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dc.contributor.author | Lambré, Claude![]() |
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dc.contributor.author | Barat Baviera, José Manuel![]() |
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dc.contributor.author | Bolognesi, Claudia![]() |
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dc.contributor.author | Cocconcelli, Pier Sandro![]() |
es_ES |
dc.contributor.author | Crebelli, Riccardo![]() |
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dc.contributor.author | Gott, David Michael![]() |
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dc.contributor.author | Grob, Konrad![]() |
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dc.contributor.author | Lampi, Evgenia![]() |
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dc.contributor.author | Mengelers, Marcel![]() |
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dc.contributor.author | Mortensen, Alicja![]() |
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dc.contributor.author | Rivière, Gilles![]() |
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dc.contributor.author | Steffensen, Inger-Lise![]() |
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dc.contributor.author | Tlustos, Christina![]() |
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dc.contributor.author | van Loveren, Henk![]() |
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dc.contributor.author | Vernis, Laurence![]() |
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dc.date.accessioned | 2023-07-13T18:02:27Z | |
dc.date.available | 2023-07-13T18:02:27Z | |
dc.date.issued | 2022-08 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/194938 | |
dc.description.abstract | [EN] The food enzyme phosphoinositide phospholipase C (1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase, EC 3.1.4.11) is produced with the genetically modified Bacillus licheniformis strain NZYM-DI by Novozymes A/S. The genetic modifications did not give rise to safety concerns. The production strain has been shown to qualify for the qualified presumption of safety (QPS) status. The food enzyme was considered free from viable cells of the production organism and its DNA. It is intended to be used for degumming of fats and oils. Since residual amounts of total organic solids are removed during washing and purification steps applied during degumming, dietary exposure was not estimated. As the production strain B. licheniformis NZYM-DI qualifies for the QPS approach to safety assessment and no issue of concern arose from the production process, no toxicological data were required. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure could not be excluded, but the likelihood for this to occur was considered low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use. | es_ES |
dc.description.sponsorship | The CEP Panel wishes to thank Erik Boinowitz for the support provided to this scientific output | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Willey | es_ES |
dc.relation.ispartof | EFSA Journal | es_ES |
dc.rights | Reconocimiento - Sin obra derivada (by-nd) | es_ES |
dc.subject | Food enzyme | es_ES |
dc.subject | Phosphoinositide phospholipase C | es_ES |
dc.subject | EC 3.1.4.11 | es_ES |
dc.subject | Triphosphoinositide phosphodiesterase | es_ES |
dc.subject | Bacillus licheniformis | es_ES |
dc.subject | Genetically modified microorganism | es_ES |
dc.subject.classification | TECNOLOGIA DE ALIMENTOS | es_ES |
dc.title | Safety evaluation of the food enzyme phosphoinositide phospholipase C from the genetically modified Bacillus licheniformis strain NZYM-DI | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.2903/j.efsa.2022.7470 | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Lambré, C.; Barat Baviera, JM.; Bolognesi, C.; Cocconcelli, PS.; Crebelli, R.; Gott, DM.; Grob, K.... (2022). Safety evaluation of the food enzyme phosphoinositide phospholipase C from the genetically modified Bacillus licheniformis strain NZYM-DI. EFSA Journal. 20(8):1-11. https://doi.org/10.2903/j.efsa.2022.7470 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.2903/j.efsa.2022.7470 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 11 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 20 | es_ES |
dc.description.issue | 8 | es_ES |
dc.identifier.eissn | 1831-4732 | es_ES |
dc.identifier.pmid | 35949931 | es_ES |
dc.identifier.pmcid | PMC9358538 | es_ES |
dc.relation.pasarela | S\483184 | es_ES |