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Development of Decellularized Oviductal Hydrogels as a Support for Rabbit Embryo Culture

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Development of Decellularized Oviductal Hydrogels as a Support for Rabbit Embryo Culture

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dc.contributor.author Francés-Herrero, Emilio es_ES
dc.contributor.author De Miguel-Gómez, Lucía es_ES
dc.contributor.author López-Martínez, Sara es_ES
dc.contributor.author Campo, Hannes es_ES
dc.contributor.author Garcia-Dominguez, Ximo es_ES
dc.contributor.author Diretto, Gianfranco es_ES
dc.contributor.author Faus, Amparo es_ES
dc.contributor.author Vicente Antón, José Salvador es_ES
dc.contributor.author Marco-Jiménez, Francisco es_ES
dc.contributor.author Cervelló, Irene es_ES
dc.date.accessioned 2022-07-19T18:06:08Z
dc.date.available 2022-07-19T18:06:08Z
dc.date.issued 2021-06 es_ES
dc.identifier.issn 1933-7191 es_ES
dc.identifier.uri http://hdl.handle.net/10251/184452
dc.description.abstract [EN] The oviducts (fallopian tubes in mammals) function as the site of fertilization and provide necessary support for early embryonic development, mainly via embryonic exposure to the tubal microenvironment. The main objective of this study was to create an oviduct-specific extracellular matrix (oviECM) hydrogel rich in bioactive components that mimics the native environment, thus optimizing the developmental trajectories of cultured embryos. Rabbit oviducts were decellularized through SDS treatment and enzymatic digestion, and the acellular tissue was converted into oviductal pre-gel extracellular matrix (ECM) solutions. Incubation of these solutions at 37 degrees C resulted in stable hydrogels with a fibrous structure based on scanning electron microscopy. Histological staining, DNA quantification and colorimetric assays confirmed that the decellularized tissue and hydrogels contained no cellular or nuclear components but retained important components of the ECM, e.g. hyaluronic acid, glycoproteins and collagens. To evaluate the ability of oviECM hydrogels to maintain early embryonic development, two-cell rabbit embryos were cultured on oviECM-coated surfaces and compared to those cultured with standard techniques. Embryo development was similar in both conditions, with 95.9% and 98% of the embryos reaching the late morula/early blastocyst stage by 48 h under standard culture and oviECM conditions, respectively. Metabolomic analysis of culture media in the presence or absence of embryos, however, revealed that the oviECM coating may include signalling molecules and release compounds beneficial to embryo metabolism. es_ES
dc.description.sponsorship This study was supported by Instituto de Salud Carlos III (PI17/01039-CP19/00149 [Irene Cervello]), Ministry of Economy, Industry and Competitiveness (AGL2017-85162-C2-1-R [Francisco Marco], BES-2015-072429 [Ximo Garcia]), Ministry of Science, Innovation and Universities (FPU18/06327 [Emilio Frances]) and Generalitat Valenciana (PROMETEO/2018/137 [Irene Cervello, Lucia de Miguel], ACIF/2017/118 [Sara Lopez]). The proteomics laboratory is a member of ProteoRed, PRB3, and is supported by grant PT17/0019 of the State Plan I+D+i 2013-2016, funded by Instituto de Salud Carlos III and European Regional Development Fund. es_ES
dc.language Inglés es_ES
dc.publisher SAGE Publications es_ES
dc.relation.ispartof Reproductive Sciences es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Decellularization es_ES
dc.subject Hydrogel es_ES
dc.subject Oviduct es_ES
dc.subject Fallopian tubes es_ES
dc.subject ECM es_ES
dc.subject Embryo culture es_ES
dc.subject.classification BIOLOGIA ANIMAL es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Development of Decellularized Oviductal Hydrogels as a Support for Rabbit Embryo Culture es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s43032-020-00446-6 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-85162-C2-1-R/ES/MEJORA GENETICA DEL CONEJO DE CARNE: ESTRATEGIAS PARA INCREMENTAR LA EFICACIA DE LA MEJORA, REPRODUCCION Y SALUD DE LINEAS PATERNALES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MCIU//FPU18%2F06327/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-072429/ES/BES-2015-072429/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//CP19%2F00149/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PT17%2F0019/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-072429//BES-2015-072429/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI17%2F01039/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//Prometeo%2F2018%2F137/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACIF%2F2017%2F118/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Francés-Herrero, E.; De Miguel-Gómez, L.; López-Martínez, S.; Campo, H.; Garcia-Dominguez, X.; Diretto, G.; Faus, A.... (2021). Development of Decellularized Oviductal Hydrogels as a Support for Rabbit Embryo Culture. Reproductive Sciences. 28(6):1644-1658. https://doi.org/10.1007/s43032-020-00446-6 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s43032-020-00446-6 es_ES
dc.description.upvformatpinicio 1644 es_ES
dc.description.upvformatpfin 1658 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 28 es_ES
dc.description.issue 6 es_ES
dc.identifier.pmid 33511539 es_ES
dc.relation.pasarela S\455816 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES
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