González-Cardenete, MA.; Hamulic, D.; Miquel-Leal, FJ.; González-Zapata, N.; Jimenez-Jarava, OJ.; Brand, YM.; Restrepo-Mendez, LC.... (2022). Antiviral Profiling of C-18-or C-19-Functionalized Semisynthetic Abietane Diterpenoids. Journal of Natural Products. 85(8):2044-2051. https://doi.org/10.1021/acs.jnatprod.2c00464
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/197357
Título:
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Antiviral Profiling of C-18-or C-19-Functionalized Semisynthetic Abietane Diterpenoids
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Autor:
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González-Cardenete, Miguel A
Hamulic, Damir
Miquel-Leal, Francisco J.
González-Zapata, Natalia
Jimenez-Jarava, Orlando J.
Brand, Yaneth M.
Restrepo-Mendez, Laura C.
Martinez-Gutierrez, Marlen
Betancur-Galvis, Liliana A.
Marín García, Mª Luisa
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Entidad UPV:
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Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
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Fecha difusión:
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Resumen:
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[EN] Viral infections affect several million patients annually. Although hundreds of viruses are known to be pathogenic, only a few can be treated in the clinic with available antiviral drugs. Naturally based pharmacotherapy ...[+]
[EN] Viral infections affect several million patients annually. Although hundreds of viruses are known to be pathogenic, only a few can be treated in the clinic with available antiviral drugs. Naturally based pharmacotherapy may be a proper alternative for treating viral diseases. Several natural and semisynthetic abietane-type diterpenoids have shown important antiviral activities. In this study, a biological evaluation of a number of either C-18-or C-19-functionalized known semisynthetic abietanes against Zika virus, Dengue virus, Herpes virus simplex type 1, and Chikungunya virus are reported. Semisynthetic abietane ferruginol and its analogue 18-(phthalimid-2-yl)ferruginol displayed broad-spectrum anti-viral properties. The scale-up synthesis of this analogue has been optimized for further studies and development. This molecule displayed an EC50 between 5.0 and 10.0 mu M against Colombian Zika virus strains and EC50 = 9.8 mu M against Chikungunya virus. Knowing that this ferruginol analogue is also active against Dengue virus type 2 (EC50 = 1.4 mu M, DENV-2), we can conclude that this compound is a promising broad-spectrum antiviral agent paving the way for the development of novel antivirals.
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Palabras clave:
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Antiviral
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Dengue
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Zika
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Chikungunya
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Abietane
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Diterpenoid
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Derechos de uso:
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Reconocimiento (by)
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Fuente:
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Journal of Natural Products. (issn:
0163-3864
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DOI:
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10.1021/acs.jnatprod.2c00464
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Editorial:
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American Chemical Society
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Versión del editor:
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https://doi.org/10.1021/acs.jnatprod.2c00464
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Código del Proyecto:
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info:eu-repo/grantAgreement/UPV.CCD//AD1902//DISEÑO, DESARROLO Y CARACTERIZACION DE ANTIVIRALES FLUORESCENTES DE PRODUCCION SOSTENIBLE PARA ENFERMEDADES TROPICALES Y CO-INFECCIONES OPORTUNISTAS EN VIH DE ALTA PREVALENCIA EN AMERICA LATINA./
info:eu-repo/grantAgreement/Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)//RC648-2017//MOLÉCULAS SINTÉTICAS CON POTENCIAL ANTI-DENGUE COMO UNA ALTERNATIVA PARA EL CONTROL DE LA INFECCIÓN IN VITRO POR VIRUS ZIKA/
info:eu-repo/grantAgreement/Minciencias//141577757439/
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Agradecimientos:
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Financial support from the Universitat Polite`cnica de Valencia, under a cooperation "ADSIDEO" research grant (AD1902), is gratefully acknowledged. N.G.Z. thanks the Universitat Polite`cnica de Valencia for a cooperation ...[+]
Financial support from the Universitat Polite`cnica de Valencia, under a cooperation "ADSIDEO" research grant (AD1902), is gratefully acknowledged. N.G.Z. thanks the Universitat Polite`cnica de Valencia for a cooperation scholarship MERIDIES-2020 to travel for a research stay to Colombia. We acknowledge the financial support from Colciencias (Patrimonio Autonomo del Fondo Nacional de Financiamiento para la Ciencia, la Tecnologia y la Innovacion, Francisco Jose de Caldas-Colombia)/Grant 744 2016 (contract 648-2017/project 111574455595) and CODI (Comite para el Desarrollo de la Investigacion-Universidad de Antioquia)/ Grant "Apoyo a la Internacionalizacion de la Ciencia-Vicerrectoria de Investigacion UdeA". Additionally, the authors acknowledge Dr. Vicky C. Roa-Linares for her contributions in the design of the molecular docking study and the virology groups of Universidad de Antioquia-Facultad de Medicina and "Direccion de Redes en Salud Publica, Instituto Nacional de Salud, Bogota, DC, Colombia" for providing the viruses. This research was also funded by Minciencias (Ministerio de Ciencia Tecnologia e Innovacion Departamento Administra-tivo de Ciencia, Tecnologia e Investigacion, Colombia) project 141577757439. We thank CSIC for covering the open access fees through the agreement CRUE-CSIC with ACS.
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Tipo:
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Artículo
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