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dc.contributor.author | Verdú, Samuel | es_ES |
dc.contributor.author | Ruiz Rico, María | es_ES |
dc.contributor.author | Barat Baviera, José Manuel | es_ES |
dc.contributor.author | Grau Meló, Raúl | es_ES |
dc.date.accessioned | 2022-05-05T18:03:55Z | |
dc.date.available | 2022-05-05T18:03:55Z | |
dc.date.issued | 2021-01-25 | es_ES |
dc.identifier.issn | 0009-2797 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/182397 | |
dc.description.abstract | [EN] The effect of the presence of food on the incorporation and excretion of silica particles was studied in this work using the biological model Caenorhabditis elegans and image analysis techniques. The experiment was based on two 24-hour phases: exposure and depuration. During exposure, nematodes were maintained for 24 h in liquid medium with silica particles, but some with and others without food. During depuration, nematodes were transferred to medium without particles. Nematodes were analysed by an image analysis in both phases to quantify the properties of particle distributions in nematodes' bodies with time. No differences were found in the proportion of nematodes carrying particles in the exposure phase when food was present. However in the depuration phase, lack of food generated a high proportion of particle carriers. Particle distribution properties were also similar in the exposure phase. Nevertheless, lack of food produced particle accumulation due to decelerated excretion because digestive tube relaxed under these conditions. Thus after the depuration phase, lack of food led particles to persist in digestive tubes. According to these results, intake of silica particles had no retention effects when a food flux was provided, but particles were not easily excreted when the food flux was interrupted. | es_ES |
dc.description.sponsorship | The authors gratefully acknowledge the financial support from the Universitat Polit`ecnica de Valencia by Programme "Ayudas para la Contratacion de Doctores para el Acceso al Sistema Espanol de Ciencia, Tecnologia e Innovacion, en Estructuras de Investigacion de la UPV (PAID-10-17)"and Ministerio de Ciencia, Innovacion y Universidades, the Agencia Estatal de Investigacion and FEDER-EU (Project RTI2018101599-B-C21). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Chemico-Biological Interactions | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Silica particles | es_ES |
dc.subject | Uptake kinetics | es_ES |
dc.subject | Digestive tube | es_ES |
dc.subject | Image analysis | es_ES |
dc.subject | C.elegans | es_ES |
dc.subject.classification | TECNOLOGIA DE ALIMENTOS | es_ES |
dc.title | Evaluation of the influence of food intake on the incorporation and excretion kinetics of mesoporous silica particles in C.elegans | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.cbi.2020.109363 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C21/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UPV//PAID-10-17/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments | es_ES |
dc.description.bibliographicCitation | Verdú, S.; Ruiz Rico, M.; Barat Baviera, JM.; Grau Meló, R. (2021). Evaluation of the influence of food intake on the incorporation and excretion kinetics of mesoporous silica particles in C.elegans. Chemico-Biological Interactions. 334:1-8. https://doi.org/10.1016/j.cbi.2020.109363 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.cbi.2020.109363 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 8 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 334 | es_ES |
dc.identifier.pmid | 33358771 | es_ES |
dc.relation.pasarela | S\425332 | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |