Chesney E, Goodwin GM, Fazel S. Risks of all-cause and suicide mortality in mental disorders: A meta-review. World Psychiatry. 2014;13:153–69.
Hoehe MR, Morris-Rosendahl DJ. The role of genetics and genomics in clinical psychiatry. Dialogues Clin Neurosci. 2018;20:169–77.
Uher R. Gene-environment interactions in severe mental illness. Front Psychiatry. 2014;15:48. 5
[+]
Chesney E, Goodwin GM, Fazel S. Risks of all-cause and suicide mortality in mental disorders: A meta-review. World Psychiatry. 2014;13:153–69.
Hoehe MR, Morris-Rosendahl DJ. The role of genetics and genomics in clinical psychiatry. Dialogues Clin Neurosci. 2018;20:169–77.
Uher R. Gene-environment interactions in severe mental illness. Front Psychiatry. 2014;15:48. 5
Edvardsen J, Torgersen S, Røysamb E, Lygren S, Skre I, Onstad S, et al. Heritability of bipolar spectrum disorders. Unity or heterogeneity? J Affect Disord 2008;106:229–40.
Rojo-Moreno L, Iranzo-Tatay C, Gimeno-Clemente N, Barberá-Fons MA, Rojo-Bofill LM, Livianos-Aldana L, et al. Genetic and environmental influences on psychological traits and eating attitudes in a sample of Spanish schoolchildren. Rev Psiquiatr Salud Ment. 2017;10:134–42.
Geschwind DH, Flint J. Genetics and genomics of psychiatric disease. Science 2015;25:1489–94. 349
Millan MJ, Ricca V, Oliver D, Kingdon J, Valmaggia L, McGuire P, et al. Deconstructing vulnerability for psychosis: Meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur Psychiatry. 2017;40:65–75.
Steiger H, Booij L. Eating disorders, heredity and environmental activation: getting epigenetic concepts into practice. J Clin Med. 2020;9:1332.
Föcking M, Doyle B, Munawar N, Dillon ET, Cotter D, Cagney G, et al. Epigenetic factors in schizophrenia: mechanisms and experimental approaches. Mol Neuropsychiatry. 2019;5:6–12.
Campbell IC, Mill J, Uher R, Schmidt U. Eating disorders, gene-environment interactions and epigenetics. Neurosci Biobehav Rev. 2011;35:784–93.
Castillo-Fernandez JE, Spector TD, Bell JT. Epigenetics of discordant monozygotic twins: Implications for disease. Genome Med. 2014;31:60. 6
Lorente-Pozo S, Parra-Llorca A, Núñez-Ramiro A, Cernada M, Hervás D, Boronat N, et al. The oxygen load supplied during delivery room stabilization of preterm infants modifies the DNA methylation profile. J Pediatr. 2018;202:70–76.
Hannon E, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, et al. Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genet. 2018;9:14.
Kesselmeier M, Pütter C, Volckmar AL, Baurecht H, Grallert H, Illig T, et al. High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. World J Biol Psychiatry. 2018;19:187–99.
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet. 2011;20:4786–96.
Heyn H, Carmona Javier F, Gomez A, Ferreira HJ, Bell JT, Sayols S, et al. DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. Carcinogenesis 2013;34:102–8.
Zhou W, Laird PW, Shen H. Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes. Nucleic Acids Res. 2017;45:e22.
Frieling H, Bleich S, Otten J, Römer KD, Kornhuber J, De Zwaan M, et al. Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity. Neuropsychopharmacology 2008;33:2605–9.
Frieling H, Rómer KD, Scholz S, Mittelbach F, Wilhelm J, De Zwaan M, et al. Epigenetic dysregulation of dopaminergic genes in eating disorders. Int J Eat Disord. 2010;43:577–83.
Groleau P, Joober R, Israel M, Zeramdini N, DeGuzman R, Steiger H, et al. Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: Associations with borderline personality disorder and exposure to childhood abuse. J Psychiatr Res. 2014;48:121–7.
