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Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins

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Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins

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dc.contributor.author Iranzo-Tatay, C. es_ES
dc.contributor.author Hervás-Marín, David es_ES
dc.contributor.author Rojo-Bofill, L.M. es_ES
dc.contributor.author Garcia, D. es_ES
dc.contributor.author Vaz-Leal, F.J. es_ES
dc.contributor.author Calabria, I. es_ES
dc.contributor.author Beato-Fernandez, L. es_ES
dc.contributor.author Oltra, S. es_ES
dc.contributor.author Sandoval, J. es_ES
dc.contributor.author Rojo-Moreno, L. es_ES
dc.date.accessioned 2023-11-06T19:01:53Z
dc.date.available 2023-11-06T19:01:53Z
dc.date.issued 2022-01-10 es_ES
dc.identifier.uri http://hdl.handle.net/10251/199362
dc.description.abstract [EN] Up until now, no study has looked specifically at epigenomic landscapes throughout twin samples, discordant for Anorexia nervosa (AN). Our goal was to find evidence to confirm the hypothesis that epigenetic variations play a key role in the aetiology of AN. In this study, we quantified genome-wide patterns of DNA methylation using the Infinium Human DNA Methylation EPIC BeadChip array ("850 K") in DNA samples isolated from whole blood collected from a group of 7 monozygotic twin pairs discordant for AN. Results were then validated performing a genome-wide DNA methylation profiling using DNA extracted from whole blood of a group of non-family-related AN patients and a group of healthy controls. Our first analysis using the twin sample revealed 9 CpGs associated to a gene. The validation analysis showed two statistically significant CpGs with the rank regression method related to two genes associated to metabolic traits, PPP2R2C and CHST1. When doing beta regression, 6 of them showed statistically significant differences, including 3 CpGs associated to genes JAM3, UBAP2L and SYNJ2. Finally, the overall pattern of results shows genetic links to phenotypes which the literature has constantly related to AN, including metabolic and psychological traits. The genes PPP2R2C and CHST1 have both been linked to the metabolic traits type 2 diabetes through GWAS studies. The genes UBAP2L and SYNJ2 have been related to other psychiatric comorbidity. es_ES
dc.description.sponsorship This work was supported by a FIS grant (PI16/01279) from the FEDER, FSE and Carlos III Health Institute (ISCIII). es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Translational Psychiatry es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.title Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41398-021-01776-y es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI16%2F01279/ES/Caracterización epigenómica de la anorexia nerviosa. Modelo de gemelas monocigotas discordantes y validación en población general/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Politécnica Superior de Alcoy - Escola Politècnica Superior d'Alcoi es_ES
dc.description.bibliographicCitation Iranzo-Tatay, C.; Hervás-Marín, D.; Rojo-Bofill, L.; Garcia, D.; Vaz-Leal, F.; Calabria, I.; Beato-Fernandez, L.... (2022). Genome-wide DNA methylation profiling in anorexia nervosa discordant identical twins. Translational Psychiatry. 12(1):1-8. https://doi.org/10.1038/s41398-021-01776-y es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41398-021-01776-y es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 2158-3188 es_ES
dc.identifier.pmid 35013117 es_ES
dc.identifier.pmcid PMC8748827 es_ES
dc.relation.pasarela S\456517 es_ES
dc.contributor.funder European Social Fund es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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