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A possible use of melatonin in the dental field: Protein adsorption and in vitro cell response on coated titanium

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A possible use of melatonin in the dental field: Protein adsorption and in vitro cell response on coated titanium

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dc.contributor.author Cerqueira, Andreia es_ES
dc.contributor.author Romero-Gavilán, Francisco es_ES
dc.contributor.author Araujo-Gomes, Nuno es_ES
dc.contributor.author García-Arnáez, Iñaki es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.contributor.author Ozturan, Seda es_ES
dc.contributor.author Azkargorta, Mikel es_ES
dc.contributor.author Elortza, Félix es_ES
dc.contributor.author Gurruchaga, Mariló es_ES
dc.contributor.author Suay, Julio es_ES
dc.contributor.author Goñi, Isabel es_ES
dc.date.accessioned 2021-09-09T03:35:12Z
dc.date.available 2021-09-09T03:35:12Z
dc.date.issued 2020-11 es_ES
dc.identifier.uri http://hdl.handle.net/10251/171683
dc.description.abstract [EN] Melatonin (MLT) is widely known for regulating the circadian cycles and has been studied for its role in bone regeneration and inflammation. Its application as a coating for dental implants can condition the local micro environment, affecting protein deposition on its surface and the cellular and tissue response. Using sol-gel coatings as a release vehicle for MLT, the aim of this work was to assess the potential of this molecule in improving the osseointegration and inflammatory responses of a titanium substrate. The materials obtained were physicochemically characterized (scanning electron microscopy, contact angle, roughness, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, Si release, MLT liberation, and degradation) and studied in vitro with MC3T3-E1 osteoblastic cells and RAW264.7 macrophage cells. Although MLT application led to an increased gene expression of RUNX2 and BMP2 in 10MTL, it did not improve ALP activity. On the other hand, MLT-enriched sol-gel materials presented potential effects in the adsorption of proteins related to inflammation, coagulation and angiogenesis pathways depending on the dosage used. Using LC-MS/MS, protein adsorption patterns were studied after incubation with human serum. Proteins related to the complement systems (CO7, IC1, CO5, CO8A, and CO9) were less adsorbed in materials with MLT; on the other hand, proteins with functions in the coagulation and angiogenesis pathways, such as A2GL and PLMN, showed a significant adsorption pattern. es_ES
dc.description.sponsorship This work was supported by MINECO [MAT MAT2017-86043-R; RTC-2017-6147-1], Universitat Jaume I under [UJI-B2017-37; POSDOC/2019/28], Generalitat Valenciana [GRISOLIAP/2018/091], University of the Basque Country under [UFI11/56] and Basque Government under [PRE_2017_2_0044]. CIC bioGUNE is supported by Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs), the Innovation Technology Department of the Bizkaia County; The ProteoRed-ISCIII (Grant PRB3 IPT17/0019); CIBERehd Network and Severo Ochoa Grant (SEV-2016-0644). Authors would like to thank Antonio Coso (GMI-Ilerimplant) for their inestimable contribution to this study, and Raquel Oliver, Jose Ortega (UJI) and Iraide Escobes (CIC bioGUNE) for their valuable technical assistance. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier BV es_ES
dc.relation.ispartof Materials Science and Engineering C: Materials for Biological Applications (Online) es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Osseointegration es_ES
dc.subject Hybrid sol-gel es_ES
dc.subject Inflammation es_ES
dc.subject Proteomics es_ES
dc.subject Coating es_ES
dc.subject N-acetyl-5-metoxy-tryptamine es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title A possible use of melatonin in the dental field: Protein adsorption and in vitro cell response on coated titanium es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.msec.2020.111262 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UJI//POSDOC%2F2019%2F28/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GRISOLIAP%2F2018%2F091/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Eusko Jaurlaritza//PRE_2017_2_0044/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//RTC-2017-6147-1/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-86043-R/ES/DESARROLLO DE IMPLANTES DENTALES CON PROPIEDADES OSTEOGENICAS PARA LA UNIVERSALIZACION DE RECEPTORES. DETERMINACION DE PATRONES DE PROTEINAS DE LA EFICACIA REGENERATIVA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UJI//UJI-B2017-37/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV%2FEHU//UFI11%2F56/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2016-0644/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PRB3 IPT17%2F0019/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Cerqueira, A.; Romero-Gavilán, F.; Araujo-Gomes, N.; García-Arnáez, I.; Martínez-Ramos, C.; Ozturan, S.; Azkargorta, M.... (2020). A possible use of melatonin in the dental field: Protein adsorption and in vitro cell response on coated titanium. Materials Science and Engineering C: Materials for Biological Applications (Online). 116:1-10. https://doi.org/10.1016/j.msec.2020.111262 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.msec.2020.111262 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 116 es_ES
dc.identifier.eissn 1873-0191 es_ES
dc.identifier.pmid 32806297 es_ES
dc.relation.pasarela S\433170 es_ES
dc.contributor.funder Universitat Jaume I es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Gobierno Vasco/Eusko Jaurlaritza es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Universidad del País Vasco/Euskal Herriko Unibertsitatea es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas es_ES
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