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Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial

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Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial

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dc.contributor.author Radosevic, Aleksandar es_ES
dc.contributor.author Quesada, Rita es_ES
dc.contributor.author Serlavos, Clara es_ES
dc.contributor.author Sánchez, Juan es_ES
dc.contributor.author Zugazaga, Ander es_ES
dc.contributor.author Sierra, Ana es_ES
dc.contributor.author Coll, Susana es_ES
dc.contributor.author Busto, Marcos es_ES
dc.contributor.author Aguilar, Guadalupe es_ES
dc.contributor.author Flores, Daniel es_ES
dc.contributor.author Arce, Javier es_ES
dc.contributor.author Maiques, Jose Maria es_ES
dc.contributor.author Garcia-Retortillo, Montserrat es_ES
dc.contributor.author Carrion, Jose Antonio es_ES
dc.contributor.author Visa, Laura es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.contributor.author Trujillo Guillen, Macarena es_ES
dc.date.accessioned 2022-04-27T06:27:47Z
dc.date.available 2022-04-27T06:27:47Z
dc.date.issued 2022-01-10 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/182125
dc.description.abstract [EN] Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA as well as morphology of corresponding ablation zones. HCC and MT patients with 1.5-4 cm tumors, suitable for ablation, were randomized into MWA or RFA Groups. The primary endpoint was short-to-long diameter ratio of ablation zone (SLR). Primary technical success (TS) and a cumulative local tumor progression (LTP) after a median 2-year follow-up were compared. Between June 2015 and April 2020, 82 patients were randomly assigned (41 patients per group). For the per-protocol analysis, five patients were excluded. MWA created larger ablation zones than RFA (p = 0.036) although without differences in SLR (0.5 for both groups, p = 0.229). The TS was achieved in 98% (46/47) and 90% (45/50) (p = 0.108), and LTP was observed in 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66-5.3], p = 0.238) of tumors in MWA vs. RFA Group, respectively. Major complications were found in 5 cases (11%) vs. 2 cases (4%), without statistical significance. MWA and RFA show similar SLR, effectiveness and safety in liver tumors between 1.5 and 4 cm. es_ES
dc.description.sponsorship This work was supported by a grant for medical research from Spanish Government (FIS-PI12/00799) and by the Spanish Ministerio de Ciencia, Innovacion y Universidades under "Programa Estatal de I+D+i Orientada a los Retos de la Sociedad", Grant RTI2018-094357-B-C21. es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-021-03802-x es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094357-B-C21/ES/MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MSC//FIS-PI12%2F00799/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Radosevic, A.; Quesada, R.; Serlavos, C.; Sánchez, J.; Zugazaga, A.; Sierra, A.; Coll, S.... (2022). Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial. Scientific Reports. 12(1):1-10. https://doi.org/10.1038/s41598-021-03802-x es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-021-03802-x es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 35013377 es_ES
dc.identifier.pmcid PMC8748896 es_ES
dc.relation.pasarela S\452951 es_ES
dc.contributor.funder Ministerio de Sanidad y Consumo es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
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