San Antonio, R.; Guasch, E.; González-Ascaso, A.; Jiménez-Arjona, R.; Climent, AM.; Pujol-López, M.; Doltra, A.... (2021). Optimized single-point left ventricular pacing leads to improved resynchronization compared with multipoint pacing. Pacing and Clinical Electrophysiology. 44(3):519-527. https://doi.org/10.1111/pace.14185
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/184695
Título:
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Optimized single-point left ventricular pacing leads to improved resynchronization compared with multipoint pacing
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Autor:
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San Antonio, Rodolfo
Guasch, Eduard
González-Ascaso, Ana
Jiménez-Arjona, Rafael
Climent, Andreu M.
Pujol-López, Margarida
Doltra, Adelina
Alarcón, Francisco
Garre, Paz
Liberos Mascarell, Alejandro
Trotta, Omar
Quinto, Levio
Borras, Roger
Arbelo, Elena
Roca-Luque, Ivo
Atienza, Felipe
Brugada, Josep
Fernandez-Aviles, Francisco
Guillem Sánchez, María Salud
Sitges, Marta
Tolosana, José María
Mont, Lluis
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Entidad UPV:
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
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Fecha difusión:
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Resumen:
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[EN] Background Multipoint pacing (MPP) in cardiac resynchronization therapy (CRT) activates the left ventricle from two locations, thereby shortening the QRS duration and enabling better resynchronization; however, compared ...[+]
[EN] Background Multipoint pacing (MPP) in cardiac resynchronization therapy (CRT) activates the left ventricle from two locations, thereby shortening the QRS duration and enabling better resynchronization; however, compared with conventional CRT, MPP reduces battery longevity. On the other hand, electrocardiogram-based optimization using the fusion-optimized intervals (FOI) method achieves more significant reverse remodeling than nominal CRT programming. Our study aimed to determine whether MPP could attain better resynchronization than single-point pacing (SPP) optimized by FOI.
Methods This prospective study included 32 consecutive patients who successfully received CRT devices with MPP capabilities. After implantation, the QRS duration was measured during intrinsic rhythm and with three pacing configurations: MPP, SPP-FOI, and MPP-FOI. In 14 patients, biventricular activation times (by electrocardiographic imaging, ECGI) were obtained during intrinsic rhythm and for each pacing configuration to validate the findings. Device battery longevity was estimated at the 45-day follow-up.
Results The SPP-FOI method achieved greater QRS shortening than MPP (-56 +/- 16 vs. -42 +/- 17 ms, p < .001). Adding MPP to the best FOI programming did not result in further shortening (MPP-FOI: -58 +/- 14 ms, p = .69). Although biventricular activation times did not differ significantly among the three pacing configurations, only the two FOI configurations achieved significant shortening compared with intrinsic rhythm. The estimated battery longevity was longer with SPP than with MPP (8.1 +/- 2.3 vs. 6.3 +/- 2.0 years, p = .03).
Conclusions SPP optimized by FOI resulted in better resynchronization and longer battery duration than MPP.
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Palabras clave:
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Battery longevity
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Cardiac resynchronization therapy
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Electrocardiographic imaging
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Fusion-
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Optimized intervals
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Multipoint pacing
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Derechos de uso:
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Cerrado |
Fuente:
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Pacing and Clinical Electrophysiology. (issn:
0147-8389
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DOI:
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10.1111/pace.14185
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Editorial:
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Blackwell Publishing
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Versión del editor:
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https://doi.org/10.1111/pace.14185
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Código del Proyecto:
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info:eu-repo/grantAgreement/EC/H2020/633196/EU
...[+]
info:eu-repo/grantAgreement/EC/H2020/633196/EU
info:eu-repo/grantAgreement/ISCIII//DTS16%2F0160 /
info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00354/ES/ENFERMEDADES CARDIOVASCULARES/
info:eu-repo/grantAgreement/ISCIII//SEC_ESTIM_01/
info:eu-repo/grantAgreement/MINECO//PI16%2F00435/ES/Ablación de fibrilación auricular guiada por resonancia magnética: Estudio randomizado de la eficacia de la identificación y aislamiento de las zonas de fibrosis/
info:eu-repo/grantAgreement/AGAUR//2017_SGR_1548/
info:eu-repo/grantAgreement/MINECO//PI16%2F00703/ES/Caracterización del remodelado a dosis crecientes de ejercicio físico como sustrato para el desarrollo de patología inducida por ejercicio/
info:eu-repo/grantAgreement/Fundació La Marató de TV3//20152730/
info:eu-repo/grantAgreement/FEDER//EITHealth 19600 AFFINE/
info:eu-repo/grantAgreement/ISCIII//PI17%2F01059/
info:eu-repo/grantAgreement/INSTITUTO DE SALUD CARLOS III//PI17%2F01106//ESTRATIFICACION Y TRATAMIENTO DE LA FIBRILACION AURICULAR BASADA EN LOS MECANISMOS DE PERPETUACION DE LA ARRITMIA/
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Agradecimientos:
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Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares, Grant/Award Number: CB16/11/00354; Instituto de Salud Carlos III, Grant/Award Numbers: DTS16/0160, PI16/00435, PI16/00703, PI17/01059, PI17/01106; ...[+]
Centro de Investigacion Biomedica en Red Enfermedades Cardiovasculares, Grant/Award Number: CB16/11/00354; Instituto de Salud Carlos III, Grant/Award Numbers: DTS16/0160, PI16/00435, PI16/00703, PI17/01059, PI17/01106; Sociedad Espanola de Cardiologia, Grant/Award Numbers: 2018, SEC_ESTIM_01; Agencia deGestio d'Ajuts Universitaris i de Recerca, Grant/AwardNumber: 2017_SGR_1548; Fundacio laMarato de TV3, Grant/Award Number: 20152730; Horizon 2020 Framework Programme, Grant/Award Number: 633196 - CATCH MEproject; European Regional Development Fund, Grant/Award Number: EITHealth 19600 AFFINE
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Tipo:
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Artículo
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