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Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications

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Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications

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dc.contributor.author Torres, Elena es_ES
dc.contributor.author Domínguez-Candela, Iván es_ES
dc.contributor.author Castelló-Palacios, Sergio es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Fombuena, Vicent es_ES
dc.date.accessioned 2021-09-09T03:35:10Z
dc.date.available 2021-09-09T03:35:10Z
dc.date.issued 2020-08 es_ES
dc.identifier.uri http://hdl.handle.net/10251/171682
dc.description.abstract [EN] We aimed to study the distribution of hydroxyapatite (HA) and halloysite nanotubes (HNTs) as fillers and their influence on the hydrophobic character of conventional polymers used in the biomedical field. The hydrophobic polyester poly (¿-caprolactone) (PCL) was blended with its more hydrophilic counterpart poly (lactic acid) (PLA) and the hydrophilic acrylate poly (2-hydroxyethyl methacrylate) (PHEMA) was analogously compared to poly (ethyl methacrylate) (PEMA) and its copolymer. The addition of HA and HNTs clearly improve surface wettability in neat samples (PCL and PHEMA), but not that of the corresponding binary blends. Energy-dispersive X-ray spectroscopy mapping analyses show a homogenous distribution of HA with appropriate Ca/P ratios between 1.3 and 2, even on samples that were incubated for seven days in simulated body fluid, with the exception of PHEMA, which is excessively hydrophilic to promote the deposition of salts on its surface. HNTs promote large aggregates on more hydrophilic polymers. The degradation process of the biodegradable polyester PCL blended with PLA, and the addition of HA and HNTs, provide hydrophilic units and decrease the overall crystallinity of PCL. Consequently, after 12 weeks of incubation in phosphate buffered saline the mass loss increases up to 48% and mechanical properties decrease above 60% compared with the PCL/PLA blend. es_ES
dc.description.sponsorship Dominguez-Candela thanks the Universitat Politècnica de València for the financial support through an FPI-UPV grant (PAID-01-19) es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Polymers es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Biomedical polymers es_ES
dc.subject Hydroxyapatite es_ES
dc.subject Halloysite es_ES
dc.subject Mechanical properties es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/polym12081703 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-01-19/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Telecomunicación y Aplicaciones Multimedia - Institut Universitari de Telecomunicacions i Aplicacions Multimèdia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear es_ES
dc.description.bibliographicCitation Torres, E.; Domínguez-Candela, I.; Castelló-Palacios, S.; Vallés Lluch, A.; Fombuena, V. (2020). Development and Characterization of Polyester and Acrylate-Based Composites with Hydroxyapatite and Halloysite Nanotubes for Medical Applications. Polymers. 12(8):1-13. https://doi.org/10.3390/polym12081703 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/polym12081703 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 13 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 8 es_ES
dc.identifier.eissn 2073-4360 es_ES
dc.identifier.pmid 32751376 es_ES
dc.identifier.pmcid PMC7465803 es_ES
dc.relation.pasarela S\416489 es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
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