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dc.contributor.author | Marcos-Garces, Victor![]() |
es_ES |
dc.contributor.author | Merenciano-Gonzalez, Héctor![]() |
es_ES |
dc.contributor.author | Martinez Mas, Maria Luz![]() |
es_ES |
dc.contributor.author | Palau, Patricia![]() |
es_ES |
dc.contributor.author | Climent Alberola, Josefa Ines![]() |
es_ES |
dc.contributor.author | Pérez, Nerea![]() |
es_ES |
dc.contributor.author | Lopez-Bueno, Laura![]() |
es_ES |
dc.contributor.author | Esteban Argente, Maria Concepcion![]() |
es_ES |
dc.contributor.author | Valls Reig, Maria![]() |
es_ES |
dc.contributor.author | Muñoz Alcover, Raquel![]() |
es_ES |
dc.contributor.author | Pradillas Contreras, Inmaculada![]() |
es_ES |
dc.contributor.author | Arizon Benito, Ana![]() |
es_ES |
dc.contributor.author | Paya Rubio, Alfonso![]() |
es_ES |
dc.contributor.author | Rios-Navarro, César![]() |
es_ES |
dc.contributor.author | Gavara-Doñate, Josep![]() |
es_ES |
dc.date.accessioned | 2024-06-17T18:08:18Z | |
dc.date.available | 2024-06-17T18:08:18Z | |
dc.date.issued | 2024-01 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/205212 | |
dc.description.abstract | [EN] We hypothesized that a short-course high-intensity statin treatment during admission for myocardial infarction (MI) could rapidly reduce LDL-C and thus impact the choice of lipid-lowering therapy (LLT) at discharge. Our cohort comprised 133 MI patients (62.71 +/- 11.3 years, 82% male) treated with atorvastatin 80 mg o.d. during admission. Basal LDL-C levels before admission were analyzed. We compared lipid profile variables before and during admission, and LLT at discharge was registered. Achieved theoretical LDL-C levels were estimated using LDL-C during admission and basal LDL-C as references and compared to LDL-C on first blood sample 4-6 weeks after discharge. A significant reduction in cholesterol from basal levels was noted during admission, including total cholesterol, triglycerides, HDL-C, non-HDL-C, and LDL-C (-39.23 +/- 34.89 mg/dL, p < 0.001). LDL-C levels were reduced by 30% in days 1-2 and 40-45% in subsequent days (R-2 0.766, p < 0.001). Using LDL-C during admission as a reference, most patients (88.7%) would theoretically achieve an LDL-C < 55 mg/dL with discharge LLT. However, if basal LDL-C levels were considered as a reference, only a small proportion of patients (30.1%) would achieve this lipid target, aligned with the proportion of patients with LDL-C < 55 mg/dL 4-6 weeks after discharge (36.8%). We conclude that statin treatment during admission for MI can induce a significant reduction in LDL-C and LLT at discharge is usually prescribed using LDL-C during admission as the reference, which leads to insufficient LDL-C reduction after discharge. Basal LDL-C before admission should be considered as the reference value for tailored LLT prescription. | es_ES |
dc.description.sponsorship | This work was supported by grants from Instituto de Salud Carlos III , Fondos Europeos de Desarrollo Regional FEDER , and Fondo Social Europeo Plus (FSE + ) (grant numbers PI20/00637, PI23/01150, and CIBERCV16/11/00486, and CM21/00175 and JR23/00032 to V.M.-G.), Conselleria de Educación Generalitat Valenciana (PROMETEO/2021/008) and GE 2023 grant by the Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital of the Generalitat Valenciana (CIGE/2022/26). J.G. acknowledges financial support from the Agencia Estatal de Investigación (grant FJC2020-043981-I). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | Journal of Clinical Medicine | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | High-intensity statin | es_ES |
dc.subject | Lipid-lowering therapy | es_ES |
dc.subject | Low-density lipoprotein cholesterol | es_ES |
dc.subject | Acute myocardial infarction | es_ES |
dc.subject | Cardiac rehabilitation | es_ES |
dc.title | Short-Course High-Intensity Statin Treatment during Admission for Myocardial Infarction and LDL-Cholesterol Reduction-Impact on Tailored Lipid-Lowering Therapy at Discharge | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/jcm13010127 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00637/ES/RESOLUCION DE LA OBSTRUCCION MICROVASCULAR TRAS UN INFARTO DE MIOCARDIO: EVALUACION DE LAS CONSECUENCIAS ESTRUCTURALES Y CLINICAS Y BUSQUEDA DE NUEVAS OPCIONES TERAPEUTICAS./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00486/ES/ENFERMEDADES CARDIOVASCULARES/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//CIGE%2F2022%2F26/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2021%2F008/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PI23%2F01150/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//CM21%2F00175/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//JR23%2F00032/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI//FJC2020-043981-I/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Marcos-Garces, V.; Merenciano-Gonzalez, H.; Martinez Mas, ML.; Palau, P.; Climent Alberola, JI.; Pérez, N.; Lopez-Bueno, L.... (2024). Short-Course High-Intensity Statin Treatment during Admission for Myocardial Infarction and LDL-Cholesterol Reduction-Impact on Tailored Lipid-Lowering Therapy at Discharge. Journal of Clinical Medicine. 13(1). https://doi.org/10.3390/jcm13010127 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/jcm13010127 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 13 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.eissn | 2077-0383 | es_ES |
dc.identifier.pmid | 38202134 | es_ES |
dc.identifier.pmcid | PMC10780070 | es_ES |
dc.relation.pasarela | S\513784 | es_ES |
dc.contributor.funder | European Social Fund | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |