Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on (18)F Radionuclide Emission

Abstract

[EN] Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to con¿rm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently proposed as a promising biomaterial. In this study, we labeled nanodiamonds with 18F to study their in vivo biodistribution by positron emission tomography. Moreover, the impact on the biodistribution of their kinetic particle size and of the surfactant agents has been evaluated. Radiolabeled diamond nanoparticles accumulated mainly in the lung, spleen, and liver and were excreted into the urinary tract. The addition of surfactant agents did not lead to signi¿cant changes in this pattern, with the exception of a slight reduction in the urinary excretion rate. On the other hand, after ¿ltration of the radiolabeled diamond nanoparticles to remove those with a larger kinetic size, the uptake in the lung and spleen was completely inhibited and signi¿cantly reduced in the liver