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CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance

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CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance

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dc.contributor.author A. Gil es_ES
dc.contributor.author Navarro, Roberto es_ES
dc.contributor.author Quintero-Igeño, Pedro-Manuel es_ES
dc.contributor.author Mares-Bou, Andrea es_ES
dc.contributor.author Pérez, Manuel es_ES
dc.contributor.author Montero, Anastasio es_ES
dc.date.accessioned 2023-09-08T18:00:53Z
dc.date.available 2023-09-08T18:00:53Z
dc.date.issued 2022-08 es_ES
dc.identifier.issn 1617-7959 es_ES
dc.identifier.uri http://hdl.handle.net/10251/196138
dc.description.abstract [EN] Mechanical circulatory support using ventricular assist devices has become commonplace in the treatment of patients suffering from advanced stages of heart failure. While blood damage generated by these devices has been evaluated in depth, their hemodynamic performance has been investigated much less. This work presents the analysis of the complete operating map of a left ventricular assist device, in terms of pressure head, power and efficiency. Further investigation into its hemocompatibility is included as well. To achieve these objectives, computational fluid dynamics simulations of a centrifugal blood pump with a wide-blade impeller were performed. Several conditions were considered by varying the rotational speed and volumetric flow rate. Regarding the device's hemocompatibility, blood damage was evaluated by means of the hemolysis index. By relating the hemocompatibility of the device to its hemodynamic performance, the results have demonstrated that the highest hemolysis occurs at low flow rates, corresponding to operating conditions of low efficiency. Both performance and hemocompatibility are affected by the gap clearance. An innovative investigation into the influence of this design parameter has yielded decreased efficiencies and increased hemolysis as the gap clearance is reduced. As a further novelty, pump operating maps were non-dimensionalized to highlight the influence of Reynolds number, which allows their application to any working condition. The pump's operating range places it in the transitional regime between laminar and turbulent, leading to enhanced efficiency for the highest Reynolds number. es_ES
dc.description.sponsorship This study was partially funded by UPV-La Fe through the innovation projects subprogram (reference MODELVAD). es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Biomechanics and Modeling in Mechanobiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Centrifugal blood pump es_ES
dc.subject Operating map es_ES
dc.subject Non-dimensional analysis es_ES
dc.subject Gap clearance es_ES
dc.subject Shear stress es_ES
dc.subject Hemolysis es_ES
dc.subject.classification INGENIERIA AEROESPACIAL es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10237-022-01585-2 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation A. Gil; Navarro, R.; Quintero-Igeño, P.; Mares-Bou, A.; Pérez, M.; Montero, A. (2022). CFD analysis of the HVAD's hemodynamic performance and blood damage with insight into gap clearance. Biomechanics and Modeling in Mechanobiology. 21(4):1201-1215. https://doi.org/10.1007/s10237-022-01585-2 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s10237-022-01585-2 es_ES
dc.description.upvformatpinicio 1201 es_ES
dc.description.upvformatpfin 1215 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 4 es_ES
dc.identifier.pmid 35546646 es_ES
dc.relation.pasarela S\481669 es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Hospital Universitari i Politècnic La Fe es_ES
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