42Z
dc.date.available 2021-07-21T03:31:42Z
dc.date.issued 2020-08-16 es_ES
dc.identifier.issn 0021-9673 es_ES
dc.identifier.uri http://hdl.handle.net/10251/169650
dc.description.abstract [EN] A comprehensive study on the chiral separation of bupivacaine, mepivacaine, prilocaine and propanocaine with eight commercial polysaccharide-based chiral stationary phases (CSPs) in reversed phase conditions compatible with MS detection is performed. Methanol and acetonitrile are used as organic modifiers. Retention and resolution values obtained for each compound in the different CSPs and mobile phases are compared. The polysaccharide-based CSPs tested present different enantioselectivity towards the analytes. From the results, the experimental conditions for determining the enantiomers of bupivacaine, mepivacaine, prilocaine and propanocaine in saline aqueous samples using MS detection are used, for the first time, to perform an enantioselective biodegradability study. (C) 2020 Elsevier B.V. All rights reserved. es_ES
dc.description.sponsorship The authors acknowledge the Spanish Ministerio de Economia y Competitividad (MINECO) and the European Regional Development Fund (ERDF) for the financial support (Project CTQ2015-70904-R, MINECO/FEDER, UE). Mireia Perez Baeza acknowledges to Generalitat Valenciana and European Social Fund for the contribution to the contract ACIF/2019/158 es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Journal of Chromatography A es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Local anaesthetics es_ES
dc.subject Cellulose and amylose-based chiral stationary phases es_ES
dc.subject Reversed phase conditions es_ES
dc.subject Enantioselective biodegradation study es_ES
dc.title Reversed phase liquid chromatography for the enantioseparation of local anaesthetics in polysaccharide-based stationary phases. Application to biodegradability studies es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.chroma.2020.461334 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACIF%2F2019%2F158/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2015-70904-R/ES/ESTUDIO DE LA BIODEGRADACION ENANTIOSELECTIVA DE CONTAMINANTES EMERGENTES QUIRALES. IMPLICACIONES Y RIESGOS PARA LA SALUD Y MEDIO AMBIENTE./ es_ES
dc.rights.accessRights Cerrado es_ES
dc.description.bibliographicCitation Perez-Baeza, M.; Escuder-Gilabert, L.; Martín-Biosca, Y.; Sagrado Vives, S.; Medina-Hernández, MJ. (2020). Reversed phase liquid chromatography for the enantioseparation of local anaesthetics in polysaccharide-based stationary phases. Application to biodegradability studies. Journal of Chromatography A. 1625:1-9. https://doi.org/10.1016/j.chroma.2020.461334 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.chroma.2020.461334 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 9 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 1625 es_ES
dc.identifier.pmid 32709359 es_ES
dc.relation.pasarela S\436559 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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