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In vitro susceptibility of human gut microbes to potential food preservatives based on immobilized phenolic compounds

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In vitro susceptibility of human gut microbes to potential food preservatives based on immobilized phenolic compounds

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dc.contributor.author Ruiz Rico, María es_ES
dc.contributor.author Renwick, Simone es_ES
dc.contributor.author Allen-Vercoe, Emma es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.date.accessioned 2023-07-12T18:00:49Z
dc.date.available 2023-07-12T18:00:49Z
dc.date.issued 2022-06-01 es_ES
dc.identifier.issn 0308-8146 es_ES
dc.identifier.uri http://hdl.handle.net/10251/194866
dc.description.abstract [EN] The development of novel food preservatives based on natural antimicrobials such as phenolic compounds is increasing, but their safety should be established before use, including evaluating their impact on the gut microbiota. This work explored the influence of antimicrobial phenolics presented in different forms on selected human gut microbiota members through in vitro susceptibility tests. The bacteria tested exhibited a wide range of susceptibilities to phenolics depending on the molecule structure and mode of administration. Agathobacter rectalis and Clostridium spiroforme, members of the phylum Firmicutes, were the most sensitive strains. Susceptibility was strain- and species-specific, suggesting that it may not be possible to easily extrapolate results across the human microbiome in general. Species of other phyla including Bacteroidetes, Actinobacteria, Proteobacteria and Verrucomicrobia were more resistant than Firmicutes, with growth of some strains even enhanced. Our results provide insights into the biocompatibility of free and immobilized phenolics as potential food additives. es_ES
dc.description.sponsorship The authors gratefully acknowledge the financial support from the grant RTI2018-101599-B-C21 of the project "Retos Investigacion" funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe". MRR acknowledges the Generalitat Valenciana for her postdoctoral fellowship (APOSTD/2019/118). We also thank A. V. Robinson and S. J. Vancuren for providing stock of the isolated gut microbiota strains. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Food Chemistry es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Gut microbiota es_ES
dc.subject Natural antimicrobial es_ES
dc.subject Covalent immobilization es_ES
dc.subject Food additives es_ES
dc.subject Agathobacter es_ES
dc.subject Clostridium es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title In vitro susceptibility of human gut microbes to potential food preservatives based on immobilized phenolic compounds es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.foodchem.2022.132136 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101599-B-C21/ES/DESARROLLO Y APLICACION DE SISTEMAS ANTIMICROBIANOS PARA LA INDUSTRIA ALIMENTARIA BASADOS EN SUPERFICIES FUNCIONALIZADAS Y SISTEMAS DE LIBERACION CONTROLADA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//APOSTD%2F2019%2F118//CONTRATO POSDOCTORAL GVA-RUIZ RICO. PROYECTO: DESARROLLO DE NUEVOS SISTEMAS ANTIMICROBIANOS / es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Ruiz Rico, M.; Renwick, S.; Allen-Vercoe, E.; Barat Baviera, JM. (2022). In vitro susceptibility of human gut microbes to potential food preservatives based on immobilized phenolic compounds. Food Chemistry. 378:1-10. https://doi.org/10.1016/j.foodchem.2022.132136 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.foodchem.2022.132136 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 378 es_ES
dc.identifier.pmid 35042114 es_ES
dc.relation.pasarela S\454081 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.subject.ods 02.- Poner fin al hambre, conseguir la seguridad alimentaria y una mejor nutrición, y promover la agricultura sostenible es_ES


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