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Chromo-fluorogenic probes for beta-galactosidase detection

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Chromo-fluorogenic probes for beta-galactosidase detection

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dc.contributor.author Lozano-Torres, Beatriz es_ES
dc.contributor.author Blandez, Juan F. es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2022-01-28T07:41:07Z
dc.date.available 2022-01-28T07:41:07Z
dc.date.issued 2021-02-19 es_ES
dc.identifier.issn 1618-2642 es_ES
dc.identifier.uri http://hdl.handle.net/10251/180327
dc.description.abstract [EN] beta-Galactosidase (beta-Gal) is a widely used enzyme as a reporter gene in the field of molecular biology which hydrolyzes the beta-galactosides into monosaccharides. beta-Gal is an essential enzyme in humans and its deficiency or its overexpression results in several rare diseases. Cellular senescence is probably one of the most relevant physiological disorders that involve beta-Gal enzyme. In this review, we assess the progress made to date in the design of molecular-based probes for the detection of beta-Gal both in vitro and in vivo. Most of the reported molecular probes for the detection of beta-Gal consist of a galactopyranoside residue attached to a signalling unit through glycosidic bonds. The beta-Gal-induced hydrolysis of the glycosidic bonds released the signalling unit with remarkable changes in color and/or emission. Additional examples based on other approaches are also described. The wide applicability of these probes for the rapid and in situ detection of de-regulation beta-Gal-related diseases has boosted the research in this fertile field es_ES
dc.description.sponsorship R.M laboratory members received the financial support from the Spanish Government (project RTI2018-100910-B-C41) and the Generalitat Valenciana (project PROMETEO 2018/024). B.L-T. received support from the Spanish Ministry of Economy for their PhD grants (FPU15/02707). J. F.-B received fellowship (CD19/00038) es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Analytical and Bioanalytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Chromo-fluorogenic probes es_ES
dc.subject Beta-Galactosidase detection es_ES
dc.subject Cellular senescence es_ES
dc.subject In vitro and in vivo detection es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Chromo-fluorogenic probes for beta-galactosidase detection es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00216-020-03111-8 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Instituto de Salud Carlos III//"CD19%2F00038"//Contrato Sara Borrell/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECYD//FPU15%2F02707//NUEVOS MATERIALES HIBRIDOS PARA LA DETECCION DE MARCADORES BIOLOGICOS./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//PROMETEO%2F2018%2F024//SISTEMAS AVANZADOS DE LIBERACION CONTROLADA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Lozano-Torres, B.; Blandez, JF.; Sancenón Galarza, F.; Martínez-Máñez, R. (2021). Chromo-fluorogenic probes for beta-galactosidase detection. Analytical and Bioanalytical Chemistry. 413(9):2361-2388. https://doi.org/10.1007/s00216-020-03111-8 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s00216-020-03111-8 es_ES
dc.description.upvformatpinicio 2361 es_ES
dc.description.upvformatpfin 2388 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 413 es_ES
dc.description.issue 9 es_ES
dc.identifier.pmid 33606064 es_ES
dc.relation.pasarela S\444299 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder MINISTERIO DE EDUCACION es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
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