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Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing.

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Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing.

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dc.contributor.author Sarreshtehdari, Amirhossein es_ES
dc.contributor.author Burdio, Fernando es_ES
dc.contributor.author López-Alonso, Borja es_ES
dc.contributor.author Lucia, Oscar es_ES
dc.contributor.author Burdio, José Miguel es_ES
dc.contributor.author Villamonte, Maria es_ES
dc.contributor.author Andaluz, A. es_ES
dc.contributor.author García-Arnás, F. es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.contributor.author Moll, Xavier es_ES
dc.date.accessioned 2023-05-12T18:02:13Z
dc.date.available 2023-05-12T18:02:13Z
dc.date.issued 2023-05-02 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/193333
dc.description.abstract [EN] Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 min. Group 2.2 at 0.03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE¿s effects on healthy tissue. es_ES
dc.description.sponsorship This research was supported by the Spanish government (Ministry of Economy and Competitiveness) under Grants RTI2018-094357-B-C21, RTI2018-094357-B-C22 and Carlos III Health Institute under Grant PI17/0048 and also PI21/00440 from the same institution. es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing. es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-023-33487-3 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094357-B-C21/ES/MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI17%2F0048/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094357-B-C22/ES/INVESTIGACION QUIRURGICA PARA TERAPIAS ABLATIVAS INNOVADORAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00440/ES/EFECTOS DE LA ELETROPORACION Y LA ELECTROQUIMIOTERAPIA EN LA DESTRUCCION LOCALIZADA DE TUMORES HEPATICOS EN MODELO PORCINO EXPERIMENTAL/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Sarreshtehdari, A.; Burdio, F.; López-Alonso, B.; Lucia, O.; Burdio, JM.; Villamonte, M.; Andaluz, A.... (2023). Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing. Scientific Reports. 13(1):1-9. https://doi.org/10.1038/s41598-023-33487-3 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-023-33487-3 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 9 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 37130847 es_ES
dc.identifier.pmcid PMC10154417 es_ES
dc.relation.pasarela S\491865 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
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