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In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model

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In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model

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dc.contributor.author Latorre, Marcos es_ES
dc.contributor.author Szafron, Jason M. es_ES
dc.contributor.author Ramachandra, Abhay B. es_ES
dc.contributor.author Humphrey, Jay D. es_ES
dc.date.accessioned 2022-11-03T10:38:20Z
dc.date.available 2022-11-03T10:38:20Z
dc.date.issued 2022-02-18 es_ES
dc.identifier.issn 1617-7959 es_ES
dc.identifier.uri http://hdl.handle.net/10251/189080
dc.description.abstract [EN] Methods of tissue engineering continue to advance, and multiple clinical trials are underway evaluating tissue engineered vascular grafts (TEVGs). Whereas initial concerns focused on suture retention and burst pressure, there is now a pressing need to design grafts to have optimal performance, including an ability to grow and remodel in response to changing hemodynamic loads. Toward this end, there is similarly a need for computational methods that can describe and predict the evolution of TEVG geometry, composition, and material properties while accounting for changes in hemodynamics. Although the ultimate goal is a fluid-solid-growth (FSG) model incorporating fully 3D growth and remodeling and 3D hemodynamics, lower fidelity models having high computational efficiency promise to play important roles, especially in the design of candidate grafts. We introduce here an efficient FSG model of in vivo development of a TEVG based on two simplifying concepts: mechanobiologically equilibrated growth and remodeling of the graft and an embedded control volume analysis of the hemodynamics. Illustrative simulations for a model Fontan conduit reveal the utility of this approach, which promises to be particularly useful in initial design considerations involving formal methods of optimization which otherwise add considerably to the computational expense. es_ES
dc.description.sponsorship This research was supported by grants from the NIH (R01 HL128602, R01 HL139796) and DoD/USAMRAA (W81 XWH1810518). es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Biomechanics and Modeling in Mechanobiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Tissue engineering es_ES
dc.subject Fontan procedure es_ES
dc.subject TEVG es_ES
dc.subject Neovessel es_ES
dc.subject Fluid-solid-growth es_ES
dc.title In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10237-022-01562-9 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01 HL128602//Computational Model Driven Design of Tissue Engineered Vascular Grafts/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01 HL139796//Improving Tissue Engineered Vascular Graft Performance via Computational Modeling/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/DOD//W81 XWH1810518//Development and Preclinical Validation of an Improved Tissue-Engineered Vascular Graft for Use in Congenital Surgery/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Investigación e Innovación en Bioingeniería - Centre de Recerca i Innovació en Bioenginyeria es_ES
dc.description.bibliographicCitation Latorre, M.; Szafron, JM.; Ramachandra, AB.; Humphrey, JD. (2022). In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model. Biomechanics and Modeling in Mechanobiology. 21:827-848. https://doi.org/10.1007/s10237-022-01562-9 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s10237-022-01562-9 es_ES
dc.description.upvformatpinicio 827 es_ES
dc.description.upvformatpfin 848 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.identifier.pmid 35179675 es_ES
dc.identifier.pmcid PMC9133046 es_ES
dc.relation.pasarela S\457250 es_ES
dc.contributor.funder U.S. Department of Defense es_ES
dc.contributor.funder National Institutes of Health, EEUU es_ES
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dc.subject.ods 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades es_ES


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