Marcos-Garces, V.; Merenciano-Gonzalez, H.; Martinez Mas, ML.; Palau, P.; Climent Alberola, JI.; Pérez, N.; Lopez-Bueno, L.... (2024). Short-Course High-Intensity Statin Treatment during Admission for Myocardial Infarction and LDL-Cholesterol Reduction-Impact on Tailored Lipid-Lowering Therapy at Discharge. Journal of Clinical Medicine. 13(1). https://doi.org/10.3390/jcm13010127
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/205212
Título:
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Short-Course High-Intensity Statin Treatment during Admission for Myocardial Infarction and LDL-Cholesterol Reduction-Impact on Tailored Lipid-Lowering Therapy at Discharge
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Autor:
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Marcos-Garces, Victor
Merenciano-Gonzalez, Héctor
Martinez Mas, Maria Luz
Palau, Patricia
Climent Alberola, Josefa Ines
Pérez, Nerea
Lopez-Bueno, Laura
Esteban Argente, Maria Concepcion
Valls Reig, Maria
Muñoz Alcover, Raquel
Pradillas Contreras, Inmaculada
Arizon Benito, Ana
Paya Rubio, Alfonso
Rios-Navarro, César
Gavara-Doñate, Josep
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Fecha difusión:
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Resumen:
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[EN] We hypothesized that a short-course high-intensity statin treatment during admission for myocardial infarction (MI) could rapidly reduce LDL-C and thus impact the choice of lipid-lowering therapy (LLT) at discharge. ...[+]
[EN] We hypothesized that a short-course high-intensity statin treatment during admission for myocardial infarction (MI) could rapidly reduce LDL-C and thus impact the choice of lipid-lowering therapy (LLT) at discharge. Our cohort comprised 133 MI patients (62.71 +/- 11.3 years, 82% male) treated with atorvastatin 80 mg o.d. during admission. Basal LDL-C levels before admission were analyzed. We compared lipid profile variables before and during admission, and LLT at discharge was registered. Achieved theoretical LDL-C levels were estimated using LDL-C during admission and basal LDL-C as references and compared to LDL-C on first blood sample 4-6 weeks after discharge. A significant reduction in cholesterol from basal levels was noted during admission, including total cholesterol, triglycerides, HDL-C, non-HDL-C, and LDL-C (-39.23 +/- 34.89 mg/dL, p < 0.001). LDL-C levels were reduced by 30% in days 1-2 and 40-45% in subsequent days (R-2 0.766, p < 0.001). Using LDL-C during admission as a reference, most patients (88.7%) would theoretically achieve an LDL-C < 55 mg/dL with discharge LLT. However, if basal LDL-C levels were considered as a reference, only a small proportion of patients (30.1%) would achieve this lipid target, aligned with the proportion of patients with LDL-C < 55 mg/dL 4-6 weeks after discharge (36.8%). We conclude that statin treatment during admission for MI can induce a significant reduction in LDL-C and LLT at discharge is usually prescribed using LDL-C during admission as the reference, which leads to insufficient LDL-C reduction after discharge. Basal LDL-C before admission should be considered as the reference value for tailored LLT prescription.
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Palabras clave:
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High-intensity statin
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Lipid-lowering therapy
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Low-density lipoprotein cholesterol
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Acute
myocardial infarction
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Cardiac rehabilitation
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Derechos de uso:
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Reconocimiento (by)
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Fuente:
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Journal of Clinical Medicine. (eissn:
2077-0383
)
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DOI:
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10.3390/jcm13010127
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Editorial:
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MDPI AG
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Versión del editor:
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https://doi.org/10.3390/jcm13010127
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Código del Proyecto:
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info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00637/ES/RESOLUCION DE LA OBSTRUCCION MICROVASCULAR TRAS UN INFARTO DE MIOCARDIO: EVALUACION DE LAS CONSECUENCIAS ESTRUCTURALES Y CLINICAS Y BUSQUEDA DE NUEVAS OPCIONES TERAPEUTICAS./
...[+]
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00637/ES/RESOLUCION DE LA OBSTRUCCION MICROVASCULAR TRAS UN INFARTO DE MIOCARDIO: EVALUACION DE LAS CONSECUENCIAS ESTRUCTURALES Y CLINICAS Y BUSQUEDA DE NUEVAS OPCIONES TERAPEUTICAS./
info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00486/ES/ENFERMEDADES CARDIOVASCULARES/
info:eu-repo/grantAgreement/GVA//CIGE%2F2022%2F26/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2021%2F008/
info:eu-repo/grantAgreement/ISCIII//PI23%2F01150/
info:eu-repo/grantAgreement/ISCIII//CM21%2F00175/
info:eu-repo/grantAgreement/ISCIII//JR23%2F00032/
info:eu-repo/grantAgreement/AEI//FJC2020-043981-I/
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Agradecimientos:
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This work was supported by grants from Instituto de Salud Carlos III , Fondos Europeos de Desarrollo Regional FEDER , and Fondo Social Europeo Plus (FSE + ) (grant numbers
PI20/00637, PI23/01150, and CIBERCV16/11/00486, ...[+]
This work was supported by grants from Instituto de Salud Carlos III , Fondos Europeos de Desarrollo Regional FEDER , and Fondo Social Europeo Plus (FSE + ) (grant numbers
PI20/00637, PI23/01150, and CIBERCV16/11/00486, and CM21/00175 and JR23/00032 to V.M.-G.),
Conselleria de Educación Generalitat Valenciana (PROMETEO/2021/008) and GE 2023 grant by the
Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital of the Generalitat Valenciana
(CIGE/2022/26). J.G. acknowledges financial support from the Agencia Estatal de Investigación
(grant FJC2020-043981-I).
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Tipo:
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Artículo
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