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Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants

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Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants

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dc.contributor.author Hernández-Olivas, Éver es_ES
dc.contributor.author Asensio-Grau, Andrea es_ES
dc.contributor.author Calvo-Lerma, Joaquim es_ES
dc.contributor.author Heredia Gutiérrez, Ana Belén es_ES
dc.contributor.author Andrés Grau, Ana María es_ES
dc.date.accessioned 2024-06-19T18:07:32Z
dc.date.available 2024-06-19T18:07:32Z
dc.date.issued 2023-09-29 es_ES
dc.identifier.uri http://hdl.handle.net/10251/205268
dc.description.abstract [EN] There is little information about the impact of refrigeration and freezing-thawing on breast milk digestibility under gastrointestinal conditions of healthy infants or those requiring pancreatic enzyme replacement therapy (PERT) such as infants with cystic fibrosis (CF). This study assessed the impact of refrigeration and freezing-thawing on fat and protein digestibility and liposoluble vitamin bioaccessibility of breast milk. In vitro digestion models mimicking both healthy infant and CF infant conditions were applied. Freezing-thawing significantly increased the fat globule particle size. For CF digestion, this change had a more negative impact when using a freezing-thawing process than when using refrigeration of breast milk, reducing lipolysis (up to 18%), proteolysis (up to 28%), and vitamin A and E bioaccessibility. Under healthy conditions, no significant effects were detected. An adequate pancreatic enzyme replacement therapy (PERT) dose (25 LU/mL of BM) would enable the same level of lipolysis (55%) as in the healthy scenario. In conclusion, breast milk is the only source of energy and nutrients for breast-fed infants, so to prevent the loss of nutrient absorption, those with CF should not be fed with frozen-thawed breast milk. es_ES
dc.description.sponsorship This research was funded by Generalitat Valenciana, Conselleria de Innovacio, Universitats, Ciència i Societat Digital (Enzimapp Project, ref. AICO/2021/015) and by the Spanish Ministry of Health, Health Research Institute Carlos III (mHealthFQ Project, ref. DTS21/00162) The authors also acknowledge Universitat Politècnica de València for the post-doctoral research grant awarded to Andrea Asensio-Grau. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof LWT - Food Science & Technology (Online) es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Breast milk es_ES
dc.subject Lipolysis es_ES
dc.subject Proteolysis es_ES
dc.subject Cystic fibrosis es_ES
dc.subject Pancreatic insufficiency es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.lwt.2023.115348 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/DTS21%2F00162/ES/SISTEMA DE AUTO-GESTION DEL TRATAMIENTO ENZIMATICO EN FIBROSIS QUISTICA CON UNA APP MOVIL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//AICO%2F2021%2F015/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Hernández-Olivas, É.; Asensio-Grau, A.; Calvo-Lerma, J.; Heredia Gutiérrez, AB.; Andrés Grau, AM. (2023). Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants. LWT - Food Science & Technology (Online). 187. https://doi.org/10.1016/j.lwt.2023.115348 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.lwt.2023.115348 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 187 es_ES
dc.identifier.eissn 1096-1127 es_ES
dc.relation.pasarela S\499984 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder FUNDACION PARA LA INVESTIGACION DEL HOSPITAL LA FE VALENCIA es_ES


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