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Comparative Transcriptome Profile between Iberian Pig Varieties Provides New Insights into Their Distinct Fat Deposition and Fatty Acids Content

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Comparative Transcriptome Profile between Iberian Pig Varieties Provides New Insights into Their Distinct Fat Deposition and Fatty Acids Content

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dc.contributor.author Villaplana-Velasco, Ana es_ES
dc.contributor.author Noguera, Jose Luis es_ES
dc.contributor.author Pena, Ramona Natacha es_ES
dc.contributor.author Ballester, Maria es_ES
dc.contributor.author Muñoz, Lourdes es_ES
dc.contributor.author González, Elena es_ES
dc.contributor.author Tejeda, Juan Florencio es_ES
dc.contributor.author Ibáñez-Escriche, Noelia es_ES
dc.date.accessioned 2022-05-25T18:04:03Z
dc.date.available 2022-05-25T18:04:03Z
dc.date.issued 2021-03 es_ES
dc.identifier.uri http://hdl.handle.net/10251/182917
dc.description.abstract [EN] Iberian pigs are meat quality models due to their high fat content, high intramuscular fat, and oleic fatty acid composition. These parameters present great variability and are differentiated among the lines that make up the Iberian pig population. However, there is little information on how the genetic expression influences quality across Iberian varieties. This study aimed to compare the muscle expression profile between two varieties of Iberian pig (Torbiscal and Retinto) and their reciprocal crosses, differentiated by fatness. Our results suggest that the Retinto variety, which has the greatest fat content amongst the studied Iberian varieties, showed a higher expression of genes related to adiposity. Likewise, a higher expression of genes related to lipolysis was found in the Torbiscal variety, described as having less fat content than Retinto. Further genetic variation analysis in these Iberian varieties showed relevant associations for SNP (Single Nucleotide Polymorphism), related to these differentially expressed genes, with the meat quality traits. Thus, our findings evidence that differences in the genetic architecture and expression of Iberian varieties might explain the variability in their fat content and composition and hence, their meat quality. The high deposition of intramuscular fat and the content of oleic fatty acid are characteristic of the Iberian pig. These two parameters present great variability and are differentiated amongst the varieties that make up the Iberian pig population. Although previous studies generated evidence for causal genes and polymorphisms associated to the adipogenic potential of the Iberian pig, there is little information about how genetic expression influences this trait's variability. The aim of this study was to analyses the expression profile between two varieties of Iberian pig (Torbiscal and Retinto) and their reciprocal crosses differentiated in their intramuscular fat (IMF) content and fatty acid (FA) composition in the Longissimus thoracis muscle using an RNA-seq approach. Our results corroborate that the Retinto variety is the fattiest amongst all studied varieties as its upregulated genes, such as FABP3 and FABP5, SLC27A1 and VEGFA among others, contribute to increasing adiposity. In its turn, Torbiscal pigs showed an upregulation of genes associated with the inhibition of fat deposition such as ADIPOQ and CPT1A. Further genetic variation analysis in these Iberian varieties showed relevant associations for SNP located within the differentially expressed genes with IMF and FA content. Thus, the differences found in the genetic architecture and the muscle transcriptome of these Iberian varieties might explain the variability in their fat content and composition and hence, their meat quality. es_ES
dc.description.sponsorship This study was funded by the INIA grant RTA 2012-0054-C02-01* and the Centre for the Development of Industrial Technology grant IDI-20140447. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Animals es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Transcriptomics es_ES
dc.subject Iberian pig es_ES
dc.subject Adipogenic potential es_ES
dc.subject Meat quality es_ES
dc.subject RNA-seq es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Comparative Transcriptome Profile between Iberian Pig Varieties Provides New Insights into Their Distinct Fat Deposition and Fatty Acids Content es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/ani11030627 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//IDI-20140447/ES/PROGRAMA DE SELECCIÓN Y MEJORA GENÉTICA DE ESTRUCTURA PIRAMIDAL EN PORCINO IBÉRICO QUE INCORPORE LA INFORMACIÓN DE DOS LÍNEAS PARENTALES PURAS (ENTREPELADA Y RETINTA) Y DE LA LÍNEA  COMERCIAL CASTÚA (ENTREPELADA X RETINTA)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RTA2012-00054-C02-01/ES/Utilización de información genómica masiva para mejorar la calidad de los productos de cerdo ibérico en una población de referencia mixta y el estudio de su interacción con la alimentación/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Villaplana-Velasco, A.; Noguera, JL.; Pena, RN.; Ballester, M.; Muñoz, L.; González, E.; Tejeda, JF.... (2021). Comparative Transcriptome Profile between Iberian Pig Varieties Provides New Insights into Their Distinct Fat Deposition and Fatty Acids Content. Animals. 11(3):1-14. https://doi.org/10.3390/ani11030627 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/ani11030627 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 14 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 3 es_ES
dc.identifier.eissn 2076-2615 es_ES
dc.identifier.pmid 33673436 es_ES
dc.identifier.pmcid PMC7997154 es_ES
dc.relation.pasarela S\430141 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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