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Effect of Ethanol Consumption on the Accuracy of a Glucose Oxidase-Based Subcutaneous Glucose Sensor in Subjects with Type 1 Diabetes

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Effect of Ethanol Consumption on the Accuracy of a Glucose Oxidase-Based Subcutaneous Glucose Sensor in Subjects with Type 1 Diabetes

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dc.contributor.author Moscardó, Vanessa es_ES
dc.contributor.author Garcia, Alia es_ES
dc.contributor.author Bondía Company, Jorge es_ES
dc.contributor.author Diaz, Julián es_ES
dc.contributor.author Ramos-Prol, Agustín es_ES
dc.contributor.author Rossetti, Paolo es_ES
dc.date.accessioned 2023-10-24T18:01:52Z
dc.date.available 2023-10-24T18:01:52Z
dc.date.issued 2022-05 es_ES
dc.identifier.uri http://hdl.handle.net/10251/198754
dc.description.abstract [EN] Continuous glucose monitors (CGM) have improved the management of patients with type 1 diabetes (T1D), with glucose oxidase (GOx)-based sensors being the most used. However, they are potentially subject to both electrochemical and enzymatic interferences, including those related to changes of pH. The objective of this study is to investigate the effect of ethanol, given as beer along with a mixed meal, on the accuracy of a commercial GOx-CGM. Data from 12 T1D participants in a randomized crossover trial to evaluate the effect of meal composition and alcohol consumption on postprandial glucose concentration were used. Absolute error (AE) and mean absolute relative difference (MARD) were calculated. The differences between the alcohol and nonalcohol scenarios were assessed using the Mann-Whitney U and Wilcoxon signed-rank tests. The AE in the alcohol study was low, but significantly greater as compared to the study without alcohol (p-value = 0.0418). The MARD was numerically but not significantly greater. However, both variables were greater at pH < 7.36 and significantly affected by time only in the alcohol arm. In T1D, alcohol consumption affects the accuracy of a GOx-CGM. This effect could be at least partially related to the ethanol-induced changes in pH. es_ES
dc.description.sponsorship This research was funded by grant DPI2016-78831-C2-1-R funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe"; and grant PID2019-107722RBC21 funded by MCIN/AEI/10.13039/501100011033. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Sensors es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Type 1 diabetes es_ES
dc.subject Alcohol es_ES
dc.subject Glucose-sensor accuracy es_ES
dc.subject Glucose oxidase-based sensors es_ES
dc.subject Continuous glucose monitors es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.title Effect of Ethanol Consumption on the Accuracy of a Glucose Oxidase-Based Subcutaneous Glucose Sensor in Subjects with Type 1 Diabetes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/s22093101 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107722RB-C21/ES/SOLUCIONES A MEDIDA DEL PACIENTE PARA EL CONTROL DE GLUCOSA EN SANGRE EN DIABETES TIPO 1/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//DPI2016-78831-C2-1-R//SOLUCIONES PARA LA MEJORA DE LA EFICIENCIA Y SEGURIDAD DEL PÁNCREAS ARTIFICIAL MEDIANTE ARQUITECTURAS DE CONTROL MULTIVARIABLE TOLERANTES A FALLOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Automática e Informática Industrial - Institut Universitari d'Automàtica i Informàtica Industrial es_ES
dc.description.bibliographicCitation Moscardó, V.; Garcia, A.; Bondía Company, J.; Diaz, J.; Ramos-Prol, A.; Rossetti, P. (2022). Effect of Ethanol Consumption on the Accuracy of a Glucose Oxidase-Based Subcutaneous Glucose Sensor in Subjects with Type 1 Diabetes. Sensors. 22(9):1-9. https://doi.org/10.3390/s22093101 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/s22093101 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 9 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 22 es_ES
dc.description.issue 9 es_ES
dc.identifier.eissn 1424-8220 es_ES
dc.identifier.pmid 35590791 es_ES
dc.identifier.pmcid PMC9104985 es_ES
dc.relation.pasarela S\490286 es_ES
dc.contributor.funder AGENCIA ESTATAL DE INVESTIGACION es_ES
dc.contributor.funder European Regional Development Fund es_ES
upv.costeAPC 2356,72 es_ES


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