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Effect of providing citrus pulp-integrated diet on fecal microbiota and serum and fecal metabolome shifts in crossbred pigs

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Effect of providing citrus pulp-integrated diet on fecal microbiota and serum and fecal metabolome shifts in crossbred pigs

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dc.contributor.author Belloumi, Dhekra es_ES
dc.contributor.author Calvet, S. es_ES
dc.contributor.author Roca, Marta Isabel es_ES
dc.contributor.author Ferrer, Pablo es_ES
dc.contributor.author Jiménez Belenguer, Ana Isabel es_ES
dc.contributor.author Cambra López, María es_ES
dc.contributor.author García-Rebollar, Paloma es_ES
dc.contributor.author Climent, Eric es_ES
dc.contributor.author Martinez-Blanch, Juan es_ES
dc.contributor.author Tortajada, Marta es_ES
dc.contributor.author Chenoll, Empar es_ES
dc.contributor.author Bermejo, Almudena es_ES
dc.contributor.author Cerisuelo, Alba es_ES
dc.date.accessioned 2023-12-26T19:02:37Z
dc.date.available 2023-12-26T19:02:37Z
dc.date.issued 2023-10-16 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/201122
dc.description.abstract [EN] The study aimed to assess the impact of dehydrated citrus pulp (DCP) on growth performance, fecal characteristics, fecal bacterial composition (based on 16S rRNA analysis), and fecal and serum metabolomic profiles in crossbred pigs. 80 finishing pigs Duroc x (Landrace x Large White) were fed either a control diet (C) or a diet with 240 g/kg DCP (T) for six weeks. Including DCP in diets tended to decrease feed intake, increased (p < 0.05) the concentrations of acetic and heptanoic acids and decreased (p < 0.05) fecal butyric and branched-chain fatty acid concentrations in feces. Animals fed DCP exhibited a lower abundance of the genera Clostridium and Romboutsia, while Lachnospira significantly increased. Orthogonal partial least squares discriminant analysis plotted a clear separation of fecal and serum metabolites between groups. The main discriminant fecal metabolites were associated with bacterial protein fermentation and were downregulated in T-fed pigs. In serum, DCP supplementation upregulated metabolites related to protein and fatty acids metabolism. In conclusion, the addition of DCP as an environmentally friendly source of nutrients in pig diets, resulted in modifications of fecal bacterial composition, fermentation patterns, and overall pig metabolism, suggesting improvements in protein metabolism and gut health. es_ES
dc.description.sponsorship This project was funded by the Spanish Ministry of Science and Innovation (AGL2014-56653 and RTI-2018-095246-B-C22). Dhekra Belloumi is a recipient of the Santiago Grisolia PhD scholarship (GRISOLIAP/2020/023). es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Dehydrated citrus pulp es_ES
dc.subject Microbiota es_ES
dc.subject Metabolome es_ES
dc.subject Crossbred pigs es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Effect of providing citrus pulp-integrated diet on fecal microbiota and serum and fecal metabolome shifts in crossbred pigs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-023-44741-z es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2014-56653-C3-2-R/ES/EFECTO DE LA INCLUSION DE SUBPRODUCTOS EN LAS EMISIONES DE GASES DE LOS PURINES. EVALUACION GLOBAL DE LOS IMPACTOS AMBIENTALES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GRISOLIAP%2F2020%2F023/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//RTI-2018-095246-B-C22/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Belloumi, D.; Calvet, S.; Roca, MI.; Ferrer, P.; Jiménez Belenguer, AI.; Cambra López, M.; García-Rebollar, P.... (2023). Effect of providing citrus pulp-integrated diet on fecal microbiota and serum and fecal metabolome shifts in crossbred pigs. Scientific Reports. 13(1):1-19. https://doi.org/10.1038/s41598-023-44741-z es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-023-44741-z es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 19 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 37845279 es_ES
dc.identifier.pmcid PMC10579234 es_ES
dc.relation.pasarela S\501533 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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