Steiger H, Labonté B, Groleau P, Turecki G, Israel M. Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse. Int J Eat Disord. 2013;46:246–55.
Kim YR, Kim JH, Kim MJ, Treasure J. Differential methylation of the oxytocin receptor gene in patients with anorexia nervosa: a pilot study. PLoS ONE. 2014;11:9.
Tremolizzo L, Conti E, Bomba M, Uccellini O, Rossi MS, Marfone M, et al. Decreased whole-blood global DNA methylation is related to serum hormones in anorexia nervosa adolescents. World J Biol Psychiatry. 2014;15:327–33.
Saffrey R, Novakovic B, Wade TD. Assessing global and gene specific DNA methylation in anorexia nervosa: a pilot study. Int J Eat Disord. 2014;47:206–10.
Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, et al. Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res. 2013;47:280–2.
Hübel C, Marzi SJ, Breen G, Bulik CM. Epigenetics in eating disorders: a systematic review. Mol Psychiatry. 2019;24:901–15.
Himmerich H, Bentley J, Kan C, Treasure J. Genetic risk factors for eating disorders: an update and insights into pathophysiology. Ther Adv Psychopharmacol. 2019;12:9.
Steiger H, Booij L, Kahan E, McGregor K, Thaler L, Fletcher E, et al. Longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: Results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women. J Psychiatry Neurosci. 2019;44:205–13.
Schorr M, Miller KK. The endocrine manifestations of anorexia nervosa: mechanisms and management. Nat Rev Endocrinol 2017;13:147–86.
Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JRI, Gaspar HA, et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet. 2019;51:1207–14.
Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009;41:1110–5.
Fox CS, Heard-Costa N, Cupples LA, Dupuis J, Vasan RS, Atwood LD. Genome-wide association to body mass index and waist circumference: The Framingham Heart Study 100K project. BMC Med Genet. 2007;8:1–7.
Wood AR, Jonsson A, Jackson AU, Wang N, Van Leewen N, Palmer ND, et al. A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants. Diabetes 2017;66:2296–309.
Wang RN, Green J, Wang Z, Deng Y, Qiao M, Peabody M, et al. Bone Morphogenetic Protein (BMP) signaling in development and human diseases. Genes Dis. 2014;1:87–105.
Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, et al. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes 2009;58:2119–28.
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, et al. The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PLoS Genet. 2015;12:e1006166.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, et al. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019;51:804–14.
Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V, et al. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry. 2017;174:850–8.
Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet. 2009;41:35–46.
Li J, Lange LA, Sabourin J, Duan Q, Valdar W, Willis MS, et al. Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study. J Hum Genet. 2015;60:755–61.
Yan C, Wang P, Demayo J, Demayo FJ, Elvin JA, Carino C, et al. Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol. 2001;15:854–66.
Sugiura K, Su Y-Q, Eppig JJ. Does bone morphogenetic protein 6 (BMP6) affect female fertility in the mouse?. Biol Reprod. 2010;83:997–1004.
Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM. BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013;123:2539–50.
Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW, et al. Genetic variants associated with disordered eating. Int J Eat Disord. 2013;46:594–608.
Marucci S, Ragione LD, De Iaco G, Mococci T, Vicini M, Guastamacchia E, et al. Anorexia nervosa and comorbid psychopathology. Endocr Metab Immune Disord Drug Targets. 2018;18:316–24.
Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil É, et al. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Blood 2014;124:2362–9.
Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51:793–803.
Verweij KJH, Vinkhuyzen AAE, Benyamin B, Lynskey MT, Quaye L, Agrawal A, et al. The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation. Addict Biol. 2013;18:846–50.
Viveros MP, Bermúdez-Silva FJ, Lopez-Rodriguez AB, Wagner EJ. The endocannabinoid system as pharmacological target derived from its CNS role in energy homeostasis and reward. Applications in eating disorders and addiction. Pharmaceuticals 2011;4:1101–36.
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